HAMAP rule MF_01250
General rule information
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| Accession | MF_01250 |
| Dates | 3-AUG-2004 (Created) 27-JUN-2022 (Last updated, Version 14) |
| Name | Pyrophosphat_PpaX |
| Scope | Bacteria; Bacillales
Bacteria; Clostridia |
| Template | Q9JMQ2 (PPAX_BACSU) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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case <OC:Bacillales>
| Protein name |
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end case
case not <OC:Bacillales>
| Protein name |
|
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end case
| Gene name |
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Comments
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case <OC:Bacillales>
| Function | Hydrolyzes pyrophosphate formed during P-Ser-HPr dephosphorylation by HPrK/P. Might play a role in controlling the intracellular pyrophosphate pool. |
end case
| Catalytic activity | RHEA:24576: diphosphate + H2O = H(+) + 2 phosphate
EC 3.6.1.1 |
| Cofactor | Mg(2+) |
| Similarity | Belongs to the HAD-like hydrolase superfamily. PpaX family. |
Keywords
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Gene Ontology
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GO:0000287; Molecular function: magnesium ion binding.
GO:0004427; Molecular function: inorganic diphosphate phosphatase activity.
GO:0004427; Molecular function: inorganic diphosphate phosphatase activity.
Cross-references
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| Pfam | PF00702; Hydrolase; 1; |
| PRINTS | PR00413; HADHALOGNASE; 1; |
| TIGRFAMs | TIGR01549; HAD-SF-IA-v1; 1; |
| TIGR01509; HAD-SF-IA-v3; 1; | |
| TIGR02009; PGMB-YQAB-SF; 1; |
Features
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| From: PPAX_BACSU (Q9JMQ2) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 12 | 12 | Nucleophile | D | ||||||||
Additional information
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| Size range | 214-220 amino acids |
| Related rules | None |
| Fusion | None |
| Comments | In Bacillales, the gene corresponding to this protein is located in the proximity of hprK gene which encodes HPr kinase/phosphorylase. |