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HAMAP rule MF_01234

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General rule information [?]

Accession MF_01234
Dates 24-MAR-2003 (Created)
19-NOV-2022 (Last updated, Version 27)
Name ManNAc_kinase
Template P45425 (NANK_ECOLI)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=N-acetylmannosamine kinase;
AltName: Full=ManNAc kinase;
AltName: Full=N-acetyl-D-mannosamine kinase;
Gene name

Comments [?]

Function Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P.
Catalytic activity RHEA:23832: an N-acyl-D-mannosamine + ATP = ADP + an N-acyl-D-mannosamine 6-phosphate + H(+)
Pathway Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate: step 2/5.
Subunit Homodimer.
Similarity Belongs to the ROK (NagC/XylR) family. NanK subfamily.

Keywords [?]

case <FTGroup:1>
end case

Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
case <FTGroup:1>
GO:0008270; Molecular function: zinc ion binding.
end case
GO:0009384; Molecular function: N-acylmannosamine kinase activity.
GO:0005975; Biological process: carbohydrate metabolic process.
GO:0006051; Biological process: N-acetylmannosamine metabolic process.

Cross-references [?]

Pfam PF00480; ROK; 1;
PROSITE PS01125; ROK; 1;

Features [?]

From: NANK_ECOLI (P45425)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     5     12       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616        
BINDING     132     139       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616        
BINDING     156     156       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     H   1
BINDING     166     166       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     C   1
BINDING     168     168       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     C   1
BINDING     173     173       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     C   1

Additional information [?]

Size range 287-300 amino acids
Related rules None
Fusion Nter: MF_01235 (nanE); Cter: None