HAMAP rule MF_01204
General rule information
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| Accession | MF_01204 |
| Dates | 7-MAR-2002 (Created)
12-JAN-2021 (Last updated, Version 31) |
| Name | Oxidoreductase_RutE_HadB |
| Scope(s) |
Bacteria |
| Template(s) | P75894 (RUTE_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01204 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| case <OC:Enterobacterales> | |
| Identifier | RUTE |
| Protein name | RecName: Full=Probable malonic semialdehyde reductase RutE; EC=1.1.1.298; |
| Gene name | Name=rutE; |
| end case | |
| case not <OC:Enterobacterales> | |
| Identifier | Ynnn |
| Protein name | RecName: Full=Putative NADH dehydrogenase/NAD(P)H nitroreductase EC=1.-.-.-; |
| end case | |
Comments
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| case <OC:Enterobacterales> | |
| FUNCTION | May reduce toxic product malonic semialdehyde to 3- hydroxypropionic acid, which is excreted. |
| CATALYTIC ACTIVITY | Reaction=3-hydroxypropanoate + NADP(+) = 3-oxopropanoate + H(+) + NADPH; Xref=Rhea:RHEA:26438, ChEBI:CHEBI:15378, ChEBI:CHEBI:16510, ChEBI:CHEBI:33190, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.298; |
| end case | |
| COFACTOR | Name=FMN; Xref=ChEBI:CHEBI:58210; |
| case <OC:Escherichia> or <OC:Shigella> | |
| INDUCTION | Up-regulated by the nitrogen regulatory protein C (NtrC also called GlnG) and repressed by RutR. |
| end case | |
| SIMILARITY | Belongs to the nitroreductase family. HadB/RutE subfamily. |
Keywords
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Gene Ontology
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| case <OCellular component:Enterobacterales> | |
| GO:0035527; Molecular function:3-hydroxypropionate dehydrogenase (NADP+) activity | |
| GO:0006212; Biological process:uracil catabolic process | |
| GO:0019740; Biological process:nitrogen utilization | |
| end case | |
| case not <OCellular component:Enterobacterales> | |
| GO:0016491; Molecular function:oxidoreductase activity | |
| end case | |
Cross-references
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| Pfam | PF00881; Nitroreductase; 1; |
Features
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Additional information
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| Size range | 195-202 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | The rut operon for pyrimidine utilization seems to be absent in salmonellae. |