HAMAP rule MF_01250
General rule information
[?]
Accession | MF_01250 |
Dates | 3-AUG-2004 (Created)
1-JUN-2023 (Last updated, Version 15) |
Name | Pyrophosphat_PpaX |
Scope(s) |
Bacteria Bacillales Clostridia |
Template(s) | Q9JMQ2 (PPAX_BACSU); [ Recover all ] |
Triggered by |
HAMAP; MF_01250 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Identifier | PPAX |
case <OC:Bacillales> | |
Protein name | RecName: Full=Pyrophosphatase PpaX; EC=3.6.1.1; |
end case | |
case not <OC:Bacillales> | |
Protein name | RecName: Full=Putative pyrophosphatase PpaX; EC=3.6.1.1; |
end case | |
Gene name | Name=ppaX; |
Comments
[?]
case <OC:Bacillales> | |
FUNCTION | Hydrolyzes pyrophosphate formed during P-Ser-HPr dephosphorylation by HPrK/P. Might play a role in controlling the intracellular pyrophosphate pool. |
end case | |
CATALYTIC ACTIVITY | Reaction=diphosphate + H2O = H(+) + 2 phosphate; Xref=Rhea:RHEA:24576, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:43474; EC=3.6.1.1; |
COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; |
SIMILARITY | Belongs to the HAD-like hydrolase superfamily. PpaX family. |
Keywords
[?]
Gene Ontology
[?]
GO:0000287; Molecular function:magnesium ion binding |
GO:0004427; Molecular function:inorganic diphosphate phosphatase activity |
Cross-references
[?]
Pfam | PF00702; Hydrolase; 1; |
PRINTS | PR00413; HADHALOGNASE; 1; |
NCBIfam | TIGR01549; HAD-SF-IA-v1; 1; |
NCBIfam | TIGR01509; HAD-SF-IA-v3; 1; |
NCBIfam | TIGR02009; PGMB-YQAB-SF; 1; |
Features
[?]
From: PPAX_BACSU (Q9JMQ2) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 12 | 12 | /note="Nucleophile" | D |
Additional information
[?]
Size range | 214-220 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |
Comments | In Bacillales, the gene corresponding to this protein is located in the proximity of hprK gene which encodes HPr kinase/phosphorylase. |