HAMAP rule MF_01215
General rule information
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| Accession | MF_01215 |
| Dates | 10-JUN-2002 (Created)
14-MAY-2024 (Last updated, Version 27) |
| Name | OMPdecase_type2 |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P0A5M7 (PYRF_MYCBO); P96076 (PYRF_THET2); [ Recover all ] |
| Triggered by |
HAMAP; MF_01215 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | PYRF |
| RecName: Full=Orotidine 5'-phosphate decarboxylase;<br /> EC=<a href="https://enzyme.expasy.org/EC/4.1.1.23">4.1.1.23</a>;<br /> AltName: Full=OMP decarboxylase;<br /> Short=OMPDCase;<br /> Short=OMPdecase; | |
| Gene name | Name=pyrF; |
Comments
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| CATALYTIC ACTIVITY | Reaction=H(+) + orotidine 5'-phosphate = CO2 + UMP; Xref=Rhea:RHEA:11596, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57538, ChEBI:CHEBI:57865; EC=4.1.1.23; |
| PATHWAY | Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2. |
| SIMILARITY | Belongs to the OMP decarboxylase family. Type 2 subfamily. |
Keywords
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Gene Ontology
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| GO:0004590; Molecular function:orotidine-5'-phosphate decarboxylase activity |
| GO:0044205; Biological process:'de novo' UMP biosynthetic process |
Cross-references
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Features
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| From: PYRF_DEIRA (Q9RSC5) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 92 | 92 | /note="Proton donor" | K | ||||||||
Additional information
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| Size range | 267-307 amino acids |
| Related rules |
MF_01200 |
| Fusion | Nter: None Cter: MF_01208 (pyrE) |
| Comments | Divergent NOSS1; sequence not included in alignment |