HAMAP rule MF_01237

Accession	MF_01237
Dates	21-MAR-2003 (Created) 1-JUN-2023 (Last updated, Version 35)

Name	N_acetylneuram_lyase

Scope

Bacteria

Templates

P0A6L4 (NANA_ECOLI); P44539 (NANA_HAEIN); Q9S4K9 (NANA_CLOPE); Q2G160 (NANA_STAA8); P59407 (NANA_LACPL); Q6GK01 (NANA_STAAR): [Recover all]

Triggered by

HAMAP; MF_01237 (Get profile general information and statistics)

Identifier

NANA

Protein name

RecName: Full=N-acetylneuraminate lyase; Short=Neu5Ac lyase; Short=NAL; EC 4.1.3.3; AltName: Full=N-acetylneuraminate pyruvate-lyase; AltName: Full=N-acetylneuraminic acid aldolase; AltName: Full=Sialate lyase; AltName: Full=Sialic acid aldolase; AltName: Full=Sialic acid lyase;

Gene name

nanA

Function	Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate.
Catalytic activity	RHEA:23296: aceneuramate = N-acetyl-D-mannosamine + pyruvate EC 4.1.3.3
Pathway	Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate: step 1/5.
Subunit	Homotetramer.
Subcellular location	Cytoplasm.
Similarity	Belongs to the DapA family. NanA subfamily.

Cytoplasm
Carbohydrate metabolism
Lyase
Schiff base

GO:0008747; Molecular function: N-acetylneuraminate lyase activity.
GO:0005975; Biological process: carbohydrate metabolic process.
GO:0005737; Cellular component: cytoplasm.

Pfam	PF00701; DHDPS; 1;
PRINTS	PR00146; DHPICSNTHASE; 1;
NCBIfam	TIGR00683; NanA; 1;
PROSITE	PS00665; DHDPS_1; 1;
	PS00666; DHDPS_2; 1;

From: NANA_ECOLI (P0A6L4)

Key

From

To

Description

Tag

Condition

FTGroup

BINDING

47

48

/ligand="substrate

S-[TS]

ACT_SITE

165

165

Schiff-base intermediate with substrate

K

SITE

137

137

Involved in proton transfer during cleavage

Y

Size range	288-305 amino acids
Related rules	MF_00418 (DAPA); MF_00694 (KDGD)
Fusion	None

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