HAMAP rule MF_01203

General rule information [?]

Accession	MF_01203
Dates	8-FEB-2002 (Created) 28-NOV-2023 (Last updated, Version 35)
Name	CLC_ClcB
Scope(s)	Bacteria
Template(s)	P76175 (CLCB_ECOLI); [ Recover all ]
Triggered by	HAMAP; MF_01203 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

case <OC:Enterobacterales>
Identifier	CLCB
Protein name	RecName: Full=Voltage-gated ClC-type chloride channel ClcB;
Gene name	Name=clcB;
else
Identifier	CLCL
Protein name	RecName: Full=Putative chloride channel protein ClcB-like;
end case

Comments [?]

case <OC:Enterobacterales>
FUNCTION	Probably acts as an electrical shunt for an outwardly- directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response.
end case
case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATION	Cell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
SUBCELLULAR LOCATION	Cell inner membrane; Multi-pass membrane protein.
end case
SIMILARITY	Belongs to the chloride channel (TC 2.A.49) family. ClcB subfamily.

Keywords [?]

Transport
Ion transport
Ion channel
Voltage-gated channel
Chloride channel
Chloride
Membrane
case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
Cell membrane
Transmembrane
Transmembrane helix

Gene Ontology [?]

GO:0005247; Molecular function:voltage-gated chloride channel activity

GO:0006821; Biological process:chloride transport

GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Features [?]

Additional information [?]

Size range	414-461 amino acids
Related rules	None
Fusion	Nter: None Cter: None
Comments	In view of recent findings for ClcA in E.coli, ClcB may also be an exchange transporter and not a voltage-gated channel.