HAMAP logo

HAMAP rule MF_01204

Send feedback

General rule information [?]

Accession MF_01204
Dates 7-MAR-2002 (Created)
12-JAN-2021 (Last updated, Version 31)
Name Oxidoreductase_RutE_HadB
Scope(s) Bacteria
Template(s) P75894 (RUTE_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01204 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

case <OC:Enterobacterales>
Identifier RUTE
Protein name RecName: Full=Probable malonic semialdehyde reductase RutE;
Gene name Name=rutE;
end case
case not <OC:Enterobacterales>
Identifier Ynnn
Protein name RecName: Full=Putative NADH dehydrogenase/NAD(P)H nitroreductase ;
end case

Comments [?]

case <OC:Enterobacterales>
FUNCTIONMay reduce toxic product malonic semialdehyde to 3- hydroxypropionic acid, which is excreted.
CATALYTIC ACTIVITY Reaction=3-hydroxypropanoate + NADP(+) = 3-oxopropanoate + H(+) + NADPH; Xref=Rhea:RHEA:26438, ChEBI:CHEBI:15378, ChEBI:CHEBI:16510, ChEBI:CHEBI:33190, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=;
end case
case <OC:Escherichia> or <OC:Shigella>
INDUCTIONUp-regulated by the nitrogen regulatory protein C (NtrC also called GlnG) and repressed by RutR.
end case
SIMILARITYBelongs to the nitroreductase family. HadB/RutE subfamily.

Keywords [?]

Gene Ontology [?]

case <OCellular component:Enterobacterales>
GO:0035527; Molecular function:3-hydroxypropionate dehydrogenase (NADP+) activity
GO:0006212; Biological process:uracil catabolic process
GO:0019740; Biological process:nitrogen utilization
end case
case not <OCellular component:Enterobacterales>
GO:0016491; Molecular function:oxidoreductase activity
end case

Cross-references [?]

Pfam PF00881; Nitroreductase; 1;

Features [?]

Additional information [?]

Size range 195-202 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments The rut operon for pyrimidine utilization seems to be absent in salmonellae.

View rule in raw text format (no links)