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HAMAP rule MF_01195

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General rule information [?]

Accession MF_01195
Dates 8-APR-2008 (Created)
1-JUN-2023 (Last updated, Version 17)
Name NanM
Bacteria; Pseudomonadota
Template P39371 (NANM_ECOLI)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=N-acetylneuraminate epimerase;
AltName: Full=N-acetylneuraminate mutarotase;
Short=Neu5Ac mutarotase;
AltName: Full=Sialic acid epimerase;
Flags: Precursor;
Gene name

Comments [?]

Function Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses.
Catalytic activity RHEA:25233: N-acetyl-alpha-neuraminate = N-acetyl-beta-neuraminate
Subunit Homodimer.
Subcellular location Periplasm.
Similarity Belongs to the NanM family.

Keywords [?]

Gene Ontology [?]

GO:0016857; Molecular function: racemase and epimerase activity, acting on carbohydrates and derivatives.
GO:0042597; Cellular component: periplasmic space.

Cross-references [?]

Pfam PF01344; Kelch_1; 1;
NCBIfam TIGR03547; Muta_rot_YjhT; 1;

Computed features [?]

General Signal; -; 1; trigger=yes;

Features [?]

From: NANM_ECOLI (P39371)
Key     From     To       Description   Tag   Condition   FTGroup
REPEAT     40     84       Kelch 1        
REPEAT     86     137       Kelch 2        
REPEAT     139     173       Kelch 3        
REPEAT     174     219       Kelch 4        
REPEAT     222     265       Kelch 5        
REPEAT     287     336       Kelch 6        
REPEAT     338     367       Kelch 7        
ACT_SITE     228     228       Proton acceptor     E  

Additional information [?]

Size range 368-392 amino acids
Related rules None
Fusion None