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Annotation rule MF_01224
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General rule information [?]

Accession MF_01224
Dates 4-SEP-2002 (Created)
19-NOV-2019 (Last updated, Version 25)
Name MoaC
Scope
Bacteria
Archaea
Templates P0A738 (MOAC_ECOLI); Q2FVX9 (MOAC_STAA8): [Recover all]
case <OC:Bacteria>
Triggered by
end case

case <OC:Archaea>
Triggered by
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
MOAC
case <OC:Bacteria>
Protein name
RecName: Full=Cyclic pyranopterin monophosphate synthase;
EC 4.6.1.17;
AltName: Full=Molybdenum cofactor biosynthesis protein C;
end case
case <OC:Archaea>
Protein name
RecName: Full=Probable cyclic pyranopterin monophosphate synthase;
EC 4.6.1.17;
AltName: Full=Molybdenum cofactor biosynthesis protein C;
end case
Gene name
moaC

Comments [?]

Function Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
Catalytic activity RHEA:49580: (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate
EC 4.6.1.17
Pathway Cofactor biosynthesis; molybdopterin biosynthesis.
Subunit Homohexamer; trimer of dimers.
Similarity Belongs to the MoaC family.

Keywords [?]

Lyase
Molybdenum cofactor biosynthesis

Gene Ontology [?]

GO:0061799; Molecular function: cyclic pyranopterin monophosphate synthase activity.
GO:0006777; Biological process: Mo-molybdopterin cofactor biosynthetic process.

Cross-references [?]

Pfam PF01967; MoaC; 1;
TIGRFAMs TIGR00581; MoaC; 1;

Features [?]

case <OC:Bacteria>
From: MOAC_ECOLI (P0A738)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     75     77       Substrate binding     [LMYF]-x-H  
REGION     113     114       Substrate binding     [MI]-E  
ACT_SITE     128     128             D  
end case
case <OC:Archaea>
From: MOAC_METTH (O26900)
REGION     77     79       Substrate binding     [LMY]-x-H  
REGION     113     114       Substrate binding     M-[ED]  
ACT_SITE     128     128             D  
end case

Additional information [?]

case <OC:Bacteria>
Size range 155-177 amino acids
end case
case <OC:Archaea>
Size range 143-163 amino acids
end case
Related rules None
Fusion Nter: None; Cter: MF_01226 (moaB), MF_00316 (mobA), <Unknown>
Comments Divergent PYRAE; sequence not included in alignment and not taken into account in size range. Unknown C-terminal domain in AQUAE.


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