HAMAP rule MF_01224
General rule information
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| Accession | MF_01224 |
| Dates | 4-SEP-2002 (Created)
1-JUN-2023 (Last updated, Version 28) |
| Name | MoaC |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P0A738 (MOAC_ECOLI); Q2FVX9 (MOAC_STAA8); [ Recover all ] |
| Triggered by |
case c? <OC:Bacteria>
HAMAP; MF_01224_B (Get profile general information and statistics) end case
case c? <OC:Archaea>
HAMAP; MF_01224_A (Get profile general information and statistics) end case
|
Propagated annotation
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Identifier, protein and gene names
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| Identifier | MOAC |
| case <OC:Bacteria> | |
| Protein name | RecName: Full=Cyclic pyranopterin monophosphate synthase; EC=4.6.1.17; AltName: Full=Molybdenum cofactor biosynthesis protein C; |
| end case | |
| case <OC:Archaea> | |
| Protein name | RecName: Full=Probable cyclic pyranopterin monophosphate synthase; EC=4.6.1.17; AltName: Full=Molybdenum cofactor biosynthesis protein C; |
| end case | |
| Gene name | Name=moaC; |
Comments
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| FUNCTION | Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP). |
| CATALYTIC ACTIVITY | Reaction=(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate; Xref=Rhea:RHEA:49580, ChEBI:CHEBI:33019, ChEBI:CHEBI:59648, ChEBI:CHEBI:131766; EC=4.6.1.17; |
| PATHWAY | Cofactor biosynthesis; molybdopterin biosynthesis. |
| SUBUNIT | Homohexamer; trimer of dimers. |
| SIMILARITY | Belongs to the MoaC family. |
Keywords
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Gene Ontology
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| GO:0061799; Molecular function:cyclic pyranopterin monophosphate synthase activity |
| GO:0006777; Biological process:Mo-molybdopterin cofactor biosynthetic process |
Cross-references
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Features
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| From: MOAC_ECOLI (P0A738) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case <OC:Bacteria> | ||||||||||||
| BINDING | 75 | 77 | /ligand="substrate" | [LMYF]-x-H | ||||||||
| BINDING | 113 | 114 | /ligand="substrate" | [MI]-E | ||||||||
| ACT_SITE | 128 | 128 | D | |||||||||
| end case | ||||||||||||
| From: MOAC_METTH (O26900) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case <OC:Archaea> | ||||||||||||
| BINDING | 77 | 79 | /ligand="substrate" | [LMY]-x-H | ||||||||
| BINDING | 113 | 114 | /ligand="substrate" | M-[ED] | ||||||||
| ACT_SITE | 128 | 128 | D | |||||||||
| end case | ||||||||||||
Additional information
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| Size range | 143-163 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: MF_01226 (moaB); MF_00316 (mobA); <Unknown> |
| Comments | Divergent PYRAE; sequence not included in alignment and not taken into account in size range. Unknown C-terminal domain in AQUAE. |