HAMAP rule MF_01244
General rule information
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Accession | MF_01244 |
Dates | 5-JUN-2003 (Created) 19-NOV-2019 (Last updated, Version 20) |
Name | Arch_DHQ_synthase |
Scope | Bacteria; Aquificae
Archaea |
Templates | Q58646 (DHQS_METJA); Q6M1B0 (DHQS_METMP): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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case <OC:Archaea>
Identifier |
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Protein name |
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Gene name |
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end case
case <OC:Bacteria>
Identifier |
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Protein name |
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end case
Comments
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case <OC:Archaea>
Function | Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis. |
Catalytic activity | RHEA:25956: 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+) = 3-dehydroquinate + H(+) + NADH + NH4(+)
EC 1.4.1.24 |
end case
Similarity | Belongs to the archaeal-type DHQ synthase family. |
Keywords
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Gene Ontology
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GO:0016639; Molecular function: oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor.
GO:0051287; Molecular function: NAD binding.
GO:0009073; Biological process: aromatic amino acid family biosynthetic process.
GO:0051287; Molecular function: NAD binding.
GO:0009073; Biological process: aromatic amino acid family biosynthetic process.
Cross-references
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Pfam | PF01959; DHQS; 1; |
Additional information
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Size range | 323-402 amino acids |
Related rules | None |
Fusion | None |