HAMAP rule MF_01234
General rule information
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Accession | MF_01234 |
Dates | 24-MAR-2003 (Created) 19-NOV-2022 (Last updated, Version 27) |
Name | ManNAc_kinase |
Scope | Bacteria |
Template | P45425 (NANK_ECOLI) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
|
Protein name |
|
Gene name |
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Comments
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Function | Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P. |
Catalytic activity | RHEA:23832: an N-acyl-D-mannosamine + ATP = ADP + an N-acyl-D-mannosamine 6-phosphate + H(+)
EC 2.7.1.60 |
Pathway | Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate: step 2/5. |
Subunit | Homodimer. |
Similarity | Belongs to the ROK (NagC/XylR) family. NanK subfamily. |
Keywords
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case <FTGroup:1>
end case
Gene Ontology
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GO:0005524; Molecular function: ATP binding.
case <FTGroup:1>
GO:0008270; Molecular function: zinc ion binding.
end case
GO:0009384; Molecular function: N-acylmannosamine kinase activity.
GO:0005975; Biological process: carbohydrate metabolic process.
GO:0006051; Biological process: N-acetylmannosamine metabolic process.
GO:0005975; Biological process: carbohydrate metabolic process.
GO:0006051; Biological process: N-acetylmannosamine metabolic process.
Cross-references
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Features
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From: NANK_ECOLI (P45425) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 5 | 12 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | |||||||||
BINDING | 132 | 139 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | |||||||||
BINDING | 156 | 156 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 | H | 1 | |||||||
BINDING | 166 | 166 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 | C | 1 | |||||||
BINDING | 168 | 168 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 | C | 1 | |||||||
BINDING | 173 | 173 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 | C | 1 |
Additional information
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Size range | 287-300 amino acids |
Related rules | None |
Fusion | Nter: MF_01235 (nanE); Cter: None |