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Annotation rule MF_01219 |
General rule information
[?]
Accession |
MF_01219 |
Dates |
28-AUG-2002 (Created) 19-NOV-2019 (Last updated, Version 26) |
Propagated annotation
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Identifier, protein and gene names
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Protein name |
RecName:
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Full=Bifunctional protein PyrR;
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Includes:
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RecName:
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Full=Pyrimidine operon regulatory protein;
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Includes:
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RecName:
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Full=Uracil phosphoribosyltransferase;
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Short=UPRTase;
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EC 2.4.2.9;
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case <OC:Firmicutes>
Function |
Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes. |
end case
case not <OC:Firmicutes>
Function |
Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines. |
end case
Function |
Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant. |
Catalytic activity |
RHEA:13017: diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil
EC 2.4.2.9
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case <OC:Firmicutes>
Subunit |
Homodimer and homohexamer; in equilibrium. |
end case
Similarity |
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. |
case <OC:Firmicutes>
end case
case not <OC:Firmicutes>
end case
case <OC:Firmicutes>
end case
GO:0004845; Molecular function: uracil phosphoribosyltransferase activity.
case not <OC:Firmicutes>
GO:0006355; Biological process: regulation of transcription, DNA-templated.
end case
case <OC:Firmicutes>
GO:0006353; Biological process: DNA-templated transcription, termination.
end case
Pfam |
PF00156; Pribosyltran; 1; |
PROSITE |
PS00103; PUR_PYR_PR_TRANSFER; 1; |
From: PYRR_BACSU (P39765) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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MOTIF
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101
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113
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PRPP-binding
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Additional information
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Size range |
168-193 amino acids |
Related rules |
None |
Fusion |
None |