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Annotation rule MF_01257
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General rule information [?]

Accession MF_01257
Dates 21-APR-2005 (Created)
31-AUG-2020 (Last updated, Version 16)
Name CofD
Scope
Bacteria; Mycobacterium
Bacteria; Nocardia
Bacteria; Streptomyces
Archaea; Archaeoglobi
Archaea; Halobacteria
Archaea; Methanobacteria
Archaea; Methanococci
Archaea; Methanomicrobia
Archaea; Methanopyri
Templates P9WP81 (FBIA_MYCTU); Q8PVT6 (COFD_METMA); Q58653 (COFD_METJA): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

case <OC:Actinobacteria>
Identifier
FBIA
Protein name
RecName: Full=Phosphoenolpyruvate transferase;
EC 2.7.8.28;
AltName: Full=EPPG:FO PEP transferase;
Gene name
fbiA
else case <OC:Archaea>
Identifier
COFD
Protein name
RecName: Full=2-phospho-L-lactate transferase;
EC 2.7.8.28;
AltName: Full=EPPG:FO PEP transferase;
Gene name
cofD
end case

Comments [?]

case <OC:Actinobacteria>
Function Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP.
Catalytic activity RHEA:27510: 7,8-didemethyl-8-hydroxy-5-deazariboflavin + enolpyruvoyl-2-diphospho-5'-guanosine = dehydro coenzyme F420-0 + GMP + H(+)
EC 2.7.8.28
else case <OC:Archaea>
Function Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.
Catalytic activity RHEA:63444: (2S)-lactyl-2-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin = GMP + H(+) + oxidized coenzyme F420-0
EC 2.7.8.28
end case
Cofactor Mg(2+)
Pathway Cofactor biosynthesis; coenzyme F420 biosynthesis.
Subunit Homodimer.
Similarity Belongs to the CofD family.

Keywords [?]


Gene Ontology [?]

GO:0016773; Molecular function: phosphotransferase activity, alcohol group as acceptor.
GO:0052645; Biological process: F420-0 metabolic process.

Cross-references [?]

Pfam PF01933; UPF0052; 1;
TIGRFAMs TIGR01819; F420_cofD; 1;

Features [?]

From: COFD_METMA (Q8PVT6)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     48     48       7,8-didemethyl-8-hydroxy-5-deazariboflavin     D  
BINDING (Optional)     87     87       7,8-didemethyl-8-hydroxy-5-deazariboflavin; via amide nitrogen     [KR]  

Additional information [?]

Size range 296-337 amino acids
Related rules None
Fusion None
Comments CofD homologs are found in the genomes of all organisms currently known to produce coenzyme F420. These include not only the methanogenic archaea but also nonmethanogenic archaea such as Halobacteria and Archaeoglobus, as well as some eubacteria such as Streptomyces, Mycobacterium, Nocardia, and Thermobifida. The reaction was shown to be different according to the species, but IUBMB has created a single EC number (they consider it is the same enzyme).