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Annotation rule MF_01237
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General rule information [?]

Accession MF_01237
Dates 21-MAR-2003 (Created)
19-NOV-2019 (Last updated, Version 31)
Name N_acetylneuram_lyase
Scope
Bacteria
Templates P0A6L4 (NANA_ECOLI); P44539 (NANA_HAEIN); Q9S4K9 (NANA_CLOPE); Q2G160 (NANA_STAA8); P59407 (NANA_LACPL); Q6GK01 (NANA_STAAR): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
NANA
Protein name
RecName: Full=N-acetylneuraminate lyase;
Short=Neu5Ac lyase;
Short=NAL;
EC 4.1.3.3;
AltName: Full=N-acetylneuraminate pyruvate-lyase;
AltName: Full=N-acetylneuraminic acid aldolase;
AltName: Full=Sialate lyase;
AltName: Full=Sialic acid aldolase;
AltName: Full=Sialic acid lyase;
Gene name
nanA

Comments [?]

Function Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate.
Catalytic activity RHEA:23296: N-acetylneuraminate = N-acetyl-D-mannosamine + pyruvate
EC 4.1.3.3
Pathway Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate: step 1/5.
Subunit Homotetramer.
Subcellular location Cytoplasm.
Similarity Belongs to the DapA family. NanA subfamily.

Keywords [?]


Gene Ontology [?]

GO:0008747; Molecular function: N-acetylneuraminate lyase activity.
GO:0005975; Biological process: carbohydrate metabolic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF00701; DHDPS; 1;
PRINTS PR00146; DHPICSNTHASE; 1;
TIGRFAMs TIGR00683; NanA; 1;
PROSITE PS00665; DHDPS_1; 1;
PS00666; DHDPS_2; 1;

Features [?]

From: NANA_ECOLI (P0A6L4)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     47     48       Substrate binding     S-[TS]  
ACT_SITE     165     165       Schiff-base intermediate with substrate     K  
SITE     137     137       Involved in proton transfer during cleavage     Y  

Additional information [?]

Size range 288-305 amino acids
Related rules MF_00418 (DAPA); MF_00694 (KDGD)
Fusion None