HAMAP rule MF_01234
General rule information
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| Accession | MF_01234 |
| Dates | 24-MAR-2003 (Created)
19-NOV-2022 (Last updated, Version 27) |
| Name | ManNAc_kinase |
| Scope(s) |
Bacteria |
| Template(s) | P45425 (NANK_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01234 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | NANK |
| Protein name | RecName: Full=N-acetylmannosamine kinase; EC=2.7.1.60; AltName: Full=ManNAc kinase; AltName: Full=N-acetyl-D-mannosamine kinase; |
| Gene name | Name=nanK; |
Comments
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| FUNCTION | Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P. |
| CATALYTIC ACTIVITY | Reaction=an N-acyl-D-mannosamine + ATP = ADP + an N-acyl-D-mannosamine 6-phosphate + H(+); Xref=Rhea:RHEA:23832, ChEBI:CHEBI:15378, ChEBI:CHEBI:16062, ChEBI:CHEBI:30616, ChEBI:CHEBI:57666, ChEBI:CHEBI:456216; EC=2.7.1.60; |
| PATHWAY | Amino-sugar metabolism; N-acetylneuraminate degradation; D- fructose 6-phosphate from N-acetylneuraminate: step 2/5. |
| SUBUNIT | Homodimer. |
| SIMILARITY | Belongs to the ROK (NagC/XylR) family. NanK subfamily. |
Keywords
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| Carbohydrate metabolism | |
| Transferase | |
| Kinase | |
| ATP-binding | |
| Nucleotide-binding | |
| case <FTGroup:1> | |
| Metal-binding | |
| Zinc | |
| end case | |
Gene Ontology
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| GO:0005524; Molecular function:ATP binding | |
| case <FTGroup:1> | |
| GO:0008270; Molecular function:zinc ion binding | |
| end case | |
| GO:0009384; Molecular function:N-acylmannosamine kinase activity | |
| GO:0005975; Biological process:carbohydrate metabolic process | |
| GO:0006051; Biological process:N-acetylmannosamine metabolic process | |
Cross-references
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Features
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| From: NANK_ECOLI (P45425) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 5 | 12 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
|||||||||
| BINDING | 132 | 139 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
|||||||||
| BINDING | 156 | 156 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
H | 1 | |||||||
| BINDING | 166 | 166 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| BINDING | 168 | 168 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| BINDING | 173 | 173 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
Additional information
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| Size range | 287-300 amino acids |
| Related rules |
None |
| Fusion | Nter: MF_01235 (nanE) Cter: None |