HAMAP rule MF_01184

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_01184
Accession	MF_01184
Dates	06-MAY-2008 (Created) 03-SEP-2024 (Last updated, Version 22)
Name	XPRTase
Scope(s)	Bacteria
Template(s)	P42085; [ Recover all ]
Triggered by	HAMAP; MF_01184 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	XPT
Protein name	RecName: Full=Xanthine phosphoribosyltransferase; Short=XPRTase; EC=2.4.2.22;
Gene name	Name=xpt;

Comments [?]

FUNCTION	Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
CATALYTIC ACTIVITY	Reaction=XMP + diphosphate = xanthine + 5-phospho-alpha-D-ribose 1- diphosphate; Xref=Rhea:RHEA:10800, ChEBI:CHEBI:17712, ChEBI:CHEBI:33019, ChEBI:CHEBI:57464, ChEBI:CHEBI:58017; EC=2.4.2.22;
PATHWAY	Purine metabolism; XMP biosynthesis via salvage pathway; XMP from xanthine: step 1/1.
SUBUNIT	Homodimer.
SUBCELLULAR LOCATION	Cytoplasm.
SIMILARITY	Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.

Keywords [?]

Gene Ontology [?]

GO:0000310; Molecular function:xanthine phosphoribosyltransferase activity

GO:0032265; Biological process:XMP salvage

GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Features [?]

From: XPT_BACSU (P42085)

Key

From

Description

Tag

Condition

FTGroup

BINDING

128

132

/ligand="5-phospho-alpha-D-ribose 1-diphosphate"
/ligand_id="ChEBI:CHEBI:58017"

BINDING

/ligand="xanthine"
/ligand_id="ChEBI:CHEBI:17712"

BINDING

/ligand="xanthine"
/ligand_id="ChEBI:CHEBI:17712"

[NT]

BINDING

156

/ligand="xanthine"
/ligand_id="ChEBI:CHEBI:17712"

Additional information [?]