HAMAP rule MF_01219
General rule information
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| Accession | MF_01219 |
| Dates | 28-AUG-2002 (Created)
3-SEP-2024 (Last updated, Version 29) |
| Name | PyrR |
| Scope(s) |
Bacteria |
| Template(s) | P39765 (PYRR_BACSU); P41007 (PYRR_BACCL); F2MMP6 (PYRR_ENTFO); [ Recover all ] |
| Triggered by |
HAMAP; MF_01219 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | PYRR |
| Protein name | RecName: Full=Bifunctional protein PyrR; Includes: RecName: Full=Pyrimidine operon regulatory protein; Includes: RecName: Full=Uracil phosphoribosyltransferase; Short=UPRTase; EC=2.4.2.9; |
| Gene name | Name=pyrR; |
Comments
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| case <OC:Bacillota> | |
| FUNCTION | Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes. |
| end case | |
| case not <OC:Bacillota> | |
| FUNCTION | Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines. |
| end case | |
| FUNCTION | Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant. |
| CATALYTIC ACTIVITY | Reaction=UMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + uracil; Xref=Rhea:RHEA:13017, ChEBI:CHEBI:17568, ChEBI:CHEBI:33019, ChEBI:CHEBI:57865, ChEBI:CHEBI:58017; EC=2.4.2.9; |
| case <OC:Bacillota> | |
| SUBUNIT | Homodimer and homohexamer; in equilibrium. |
| end case | |
| SIMILARITY | Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. |
Keywords
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| Transcription | |
| case <OC:Bacillota> | |
| Transcription regulation | |
| Transcription termination | |
| RNA-binding | |
| end case | |
| case not <OC:Bacillota> | |
| Transcription regulation | |
| end case | |
| Transferase | |
| Glycosyltransferase | |
Gene Ontology
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| case <OCellular component:Bacillota> | |
| GO:0003723; Molecular function:RNA binding | |
| end case | |
| GO:0004845; Molecular function:uracil phosphoribosyltransferase activity | |
| case not <OCellular component:Bacillota> | |
| GO:0006355; Biological process:regulation of DNA-templated transcription | |
| end case | |
| case <OCellular component:Bacillota> | |
| GO:0006353; Biological process:DNA-templated transcription termination | |
| end case | |
Cross-references
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Features
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| From: PYRR_BACSU (P39765) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| MOTIF | 101 | 113 | /note="PRPP-binding" | |||||||||
Additional information
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| Size range | 168-193 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |