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HAMAP rule MF_01203

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General rule information [?]

Accession MF_01203
Dates 8-FEB-2002 (Created)
19-NOV-2019 (Last updated, Version 34)
Name CLC_ClcB
Scope
Bacteria
Template P76175 (CLCB_ECOLI)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

case <OC:Enterobacterales>
Identifier
CLCB
Protein name
RecName: Full=Voltage-gated ClC-type chloride channel ClcB;
Gene name
clcB
else
Identifier
CLCL
Protein name
RecName: Full=Putative chloride channel protein ClcB-like;
end case

Comments [?]

case <OC:Enterobacterales>
Function Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response.
end case
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location Cell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
Subcellular location Cell inner membrane; Multi-pass membrane protein.
end case
Similarity Belongs to the chloride channel (TC 2.A.49) family. ClcB subfamily.

Keywords [?]

Transport
Ion transport
Ion channel
Voltage-gated channel
Chloride channel
Chloride
Membrane
case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
Cell membrane
Transmembrane
Transmembrane helix

Gene Ontology [?]

GO:0005247; Molecular function: voltage-gated chloride channel activity.
GO:0006821; Biological process: chloride transport.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam PF00654; Voltage_CLC; 1;
PRINTS PR00762; CLCHANNEL; 1;

Computed features [?]

General Transmembrane; -; 9-11; trigger=yes;

Additional information [?]

Size range 414-461 amino acids
Related rules None
Fusion None
Comments In view of recent findings for ClcA in E.coli, ClcB may also be an exchange transporter and not a voltage-gated channel.


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