HAMAP rule MF_01184
General rule information
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Accession | MF_01184 |
Dates | 6-MAY-2008 (Created)
1-JUN-2023 (Last updated, Version 19) |
Name | XPRTase |
Scope(s) |
Bacteria |
Template(s) | P42085 (XPT_BACSU); [ Recover all ] |
Triggered by |
HAMAP; MF_01184 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | XPT |
Protein name | RecName: Full=Xanthine phosphoribosyltransferase; Short=XPRTase; EC=2.4.2.22; |
Gene name | Name=xpt; |
Comments
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FUNCTION | Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. |
CATALYTIC ACTIVITY | Reaction=diphosphate + XMP = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine; Xref=Rhea:RHEA:10800, ChEBI:CHEBI:17712, ChEBI:CHEBI:33019, ChEBI:CHEBI:57464, ChEBI:CHEBI:58017; EC=2.4.2.22; |
PATHWAY | Purine metabolism; XMP biosynthesis via salvage pathway; XMP from xanthine: step 1/1. |
SUBUNIT | Homodimer. |
SUBCELLULAR LOCATION | Cytoplasm. |
SIMILARITY | Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily. |
Keywords
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Gene Ontology
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GO:0000310; Molecular function:xanthine phosphoribosyltransferase activity |
GO:0006166; Biological process:purine ribonucleoside salvage |
GO:0005737; Cellular component:cytoplasm |
Cross-references
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PROSITE | PS00103; PUR_PYR_PR_TRANSFER; 1; |
Pfam | PF00156; Pribosyltran; 1; |
NCBIfam | TIGR01744; XPRTase; 1; |
Features
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From: XPT_BACSU (P42085) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 128 | 132 | /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017" |
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BINDING | 20 | 20 | /ligand="xanthine" /ligand_id="ChEBI:CHEBI:17712" |
L | ||||||||
BINDING | 27 | 27 | /ligand="xanthine" /ligand_id="ChEBI:CHEBI:17712" |
[NT] | ||||||||
BINDING | 156 | 156 | /ligand="xanthine" /ligand_id="ChEBI:CHEBI:17712" |
K |
Additional information
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Size range | 188-211 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |