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Annotation rule MF_01237 |
Accession | MF_01237 |
Dates | 21-MAR-2003 (Created) 19-NOV-2019 (Last updated, Version 31) |
Name | N_acetylneuram_lyase |
Scope | Bacteria |
Templates | P0A6L4 (NANA_ECOLI); P44539 (NANA_HAEIN); Q9S4K9 (NANA_CLOPE); Q2G160 (NANA_STAA8); P59407 (NANA_LACPL); Q6GK01 (NANA_STAAR): [Recover all] |
Triggered by |
Identifier |
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Protein name |
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Gene name |
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Function | Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate. |
Catalytic activity | RHEA:23296: N-acetylneuraminate = N-acetyl-D-mannosamine + pyruvate
EC 4.1.3.3 |
Pathway | Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate: step 1/5. |
Subunit | Homotetramer. |
Subcellular location | Cytoplasm. |
Similarity | Belongs to the DapA family. NanA subfamily. |
Pfam | PF00701; DHDPS; 1; |
PRINTS | PR00146; DHPICSNTHASE; 1; |
TIGRFAMs | TIGR00683; NanA; 1; |
PROSITE | PS00665; DHDPS_1; 1; |
PS00666; DHDPS_2; 1; |
From: NANA_ECOLI (P0A6L4) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
REGION | 47 | 48 | Substrate binding | S-[TS] | ||||||||
ACT_SITE | 165 | 165 | Schiff-base intermediate with substrate | K | ||||||||
SITE | 137 | 137 | Involved in proton transfer during cleavage | Y |