HAMAP rule MF_01195
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_01195 |
| Accession | MF_01195 |
| Dates | 8-APR-2008 (Created)
1-JUN-2023 (Last updated, Version 17) |
| Name | NanM |
| Scope(s) |
Bacteria Pseudomonadota |
| Template(s) | P39371 (NANM_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01195 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | NANM |
| Protein name | RecName: Full=N-acetylneuraminate epimerase; EC=5.1.3.24; AltName: Full=N-acetylneuraminate mutarotase; Short=Neu5Ac mutarotase; AltName: Full=Sialic acid epimerase; Flags: Precursor; |
| Gene name | Name=nanM; |
Comments
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| FUNCTION | Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta- anomer, accelerating the equilibrium between the alpha- and beta- anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses. |
| CATALYTIC ACTIVITY | Reaction=N-acetyl-alpha-neuraminate = N-acetyl-beta-neuraminate; Xref=Rhea:RHEA:25233, ChEBI:CHEBI:58705, ChEBI:CHEBI:58770; EC=5.1.3.24; |
| SUBUNIT | Homodimer. |
| SUBCELLULAR LOCATION | Periplasm. |
| SIMILARITY | Belongs to the NanM family. |
Keywords
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Gene Ontology
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| GO:0016857; Molecular function:racemase and epimerase activity, acting on carbohydrates and derivatives |
| GO:0042597; Cellular component:periplasmic space |
Cross-references
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Features
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| From: NANM_ECOLI (P39371) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| REPEAT | 40 | 84 | /note="Kelch 1" | |||||||||
| REPEAT | 86 | 137 | /note="Kelch 2" | |||||||||
| REPEAT | 139 | 173 | /note="Kelch 3" | |||||||||
| REPEAT | 174 | 219 | /note="Kelch 4" | |||||||||
| REPEAT | 222 | 265 | /note="Kelch 5" | |||||||||
| REPEAT | 287 | 336 | /note="Kelch 6" | |||||||||
| REPEAT | 338 | 367 | /note="Kelch 7" | |||||||||
| ACT_SITE | 228 | 228 | /note="Proton acceptor" | E | ||||||||
Additional information
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| Size range | 368-392 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |