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HAMAP rule MF_01204

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General rule information [?]

Accession MF_01204
Dates 7-MAR-2002 (Created)
12-JAN-2021 (Last updated, Version 31)
Name Oxidoreductase_RutE_HadB
Scope
Bacteria
Template P75894 (RUTE_ECOLI)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

case <OC:Enterobacterales>
Identifier
RUTE
Protein name
RecName: Full=Probable malonic semialdehyde reductase RutE;
EC 1.1.1.298;
Gene name
rutE
end case
case not <OC:Enterobacterales>
Identifier
Ynnn
Protein name
RecName: Full=Putative NADH dehydrogenase/NAD(P)H nitroreductase ;
EC 1.-.-.-;
end case

Comments [?]

case <OC:Enterobacterales>
Function May reduce toxic product malonic semialdehyde to 3-hydroxypropionic acid, which is excreted.
Catalytic activity RHEA:26438: 3-hydroxypropanoate + NADP(+) = 3-oxopropanoate + H(+) + NADPH
EC 1.1.1.298
end case
Cofactor FMN
case <OC:Escherichia> or <OC:Shigella>
Induction Up-regulated by the nitrogen regulatory protein C (NtrC also called GlnG) and repressed by RutR.
end case
Similarity Belongs to the nitroreductase family. HadB/RutE subfamily.

Keywords [?]

Oxidoreductase
NAD
NADP
Flavoprotein
FMN

Gene Ontology [?]

case <OC:Enterobacterales>
GO:0035527; Molecular function: 3-hydroxypropionate dehydrogenase (NADP+) activity.
GO:0006212; Biological process: uracil catabolic process.
GO:0019740; Biological process: nitrogen utilization.
end case
case not <OC:Enterobacterales>
GO:0016491; Molecular function: oxidoreductase activity.
end case

Cross-references [?]

Pfam PF00881; Nitroreductase; 1;

Additional information [?]

Size range 195-202 amino acids
Related rules None
Fusion None
Comments The rut operon for pyrimidine utilization seems to be absent in salmonellae.


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