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Annotation rule MF_01206
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General rule information [?]

Accession MF_01206
Dates 15-MAR-2002 (Created)
19-NOV-2019 (Last updated, Version 32)
Name MsrP
Scope
Bacteria
Template P76342 (MSRP_ECOLI)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
MSRP
Protein name
RecName: Full=Protein-methionine-sulfoxide reductase catalytic subunit MsrP;
EC 1.8.5.-;
Flags: Precursor;
Gene name
msrP

Comments [?]

case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella>
Function Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation, including the primary periplasmic chaperone SurA and the lipoprotein Pal. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide.
else case <OC:Proteobacteria>
Function Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide.
else
Function Part of the MsrPQ system that repairs oxidized cell envelope proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated cell envelope proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide.
end case
Catalytic activity RHEA:51292: a quinone + H2O + L-methionyl-[protein] = a quinol + L-methionyl-(S)-S-oxide-[protein]
RHEA:51296: a quinone + H2O + L-methionyl-[protein] = a quinol + L-methionyl-(R)-S-oxide-[protein]
Cofactor Mo-molybdopterin
Note: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
Subunit Heterodimer of a catalytic subunit (MsrP) and a heme-binding subunit (MsrQ).
case defined <Property:Membrane> and <Property:Membrane=2>
Subcellular location Periplasm. Note=Is attached to the inner membrane when interacting with the MsrQ subunit.
end case
case <Property:Membrane=1> and <Feature:PS51318>
Subcellular location Cell envelope. Note=Is attached to the cell membrane when interacting with the MsrQ subunit.
Ptm Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.
else case <Feature:PS51318>
Ptm Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.
end case
Similarity Belongs to the MsrP family.

Keywords [?]

case defined <Property:Membrane> and <Property:Membrane=2>
end case

Gene Ontology [?]

GO:0016672; Molecular function: oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor.
GO:0043546; Molecular function: molybdopterin cofactor binding.
GO:0030091; Biological process: protein repair.
GO:0055114; Biological process: oxidation-reduction process.
case defined <Property:Membrane> and <Property:Membrane=2>
GO:0042597; Cellular component: periplasmic space.
end case

Cross-references [?]

Pfam PF00174; Oxidored_molyb; 1;
TIGRFAMs TIGR01409; TAT_signal_seq; 1;
PROSITE PS51318; TAT; 0-1; trigger=PRU00648;

Computed features [?]

case not <Feature:PS51318>
General Signal; -; 1; trigger=yes;
end case

Features [?]

From: MSRP_ECOLI (P76342)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     91     92       Molybdopterin binding     Y-E  
REGION     249     251       Molybdopterin binding     x-x-K  
METAL     146     146       Molybdenum     C  
BINDING (Optional)     88     88       Molybdopterin     N  
BINDING (Optional)     181     181       Molybdopterin     [TS]  
BINDING     233     233       Molybdopterin     N  
BINDING     238     238       Molybdopterin     R  

Additional information [?]

Size range 297-366 amino acids
Related rules None
Fusion None