HAMAP rule MF_01244

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_01244
Accession	MF_01244
Dates	28-FEB-2005 (Created) 03-SEP-2024 (Last updated, Version 18)
Name	Arch_DHQ_synthase
Scope(s)	Bacteria Aquificia Archaea
Template(s)	Q58646; Q6M1B0; [ Recover all ]
Triggered by	HAMAP; MF_01244 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

case <OC:Archaea>
Identifier	DHQS
Protein name	RecName: Full=3-dehydroquinate synthase; Short=DHQ synthase; EC=1.4.1.24; AltName: Full=3-dehydroquinate synthase II;
Gene name	Name=aroB';
end case
case <OC:Bacteria>
Identifier	DHQSH
Protein name	RecName: Full=3-dehydroquinate synthase homolog; EC=1.4.1.-;
end case

Comments [?]

case <OC:Archaea>
FUNCTION	Catalyzes the oxidative deamination and cyclization of 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.
CATALYTIC ACTIVITY	Reaction=2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + NAD(+) + H2O = 3-dehydroquinate + NH4(+) + NADH + H(+); Xref=Rhea:RHEA:25956, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938, ChEBI:CHEBI:32364, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:58859; EC=1.4.1.24;
end case
SIMILARITY	Belongs to the archaeal-type DHQ synthase family.

Keywords [?]

Gene Ontology [?]

GO:0016639; Molecular function:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

GO:0051287; Molecular function:NAD binding

GO:0009073; Biological process:aromatic amino acid family biosynthetic process

Cross-references [?]

Pfam	PF01959; DHQS; 1;

Features [?]

Additional information [?]