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Annotation rule MF_01184
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General rule information [?]

Accession MF_01184
Dates 6-MAY-2008 (Created)
19-NOV-2019 (Last updated, Version 15)
Name XPRTase
Scope
Bacteria
Template P42085 (XPT_BACSU)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
XPT
Protein name
RecName: Full=Xanthine phosphoribosyltransferase;
Short=XPRTase;
EC 2.4.2.22;
Gene name
xpt

Comments [?]

Function Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
Catalytic activity RHEA:10800: diphosphate + XMP = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine
EC 2.4.2.22
Pathway Purine metabolism; XMP biosynthesis via salvage pathway; XMP from xanthine: step 1/1.
Subunit Homodimer.
Subcellular location Cytoplasm.
Similarity Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.

Keywords [?]

Cytoplasm
Glycosyltransferase
Purine salvage
Transferase

Gene Ontology [?]

GO:0000310; Molecular function: xanthine phosphoribosyltransferase activity.
GO:0006166; Biological process: purine ribonucleoside salvage.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

PROSITE PS00103; PUR_PYR_PR_TRANSFER; 1;
Pfam PF00156; Pribosyltran; 1;
TIGRFAMs TIGR01744; XPRTase; 1;

Features [?]

From: XPT_BACSU (P42085)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     128     132       5-phospho-alpha-D-ribose 1-diphosphate binding        
BINDING     20     20       Xanthine; via amide nitrogen and carbonyl oxygen     L  
BINDING     27     27       Xanthine     [NT]  
BINDING     156     156       Xanthine     K  

Additional information [?]

Size range 188-211 amino acids
Related rules None
Fusion None


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