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HAMAP rule MF_01244

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General rule information [?]

Accession MF_01244
Dates 5-JUN-2003 (Created)
19-NOV-2019 (Last updated, Version 20)
Name Arch_DHQ_synthase
Scope
Bacteria; Aquificae
Archaea
Templates Q58646 (DHQS_METJA); Q6M1B0 (DHQS_METMP): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

case <OC:Archaea>
Identifier
DHQS
Protein name
RecName: Full=3-dehydroquinate synthase;
Short=DHQ synthase;
EC 1.4.1.24;
AltName: Full=3-dehydroquinate synthase II;
Gene name
aroB'
end case
case <OC:Bacteria>
Identifier
DHQSH
Protein name
RecName: Full=3-dehydroquinate synthase homolog;
EC 1.4.1.-;
end case

Comments [?]

case <OC:Archaea>
Function Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.
Catalytic activity RHEA:25956: 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+) = 3-dehydroquinate + H(+) + NADH + NH4(+)
EC 1.4.1.24
end case
Similarity Belongs to the archaeal-type DHQ synthase family.

Keywords [?]

Amino-acid biosynthesis
Aromatic amino acid biosynthesis
NAD
Oxidoreductase

Gene Ontology [?]

GO:0016639; Molecular function: oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor.
GO:0051287; Molecular function: NAD binding.
GO:0009073; Biological process: aromatic amino acid family biosynthetic process.

Cross-references [?]

Pfam PF01959; DHQS; 1;

Additional information [?]

Size range 323-402 amino acids
Related rules None
Fusion None


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