HAMAP rule MF_01195
General rule information
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| Accession | MF_01195 |
| Dates | 8-APR-2008 (Created) 26-JAN-2023 (Last updated, Version 16) |
| Name | NanM |
| Scope | Bacteria; Pseudomonadota |
| Template | P39371 (NANM_ECOLI) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses. |
| Catalytic activity | RHEA:25233: N-acetyl-alpha-neuraminate = N-acetyl-beta-neuraminate
EC 5.1.3.24 |
| Subunit | Homodimer. |
| Subcellular location | Periplasm. |
| Similarity | Belongs to the NanM family. |
Keywords
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Gene Ontology
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GO:0016857; Molecular function: racemase and epimerase activity, acting on carbohydrates and derivatives.
GO:0042597; Cellular component: periplasmic space.
GO:0042597; Cellular component: periplasmic space.
Cross-references
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Computed features
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| General | Signal; -; 1; trigger=yes; |
Features
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| From: NANM_ECOLI (P39371) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| REPEAT | 40 | 84 | Kelch 1 | |||||||||
| REPEAT | 86 | 137 | Kelch 2 | |||||||||
| REPEAT | 139 | 173 | Kelch 3 | |||||||||
| REPEAT | 174 | 219 | Kelch 4 | |||||||||
| REPEAT | 222 | 265 | Kelch 5 | |||||||||
| REPEAT | 287 | 336 | Kelch 6 | |||||||||
| REPEAT | 338 | 367 | Kelch 7 | |||||||||
| ACT_SITE | 228 | 228 | Proton acceptor | E | ||||||||
Additional information
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| Size range | 368-392 amino acids |
| Related rules | None |
| Fusion | None |