HAMAP rule MF_01237
General rule information
[?]
Accession | MF_01237 |
Dates | 21-MAR-2003 (Created) 1-JUN-2023 (Last updated, Version 35) |
Name | N_acetylneuram_lyase |
Scope | Bacteria |
Templates | P0A6L4 (NANA_ECOLI); P44539 (NANA_HAEIN); Q9S4K9 (NANA_CLOPE); Q2G160 (NANA_STAA8); P59407 (NANA_LACPL); Q6GK01 (NANA_STAAR): [Recover all] |
Triggered by |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Identifier |
|
Protein name |
|
Gene name |
|
Comments
[?]
Function | Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate. |
Catalytic activity | RHEA:23296: aceneuramate = N-acetyl-D-mannosamine + pyruvate
EC 4.1.3.3 |
Pathway | Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate: step 1/5. |
Subunit | Homotetramer. |
Subcellular location | Cytoplasm. |
Similarity | Belongs to the DapA family. NanA subfamily. |
Keywords
[?]
Gene Ontology
[?]
GO:0008747; Molecular function: N-acetylneuraminate lyase activity.
GO:0005975; Biological process: carbohydrate metabolic process.
GO:0005737; Cellular component: cytoplasm.
GO:0005975; Biological process: carbohydrate metabolic process.
GO:0005737; Cellular component: cytoplasm.
Cross-references
[?]
Pfam | PF00701; DHDPS; 1; |
PRINTS | PR00146; DHPICSNTHASE; 1; |
NCBIfam | TIGR00683; NanA; 1; |
PROSITE | PS00665; DHDPS_1; 1; |
PS00666; DHDPS_2; 1; |
Features
[?]
From: NANA_ECOLI (P0A6L4) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 47 | 48 | /ligand="substrate | S-[TS] | ||||||||
ACT_SITE | 165 | 165 | Schiff-base intermediate with substrate | K | ||||||||
SITE | 137 | 137 | Involved in proton transfer during cleavage | Y |
Additional information
[?]