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HAMAP rule MF_01184

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General rule information [?]

Accession MF_01184
Dates 6-MAY-2008 (Created)
1-JUN-2023 (Last updated, Version 19)
Name XPRTase
Scope(s) Bacteria
Template(s) P42085 (XPT_BACSU); [ Recover all ]
Triggered by HAMAP; MF_01184 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier XPT
Protein name RecName: Full=Xanthine phosphoribosyltransferase;
Gene name Name=xpt;

Comments [?]

FUNCTIONConverts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
CATALYTIC ACTIVITY Reaction=diphosphate + XMP = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine; Xref=Rhea:RHEA:10800, ChEBI:CHEBI:17712, ChEBI:CHEBI:33019, ChEBI:CHEBI:57464, ChEBI:CHEBI:58017; EC=;
PATHWAYPurine metabolism; XMP biosynthesis via salvage pathway; XMP from xanthine: step 1/1.
SIMILARITYBelongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.

Keywords [?]

Gene Ontology [?]

GO:0000310; Molecular function:xanthine phosphoribosyltransferase activity
GO:0006166; Biological process:purine ribonucleoside salvage
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF00156; Pribosyltran; 1;
NCBIfam TIGR01744; XPRTase; 1;

Features [?]

From: XPT_BACSU (P42085)
Key From To Description Tag Condition FTGroup
BINDING 128 132 /ligand="5-phospho-alpha-D-ribose 1-diphosphate"
BINDING 20 20 /ligand="xanthine"
BINDING 27 27 /ligand="xanthine"
BINDING 156 156 /ligand="xanthine"

Additional information [?]

Size range 188-211 amino acids
Related rules None
Fusion Nter: None Cter: None

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