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Annotation rule MF_01219
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General rule information [?]

Accession MF_01219
Dates 28-AUG-2002 (Created)
19-NOV-2019 (Last updated, Version 26)
Name PyrR
Scope
Bacteria
Templates P39765 (PYRR_BACSU); P41007 (PYRR_BACCL); F2MMP6 (PYRR_ENTFO): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
PYRR
Protein name
RecName: Full=Bifunctional protein PyrR;
Includes:
RecName: Full=Pyrimidine operon regulatory protein;
Includes:
RecName: Full=Uracil phosphoribosyltransferase;
Short=UPRTase;
EC 2.4.2.9;
Gene name
pyrR

Comments [?]

case <OC:Firmicutes>
Function Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes.
end case
case not <OC:Firmicutes>
Function Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.
end case
Function Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
Catalytic activity RHEA:13017: diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil
EC 2.4.2.9
case <OC:Firmicutes>
Subunit Homodimer and homohexamer; in equilibrium.
end case
Similarity Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.

Keywords [?]

Transcription
case <OC:Firmicutes>
Transcription regulation
Transcription termination
RNA-binding
end case
case not <OC:Firmicutes>
Transcription regulation
end case
Transferase
Glycosyltransferase

Gene Ontology [?]

case <OC:Firmicutes>
GO:0003723; Molecular function: RNA binding.
end case
GO:0004845; Molecular function: uracil phosphoribosyltransferase activity.
case not <OC:Firmicutes>
GO:0006355; Biological process: regulation of transcription, DNA-templated.
end case
case <OC:Firmicutes>
GO:0006353; Biological process: DNA-templated transcription, termination.
end case

Cross-references [?]

Pfam PF00156; Pribosyltran; 1;
PROSITE PS00103; PUR_PYR_PR_TRANSFER; 1;

Features [?]

From: PYRR_BACSU (P39765)
Key     From     To       Description   Tag   Condition   FTGroup
MOTIF     101     113       PRPP-binding        

Additional information [?]

Size range 168-193 amino acids
Related rules None
Fusion None


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