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HAMAP rule MF_01203

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General rule information [?]

Accession MF_01203
Dates 8-FEB-2002 (Created)
28-NOV-2023 (Last updated, Version 35)
Name CLC_ClcB
Scope(s) Bacteria
Template(s) P76175 (CLCB_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01203 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

case <OC:Enterobacterales>
Identifier CLCB
Protein name RecName: Full=Voltage-gated ClC-type chloride channel ClcB;
Gene name Name=clcB;
Identifier CLCL
Protein name RecName: Full=Putative chloride channel protein ClcB-like;
end case

Comments [?]

case <OC:Enterobacterales>
FUNCTIONProbably acts as an electrical shunt for an outwardly- directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response.
end case
case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATIONCell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
SUBCELLULAR LOCATIONCell inner membrane; Multi-pass membrane protein.
end case
SIMILARITYBelongs to the chloride channel (TC 2.A.49) family. ClcB subfamily.

Keywords [?]

Gene Ontology [?]

GO:0005247; Molecular function:voltage-gated chloride channel activity
GO:0006821; Biological process:chloride transport
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam PF00654; Voltage_CLC; 1;
General Transmembrane; -; 9-11;

Features [?]

Additional information [?]

Size range 414-461 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments In view of recent findings for ClcA in E.coli, ClcB may also be an exchange transporter and not a voltage-gated channel.

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