HAMAP rule MF_01235

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_01235
Accession	MF_01235
Dates	28-FEB-2005 (Created) 20-NOV-2025 (Last updated, Version )
Name	ManNAc6P_epimer
Scope(s)	Bacteria
Template(s)	Q2FJU6; Q8XNZ3; Q8RDN5; Q9KR62; P0A761; [ Recover all ]
Triggered by	HAMAP; MF_01235 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	NANE
Protein name	RecName: Full=N-acetylmannosamine-6-phosphate 2-epimerase; EC=5.1.3.9; AltName: Full=ManNAc-6-P epimerase;
Gene name	Name=nanE;

Comments [?]

FUNCTION	Epimerase involved in the degradation of sialic acid. Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N- acetylglucosamine-6-phosphate (GlcNAc-6-P).
CATALYTIC ACTIVITY	Reaction=an N-acyl-D-glucosamine 6-phosphate = an N-acyl-D-mannosamine 6-phosphate; Xref=Rhea:RHEA:23932, ChEBI:CHEBI:57599, ChEBI:CHEBI:57666; EC=5.1.3.9; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:23934; Evidence=;
CATALYTIC ACTIVITY	Reaction=N-acetyl-D-glucosamine 6-phosphate = aldehydo-N-acetyl-D- mannosamine 6-phosphate; Xref=Rhea:RHEA:25257, ChEBI:CHEBI:57513, ChEBI:CHEBI:58557; EC=5.1.3.9; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:25259; Evidence=;
PATHWAY	Amino-sugar metabolism; N-acetylneuraminate degradation; D- fructose 6-phosphate from N-acetylneuraminate: step 3/5.
SUBUNIT	Homodimer.
SIMILARITY	Belongs to the NanE family.

Keywords [?]

Gene Ontology [?]

GO:0016857; Molecular function:racemase and epimerase activity, acting on carbohydrates and derivatives

GO:0005975; Biological process:carbohydrate metabolic process

GO:0019262; Biological process:N-acetylneuraminate catabolic process

Cross-references [?]

Pfam	PF04131; NanE; 1;
NCBIfam	NF002231; PRK01130.1; 1;

Features [?]

From: NANE_STAA3 (Q2FJU6)

Key

From

Description

Tag

Condition

FTGroup

ACT_SITE

/note="Proton acceptor"

ACT_SITE

180

/note="Proton donor"

BINDING