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HAMAP rule MF_01219

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General rule information [?]

Accession MF_01219
Dates 28-AUG-2002 (Created)
13-JAN-2023 (Last updated, Version 28)
Name PyrR
Scope(s) Bacteria
Template(s) P39765 (PYRR_BACSU); P41007 (PYRR_BACCL); F2MMP6 (PYRR_ENTFO); [ Recover all ]
Triggered by HAMAP; MF_01219 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier PYRR
Protein name RecName: Full=Bifunctional protein PyrR;
RecName: Full=Pyrimidine operon regulatory protein;
RecName: Full=Uracil phosphoribosyltransferase;
Gene name Name=pyrR;

Comments [?]

case <OC:Bacillota>
FUNCTIONRegulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes.
end case
case not <OC:Bacillota>
FUNCTIONRegulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.
end case
FUNCTIONAlso displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
CATALYTIC ACTIVITY Reaction=diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil; Xref=Rhea:RHEA:13017, ChEBI:CHEBI:17568, ChEBI:CHEBI:33019, ChEBI:CHEBI:57865, ChEBI:CHEBI:58017; EC=;
case <OC:Bacillota>
SUBUNITHomodimer and homohexamer; in equilibrium.
end case
SIMILARITYBelongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.

Keywords [?]

Gene Ontology [?]

case <OCellular component:Bacillota>
GO:0003723; Molecular function:RNA binding
end case
GO:0004845; Molecular function:uracil phosphoribosyltransferase activity
case not <OCellular component:Bacillota>
GO:0006355; Biological process:regulation of DNA-templated transcription
end case
case <OCellular component:Bacillota>
GO:0006353; Biological process:DNA-templated transcription termination
end case

Cross-references [?]

Pfam PF00156; Pribosyltran; 1;

Features [?]

From: PYRR_BACSU (P39765)
Key From To Description Tag Condition FTGroup
MOTIF 101 113 /note="PRPP-binding"

Additional information [?]

Size range 168-193 amino acids
Related rules None
Fusion Nter: None Cter: None

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