HAMAP rule MF_01244
General rule information
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Accession | MF_01244 |
Dates | 5-JUN-2003 (Created)
19-NOV-2019 (Last updated, Version 20) |
Name | Arch_DHQ_synthase |
Scope(s) |
Bacteria Aquificae Archaea |
Template(s) | Q58646 (DHQS_METJA); Q6M1B0 (DHQS_METMP); [ Recover all ] |
Triggered by |
HAMAP; MF_01244 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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case <OC:Archaea> | |
Identifier | DHQS |
Protein name | RecName: Full=3-dehydroquinate synthase; Short=DHQ synthase; EC=1.4.1.24; AltName: Full=3-dehydroquinate synthase II; |
Gene name | Name=aroB'; |
end case | |
case <OC:Bacteria> | |
Identifier | DHQSH |
Protein name | RecName: Full=3-dehydroquinate synthase homolog; EC=1.4.1.-; |
end case |
Comments
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case <OC:Archaea> | |
FUNCTION | Catalyzes the oxidative deamination and cyclization of 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis. |
CATALYTIC ACTIVITY | Reaction=2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+) = 3-dehydroquinate + H(+) + NADH + NH4(+); Xref=Rhea:RHEA:25956, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938, ChEBI:CHEBI:32364, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:58859; EC=1.4.1.24; |
end case | |
SIMILARITY | Belongs to the archaeal-type DHQ synthase family. |
Keywords
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Gene Ontology
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GO:0016639; Molecular function:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor |
GO:0051287; Molecular function:NAD binding |
GO:0009073; Biological process:aromatic amino acid family biosynthetic process |
Cross-references
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Pfam | PF01959; DHQS; 1; |
Features
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Additional information
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Size range | 323-402 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |