HAMAP rule MF_01206

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_01206
Accession	MF_01206
Dates	28-FEB-2005 (Created) 03-SEP-2024 (Last updated, Version 34)
Name	MsrP
Scope(s)	Bacteria
Template(s)	P76342; [ Recover all ]
Triggered by	HAMAP; MF_01206 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	MSRP
Protein name	RecName: Full=Protein-methionine-sulfoxide reductase catalytic subunit MsrP; EC=1.8.5.-; Flags: Precursor;
Gene name	Name=msrP;

Comments [?]

case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella>
FUNCTION	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation, including the primary periplasmic chaperone SurA and the lipoprotein Pal. The catalytic subunit MsrP is non- stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide.
else case <OC:Pseudomonadota>
FUNCTION	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide.
else
FUNCTION	Part of the MsrPQ system that repairs oxidized cell envelope proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated cell envelope proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide.
end case
CATALYTIC ACTIVITY	Reaction=L-methionyl-[protein] + a quinone + H2O = L-methionyl-(S)-S- oxide-[protein] + a quinol; Xref=Rhea:RHEA:51292, Rhea:RHEA- COMP:12313, Rhea:RHEA-COMP:12315, ChEBI:CHEBI:15377, ChEBI:CHEBI:16044, ChEBI:CHEBI:24646, ChEBI:CHEBI:44120, ChEBI:CHEBI:132124;
CATALYTIC ACTIVITY	Reaction=L-methionyl-[protein] + a quinone + H2O = L-methionyl-(R)-S- oxide-[protein] + a quinol; Xref=Rhea:RHEA:51296, Rhea:RHEA- COMP:12313, Rhea:RHEA-COMP:12314, ChEBI:CHEBI:15377, ChEBI:CHEBI:16044, ChEBI:CHEBI:24646, ChEBI:CHEBI:45764, ChEBI:CHEBI:132124;
COFACTOR	Name=Mo-molybdopterin; Xref=ChEBI:CHEBI:71302; Note=Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.;
SUBUNIT	Heterodimer of a catalytic subunit (MsrP) and a heme-binding subunit (MsrQ).
case defined <Property:Membrane> and <Property:Membrane=2>
SUBCELLULAR LOCATION	Periplasm. Note=Is attached to the inner membrane when interacting with the MsrQ subunit.
end case
case <Property:Membrane=1> and <Feature:PS51318>
SUBCELLULAR LOCATION	Cell envelope. Note=Is attached to the cell membrane when interacting with the MsrQ subunit.
PTM	Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.
else case <Feature:PS51318>
PTM	Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.
end case
SIMILARITY	Belongs to the MsrP family.

Keywords [?]

Metal-binding
Molybdenum
Oxidoreductase
case defined <Property:Membrane> and <Property:Membrane=2>
Periplasm
end case
Signal

Gene Ontology [?]

GO:0016672; Molecular function:oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor
GO:0043546; Molecular function:molybdopterin cofactor binding
GO:0030091; Biological process:protein repair
case defined <Property:Membrane> and <Property:Membrane=2>
GO:0042597; Cellular component:periplasmic space
end case

Cross-references [?]

Pfam	PF00174; Oxidored_molyb; 1;
NCBIfam	TIGR01409; TAT_signal_seq; 1;
PROSITE	PS51318; TAT; 0-1;
General	Signal; -; 1;

Features [?]

From: MSRP_ECOLI (P76342)

Key

From

Description

Tag

Condition

FTGroup

BINDING