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Annotation rule MF_01228 |
General rule information
[?]
Accession |
MF_01228 |
Dates |
30-OCT-2002 (Created) 19-NOV-2019 (Last updated, Version 38) |
Name |
Met_tRNA_synth_type2 |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Protein name |
RecName:
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Full=Methionine--tRNA ligase;
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EC 6.1.1.10;
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AltName:
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Full=Methionyl-tRNA synthetase;
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Short=MetRS;
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Function |
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. |
Catalytic activity |
RHEA:13481: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)
EC 6.1.1.10
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case <FT:3> and <FT:4> and <FT:5> and (<FT:6> or <FT:7> or <FT:8>)
Cofactor |
Zn(2+) Note: Binds 1 zinc ion per subunit. |
end case
case <Feature:PS50886>
end case
case not <Feature:PS50886> and <OC:Bacteria>
end case
Subcellular location |
Cytoplasm. |
case <FT:3> and <FT:4> and <FT:5> and (<FT:6> or <FT:7> or <FT:8>)
Similarity |
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily. |
end case
case not <FT:3>
Similarity |
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily. |
end case
case <Feature:PS50886>
end case
case <FT:3> and <FT:4> and <FT:5> and (<FT:6> or <FT:7> or <FT:8>)
end case
GO:0005524; Molecular function: ATP binding.
GO:0004825; Molecular function: methionine-tRNA ligase activity.
GO:0006431; Biological process: methionyl-tRNA aminoacylation.
GO:0005737; Cellular component: cytoplasm.
From: SYM_THET8 (P23395) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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MOTIF
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12
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22
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'HIGH' region
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[YDFAS]-Y-x(5)-H-[LIV]-G-[SHN]
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MOTIF
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297
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301
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'KMSKS' region
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K-[MI]-[SG]-K-[ST]
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METAL
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127
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127
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Zinc
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C
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METAL
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130
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130
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Zinc
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C
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METAL
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144
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144
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Zinc
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C
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METAL
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147
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147
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Zinc
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[HC]
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case not <FT:6>
From: SYM_SYNY3 (Q55729) |
METAL
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152
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152
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Zinc
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[HC]
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end case
case not <FT:7>
From: SYM_MYCGE (P47267) |
METAL
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147
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147
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Zinc
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[HC]
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end case
Additional information
[?]
Size range |
497-683 amino acids |
Related rules |
MF_00098 (SYM) |
Fusion |
None |
Comments |
Subfamily 2a links 1 zinc ion ion (shown in THET8) whereas subfamily 2b does not (shown in MYCTU). Possible wrong starts in AQUAE and SYNY3. |