HAMAP rule MF_01247
General rule information
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Accession | MF_01247 |
Dates | 6-APR-2004 (Created) 19-NOV-2022 (Last updated, Version 25) |
Name | HTH_type_MalT |
Scope | Bacteria; Gammaproteobacteria |
Template | P06993 (MALT_ECOLI) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides. Specifically binds to the promoter region of its target genes, recognizing a short DNA motif called the MalT box. |
Activity regulation | Activated by ATP and maltotriose, which are both required for DNA binding. |
Subunit | Monomer in solution. Oligomerizes to an active state in the presence of the positive effectors ATP and maltotriose. |
Similarity | Belongs to the MalT family. |
Keywords
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DNA-binding
Transcription
Transcription regulation
Activator
ATP-binding
Nucleotide-binding
Carbohydrate metabolism
Transcription
Transcription regulation
Activator
ATP-binding
Nucleotide-binding
Carbohydrate metabolism
Gene Ontology
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GO:0005524; Molecular function: ATP binding.
GO:0003700; Molecular function: DNA-binding transcription factor activity.
GO:0045913; Biological process: positive regulation of carbohydrate metabolic process.
GO:0045893; Biological process: positive regulation of DNA-templated transcription.
GO:0003700; Molecular function: DNA-binding transcription factor activity.
GO:0045913; Biological process: positive regulation of carbohydrate metabolic process.
GO:0045893; Biological process: positive regulation of DNA-templated transcription.
Cross-references
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Pfam | PF00196; GerE; 1; |
PRINTS | PR00038; HTHLUXR; 1; |
PROSITE | PS00622; HTH_LUXR_1; 1; |
PS50043; HTH_LUXR_2; 1; trigger=PRU00411; |
Features
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From: MALT_ECOLI (P06993) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 39 | 46 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | x-P-[AS]-G-[YF]-G-K-[TS] |
Additional information
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Size range | 870-940 amino acids |
Related rules | None |
Fusion | None |