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Annotation rule MF_01192 |
Accession | MF_01192 |
Dates | 12-JUL-2007 (Created) 19-NOV-2019 (Last updated, Version 13) |
Name | Xni |
Scope | Bacteria; Gammaproteobacteria |
Template | P38506 (XNI_ECOLI) |
Triggered by |
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Protein name |
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Gene name |
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Function | Has flap endonuclease activity. During DNA replication, flap endonucleases cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. |
Cofactor | Mg(2+) Note: Binds 2 Mg(2+) per subunit. Only one magnesium ion has a direct interaction with the protein, the other interactions are indirect. |
K(+) Note: Binds 1 K(+) per subunit. The potassium ion strongly increases the affinity for DNA. |
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Similarity | Belongs to the Xni family. |
From: XNI_ECOLI (P38506) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
REGION | 184 | 189 | Interaction with DNA | |||||||||
METAL | 104 | 104 | Magnesium | D | ||||||||
METAL | 171 | 171 | Potassium; via carbonyl oxygen | [LIMF] | ||||||||
METAL (Optional) | 172 | 172 | Potassium; via carbonyl oxygen | A | ||||||||
METAL (Optional) | 180 | 180 | Potassium; via carbonyl oxygen | P | ||||||||
METAL | 182 | 182 | Potassium; via carbonyl oxygen | [VI] | ||||||||
METAL | 185 | 185 | Potassium; via carbonyl oxygen | [IV] |
Size range | 250-290 amino acids |
Related rules | None |
Fusion | None |