HAMAP rule MF_01198

Accession	MF_01198
Dates	2-MAY-2008 (Created) 19-NOV-2019 (Last updated, Version 10)

Name	Anti_adapt_IraP

Scope

Bacteria; Enterobacteriaceae

Template

P0AAN9 (IRAP_ECOLI)

Triggered by

HAMAP; MF_01198 (Get profile general information and statistics)

Identifier

IRAP

Protein name

RecName: Full=Anti-adapter protein IraP;

Gene name

iraP

Function

Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS especially during phosphate and magnesium starvation, but also in stationary phase and during nitrogen starvation. Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway.

Function

Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS especially during phosphate starvation, but also in stationary phase and during nitrogen starvation. Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway.

Subunit	Interacts with RssB.
Subcellular location	Cytoplasm.
Similarity	Belongs to the IraP family.

Coiled coil
Cytoplasm
Stress response

GO:0009267; Biological process: cellular response to starvation.
GO:0005737; Cellular component: cytoplasm.

Pfam	PF10796; Anti-adapt_IraP; 1;

General

Coiled_coil; -; 1-unlimited; trigger=yes;

Size range	86-86 amino acids
Related rules	None
Fusion	None

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