HAMAP rule MF_01195
General rule information
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Accession | MF_01195 |
Dates | 8-APR-2008 (Created)
1-JUN-2023 (Last updated, Version 17) |
Name | NanM |
Scope(s) |
Bacteria Pseudomonadota |
Template(s) | P39371 (NANM_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_01195 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | NANM |
Protein name | RecName: Full=N-acetylneuraminate epimerase; EC=5.1.3.24; AltName: Full=N-acetylneuraminate mutarotase; Short=Neu5Ac mutarotase; AltName: Full=Sialic acid epimerase; Flags: Precursor; |
Gene name | Name=nanM; |
Comments
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FUNCTION | Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta- anomer, accelerating the equilibrium between the alpha- and beta- anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses. |
CATALYTIC ACTIVITY | Reaction=N-acetyl-alpha-neuraminate = N-acetyl-beta-neuraminate; Xref=Rhea:RHEA:25233, ChEBI:CHEBI:58705, ChEBI:CHEBI:58770; EC=5.1.3.24; |
SUBUNIT | Homodimer. |
SUBCELLULAR LOCATION | Periplasm. |
SIMILARITY | Belongs to the NanM family. |
Keywords
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Gene Ontology
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GO:0016857; Molecular function:racemase and epimerase activity, acting on carbohydrates and derivatives |
GO:0042597; Cellular component:periplasmic space |
Cross-references
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Features
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From: NANM_ECOLI (P39371) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
REPEAT | 40 | 84 | /note="Kelch 1" | |||||||||
REPEAT | 86 | 137 | /note="Kelch 2" | |||||||||
REPEAT | 139 | 173 | /note="Kelch 3" | |||||||||
REPEAT | 174 | 219 | /note="Kelch 4" | |||||||||
REPEAT | 222 | 265 | /note="Kelch 5" | |||||||||
REPEAT | 287 | 336 | /note="Kelch 6" | |||||||||
REPEAT | 338 | 367 | /note="Kelch 7" | |||||||||
ACT_SITE | 228 | 228 | /note="Proton acceptor" | E |
Additional information
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Size range | 368-392 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |