HAMAP rule MF_01215

General rule information [?]

Accession	MF_01215
Dates	10-JUN-2002 (Created) 19-NOV-2019 (Last updated, Version 25)

Name	OMPdecase_type2

Scope

Bacteria

Archaea

Templates

P0A5M7 (PYRF_MYCBO); P96076 (PYRF_THET2): [Recover all]

Triggered by

HAMAP; MF_01215 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

PYRF

Protein name

RecName:		Full=Orotidine 5'-phosphate decarboxylase;
		EC 4.1.1.23;
AltName:		Full=OMP decarboxylase;
		Short=OMPDCase;
		Short=OMPdecase;

Gene name

pyrF

Comments [?]

Catalytic activity	RHEA:11596: H(+) + orotidine 5'-phosphate = CO2 + UMP EC 4.1.1.23
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.
Similarity	Belongs to the OMP decarboxylase family. Type 2 subfamily.

Keywords [?]

Lyase
Decarboxylase
Pyrimidine biosynthesis

Gene Ontology [?]

GO:0004590; Molecular function: orotidine-5'-phosphate decarboxylase activity.
GO:0006221; Biological process: pyrimidine nucleotide biosynthetic process.

Cross-references [?]

Pfam	PF00215; OMPdecase; 1;
PROSITE	PS00156; OMPDECASE; 1;
TIGRFAMs	TIGR02127; pyrF_sub2; 1;

Features [?]

From: PYRF_DEIRA (Q9RSC5)

Key From To Description Tag Condition FTGroup

ACT_SITE 92 92 Proton donor K

Additional information [?]

Size range	267-307 amino acids
Related rules	MF_01200 (PYRF)
Fusion	Nter: None; Cter: MF_01208 (pyrE)
Comments	Divergent NOSS1; sequence not included in alignment

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