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HAMAP rule MF_01244

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General rule information [?]

Accession MF_01244
Dates 5-JUN-2003 (Created)
19-NOV-2019 (Last updated, Version 20)
Name Arch_DHQ_synthase
Scope(s) Bacteria
Template(s) Q58646 (DHQS_METJA); Q6M1B0 (DHQS_METMP); [ Recover all ]
Triggered by HAMAP; MF_01244 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

case <OC:Archaea>
Identifier DHQS
Protein name RecName: Full=3-dehydroquinate synthase;
                 Short=DHQ synthase;
AltName: Full=3-dehydroquinate synthase II;
Gene name Name=aroB';
end case
case <OC:Bacteria>
Identifier DHQSH
Protein name RecName: Full=3-dehydroquinate synthase homolog;
end case

Comments [?]

case <OC:Archaea>
FUNCTIONCatalyzes the oxidative deamination and cyclization of 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.
CATALYTIC ACTIVITY Reaction=2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+) = 3-dehydroquinate + H(+) + NADH + NH4(+); Xref=Rhea:RHEA:25956, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938, ChEBI:CHEBI:32364, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:58859; EC=;
end case
SIMILARITYBelongs to the archaeal-type DHQ synthase family.

Keywords [?]

Gene Ontology [?]

GO:0016639; Molecular function:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
GO:0051287; Molecular function:NAD binding
GO:0009073; Biological process:aromatic amino acid family biosynthetic process

Cross-references [?]

Pfam PF01959; DHQS; 1;

Features [?]

Additional information [?]

Size range 323-402 amino acids
Related rules None
Fusion Nter: None Cter: None

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