HAMAP rule MF_01250

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_01250
Accession	MF_01250
Dates	28-FEB-2005 (Created) 03-SEP-2024 (Last updated, Version 17)
Name	Pyrophosphat_PpaX
Scope(s)	Bacteria Bacillales Clostridia
Template(s)	Q9JMQ2; [ Recover all ]
Triggered by	HAMAP; MF_01250 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	PPAX
case <OC:Bacillales>
Protein name	RecName: Full=Pyrophosphatase PpaX; EC=3.6.1.1;
end case
case not <OC:Bacillales>
Protein name	RecName: Full=Putative pyrophosphatase PpaX; EC=3.6.1.1;
end case
Gene name	Name=ppaX;

Comments [?]

case <OC:Bacillales>
FUNCTION	Hydrolyzes pyrophosphate formed during P-Ser-HPr dephosphorylation by HPrK/P. Might play a role in controlling the intracellular pyrophosphate pool.
end case
CATALYTIC ACTIVITY	Reaction=diphosphate + H2O = 2 phosphate + H(+); Xref=Rhea:RHEA:24576, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:43474; EC=3.6.1.1;
COFACTOR	Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
SIMILARITY	Belongs to the HAD-like hydrolase superfamily. PpaX family.

Keywords [?]

Gene Ontology [?]

GO:0000287; Molecular function:magnesium ion binding

GO:0004427; Molecular function:inorganic diphosphate phosphatase activity

Cross-references [?]

Features [?]

From: PPAX_BACSU (Q9JMQ2)

Key

From

Description

Tag

Condition

FTGroup

ACT_SITE

/note="Nucleophile"

Additional information [?]

Size range	214-220 amino acids
Related rules	None
Fusion	Nter: None Cter: None
Comments	In Bacillales, the gene corresponding to this protein is located in the proximity of hprK gene which encodes HPr kinase/phosphorylase.