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HAMAP rule MF_01182

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General rule information [?]

Accession MF_01182
Dates 24-NOV-2006 (Created)
26-JAN-2023 (Last updated, Version 32)
Name Cytochrom_C552
Bacteria; Bacteroidota
Bacteria; Pseudomonadota
Template P0ABK9 (NRFA_ECOLI)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Cytochrome c-552;
AltName: Full=Ammonia-forming cytochrome c nitrite reductase;
Short=Cytochrome c nitrite reductase;
Flags: Precursor;
Gene name

Comments [?]

Function Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process.
Catalytic activity RHEA:13089: 6 Fe(III)-[cytochrome c] + 2 H2O + NH4(+) = 6 Fe(II)-[cytochrome c] + 8 H(+) + nitrite
case <FTGroup:2>
Cofactor Ca(2+)
Note: Binds 1 Ca(2+) ion per monomer.
end case
case <FTGroup:3> or <FTGroup:4> or <FTGroup:5> or <FTGroup:6> or <FTGroup:7>
Cofactor heme c
Note: Binds 5 heme c groups covalently per monomer.
end case
Pathway Nitrogen metabolism; nitrate reduction (assimilation).
Subcellular location Periplasm.
Similarity Belongs to the cytochrome c-552 family.

Keywords [?]

case <FTGroup:2>
end case
case <FTGroup:3> or <FTGroup:4> or <FTGroup:5> or <FTGroup:6> or <FTGroup:7>
end case
case <FTGroup:1>
end case

Gene Ontology [?]

case <FTGroup:2>
GO:0005509; Molecular function: calcium ion binding.
end case
case <FTGroup:1>
GO:0005506; Molecular function: iron ion binding.
end case
GO:0042279; Molecular function: nitrite reductase (cytochrome, ammonia-forming) activity.
GO:0006807; Biological process: nitrogen compound metabolic process.
GO:0042597; Cellular component: periplasmic space.

Cross-references [?]

Pfam PF02335; Cytochrom_C552; 1;

Computed features [?]

General Signal; -; 1; trigger=yes;

Features [?]

Key     From     To       Description   Tag   Condition   FTGroup
BINDING     94     94       /ligand="heme c" /ligand_id="ChEBI:CHEBI:61717" /ligand_label="3" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="axial binding residue     H   1
BINDING     126     126       /ligand="heme c" /ligand_id="ChEBI:CHEBI:61717" /ligand_label="1" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="axial binding residue     K   1
BINDING     164     164       /ligand="heme c" /ligand_id="ChEBI:CHEBI:61717" /ligand_label="2" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="axial binding residue     H   1
BINDING     213     213       /ligand="heme c" /ligand_id="ChEBI:CHEBI:61717" /ligand_label="3" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="axial binding residue     H   1
BINDING     215     215       /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108     E   2
BINDING     216     216       /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108     Y   2
BINDING     261     261       /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108     K   2
BINDING     263     263       /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108     Q   2
BINDING     275     275       /ligand="heme c" /ligand_id="ChEBI:CHEBI:61717" /ligand_label="5" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="axial binding residue     H   1
BINDING     286     286       /ligand="heme c" /ligand_id="ChEBI:CHEBI:61717" /ligand_label="4" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="axial binding residue     H   1
BINDING     301     301       /ligand="heme c" /ligand_id="ChEBI:CHEBI:61717" /ligand_label="2" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="axial binding residue     H   1
BINDING     318     318       /ligand="heme c" /ligand_id="ChEBI:CHEBI:61717" /ligand_label="5" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="axial binding residue     H   1
BINDING     393     393       /ligand="heme c" /ligand_id="ChEBI:CHEBI:61717" /ligand_label="4" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="axial binding residue     H   1
BINDING     122     122       /ligand="heme c" /ligand_id="ChEBI:CHEBI:61717" /ligand_label="1" /note="covalent     C   3
BINDING     125     125       /ligand="heme c" /ligand_id="ChEBI:CHEBI:61717" /ligand_label="1" /note="covalent     C   3
BINDING     160     160       /ligand="heme c" /ligand_id="ChEBI:CHEBI:61717" /ligand_label="2" /note="covalent     C   4
BINDING     163     163       /ligand="heme c" /ligand_id="ChEBI:CHEBI:61717" /ligand_label="2" /note="covalent     C   4
BINDING     209     209       /ligand="heme c" /ligand_id="ChEBI:CHEBI:61717" /ligand_label="3" /note="covalent     C   5
BINDING     212     212       /ligand="heme c" /ligand_id="ChEBI:CHEBI:61717" /ligand_label="3" /note="covalent     C   5
BINDING     216     216       /ligand="substrate     Y  
BINDING     264     264       /ligand="substrate     H  
BINDING     282     282       /ligand="heme c" /ligand_id="ChEBI:CHEBI:61717" /ligand_label="4" /note="covalent     C   6
BINDING     285     285       /ligand="heme c" /ligand_id="ChEBI:CHEBI:61717" /ligand_label="4" /note="covalent     C   6
BINDING     314     314       /ligand="heme c" /ligand_id="ChEBI:CHEBI:61717" /ligand_label="5" /note="covalent     C   7
BINDING     317     317       /ligand="heme c" /ligand_id="ChEBI:CHEBI:61717" /ligand_label="5" /note="covalent     C   7

Additional information [?]

Size range 463-538 amino acids
Related rules None
Fusion None