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HAMAP rule MF_01195

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General rule information [?]

Accession MF_01195
Dates 8-APR-2008 (Created)
1-JUN-2023 (Last updated, Version 17)
Name NanM
Scope(s) Bacteria
Pseudomonadota
Template(s) P39371 (NANM_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01195 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier NANM
Protein name RecName: Full=N-acetylneuraminate epimerase;
                 EC=5.1.3.24;
AltName: Full=N-acetylneuraminate mutarotase;
                 Short=Neu5Ac mutarotase;
AltName: Full=Sialic acid epimerase;
                 Flags: Precursor;
Gene name Name=nanM;

Comments [?]

FUNCTIONConverts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta- anomer, accelerating the equilibrium between the alpha- and beta- anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses.
CATALYTIC ACTIVITY Reaction=N-acetyl-alpha-neuraminate = N-acetyl-beta-neuraminate; Xref=Rhea:RHEA:25233, ChEBI:CHEBI:58705, ChEBI:CHEBI:58770; EC=5.1.3.24;
SUBUNITHomodimer.
SUBCELLULAR LOCATIONPeriplasm.
SIMILARITYBelongs to the NanM family.

Keywords [?]


Gene Ontology [?]

GO:0016857; Molecular function:racemase and epimerase activity, acting on carbohydrates and derivatives
GO:0042597; Cellular component:periplasmic space

Cross-references [?]

Pfam PF01344; Kelch_1; 1;
NCBIfam TIGR03547; Muta_rot_YjhT; 1;
General Signal; -; 1;

Features [?]

From: NANM_ECOLI (P39371)
Key From To Description Tag Condition FTGroup
REPEAT 40 84 /note="Kelch 1"
REPEAT 86 137 /note="Kelch 2"
REPEAT 139 173 /note="Kelch 3"
REPEAT 174 219 /note="Kelch 4"
REPEAT 222 265 /note="Kelch 5"
REPEAT 287 336 /note="Kelch 6"
REPEAT 338 367 /note="Kelch 7"
ACT_SITE 228 228 /note="Proton acceptor" E

Additional information [?]

Size range 368-392 amino acids
Related rules None
Fusion Nter: None Cter: None



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