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HAMAP rule MF_01234

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General rule information [?]

Accession MF_01234
Dates 24-MAR-2003 (Created)
19-NOV-2022 (Last updated, Version 27)
Name ManNAc_kinase
Scope(s) Bacteria
Template(s) P45425 (NANK_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01234 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier NANK
Protein name RecName: Full=N-acetylmannosamine kinase;
AltName: Full=ManNAc kinase;
AltName: Full=N-acetyl-D-mannosamine kinase;
Gene name Name=nanK;

Comments [?]

FUNCTIONCatalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P.
CATALYTIC ACTIVITY Reaction=an N-acyl-D-mannosamine + ATP = ADP + an N-acyl-D-mannosamine 6-phosphate + H(+); Xref=Rhea:RHEA:23832, ChEBI:CHEBI:15378, ChEBI:CHEBI:16062, ChEBI:CHEBI:30616, ChEBI:CHEBI:57666, ChEBI:CHEBI:456216; EC=;
PATHWAYAmino-sugar metabolism; N-acetylneuraminate degradation; D- fructose 6-phosphate from N-acetylneuraminate: step 2/5.
SIMILARITYBelongs to the ROK (NagC/XylR) family. NanK subfamily.

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding
case <FTGroup:1>
GO:0008270; Molecular function:zinc ion binding
end case
GO:0009384; Molecular function:N-acylmannosamine kinase activity
GO:0005975; Biological process:carbohydrate metabolic process
GO:0006051; Biological process:N-acetylmannosamine metabolic process

Cross-references [?]

Pfam PF00480; ROK; 1;
PROSITE PS01125; ROK; 1;

Features [?]

From: NANK_ECOLI (P45425)
Key From To Description Tag Condition FTGroup
BINDING 5 12 /ligand="ATP"
BINDING 132 139 /ligand="ATP"
BINDING 156 156 /ligand="Zn(2+)"
H 1
BINDING 166 166 /ligand="Zn(2+)"
C 1
BINDING 168 168 /ligand="Zn(2+)"
C 1
BINDING 173 173 /ligand="Zn(2+)"
C 1

Additional information [?]

Size range 287-300 amino acids
Related rules None
Fusion Nter: MF_01235 (nanE) Cter: None

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