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HAMAP rule MF_01215

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General rule information [?]

Accession MF_01215
Dates 10-JUN-2002 (Created)
1-JUN-2023 (Last updated, Version 26)
Name OMPdecase_type2
Scope(s) Bacteria
Template(s) P0A5M7 (PYRF_MYCBO); P96076 (PYRF_THET2); [ Recover all ]
Triggered by HAMAP; MF_01215 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier PYRF
RecName: Full=Orotidine 5'-phosphate decarboxylase;<br /> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;EC=<a href="https://enzyme.expasy.org/EC/"></a>;<br /> AltName: Full=OMP decarboxylase;<br /> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Short=OMPDCase;<br /> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Short=OMPdecase;
Gene name Name=pyrF;

Comments [?]

CATALYTIC ACTIVITY Reaction=H(+) + orotidine 5'-phosphate = CO2 + UMP; Xref=Rhea:RHEA:11596, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57538, ChEBI:CHEBI:57865; EC=;
PATHWAYPyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.
SIMILARITYBelongs to the OMP decarboxylase family. Type 2 subfamily.

Keywords [?]

Gene Ontology [?]

GO:0004590; Molecular function:orotidine-5'-phosphate decarboxylase activity
GO:0006221; Biological process:pyrimidine nucleotide biosynthetic process

Cross-references [?]

Pfam PF00215; OMPdecase; 1;
NCBIfam TIGR02127; pyrF_sub2; 1;

Features [?]

Key From To Description Tag Condition FTGroup
ACT_SITE 92 92 /note="Proton donor" K

Additional information [?]

Size range 267-307 amino acids
Related rules MF_01200
Fusion Nter: None Cter: MF_01208 (pyrE)
Comments Divergent NOSS1; sequence not included in alignment

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