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HAMAP rule MF_01250

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General rule information [?]

Accession MF_01250
Dates 3-AUG-2004 (Created)
1-JUN-2023 (Last updated, Version 15)
Name Pyrophosphat_PpaX
Scope(s) Bacteria
Bacillales
Clostridia
Template(s) Q9JMQ2 (PPAX_BACSU); [ Recover all ]
Triggered by HAMAP; MF_01250 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier PPAX
case <OC:Bacillales>
Protein name RecName: Full=Pyrophosphatase PpaX;
                 EC=3.6.1.1;
end case
case not <OC:Bacillales>
Protein name RecName: Full=Putative pyrophosphatase PpaX;
                 EC=3.6.1.1;
end case
Gene name Name=ppaX;

Comments [?]

case <OC:Bacillales>
FUNCTIONHydrolyzes pyrophosphate formed during P-Ser-HPr dephosphorylation by HPrK/P. Might play a role in controlling the intracellular pyrophosphate pool.
end case
CATALYTIC ACTIVITY Reaction=diphosphate + H2O = H(+) + 2 phosphate; Xref=Rhea:RHEA:24576, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:43474; EC=3.6.1.1;
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
SIMILARITYBelongs to the HAD-like hydrolase superfamily. PpaX family.

Keywords [?]


Gene Ontology [?]

GO:0000287; Molecular function:magnesium ion binding
GO:0004427; Molecular function:inorganic diphosphate phosphatase activity

Cross-references [?]

Pfam PF00702; Hydrolase; 1;
PRINTS PR00413; HADHALOGNASE; 1;
NCBIfam TIGR01549; HAD-SF-IA-v1; 1;
NCBIfam TIGR01509; HAD-SF-IA-v3; 1;
NCBIfam TIGR02009; PGMB-YQAB-SF; 1;

Features [?]

From: PPAX_BACSU (Q9JMQ2)
Key From To Description Tag Condition FTGroup
ACT_SITE 12 12 /note="Nucleophile" D

Additional information [?]

Size range 214-220 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments In Bacillales, the gene corresponding to this protein is located in the proximity of hprK gene which encodes HPr kinase/phosphorylase.



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