HAMAP rule MF_01257

General rule information [?]

Accession	MF_01257
Dates	21-APR-2005 (Created) 1-JUN-2023 (Last updated, Version 20)

Name

CofD

Scope

Bacteria; Mycobacterium

Bacteria; Nocardia

Bacteria; Streptomyces

Archaea; Archaeoglobi

Archaea; Halobacteria

Archaea; Methanobacteria

Archaea; Methanococci

Archaea; Methanomicrobia

Archaea; Methanopyri

Templates

P9WP81 (FBIA_MYCTU); Q8PVT6 (COFD_METMA); Q58653 (COFD_METJA): [Recover all]

Triggered by

HAMAP; MF_01257 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

case <OC:Actinomycetota>

Identifier

FBIA

Protein name

RecName:		Full=Phosphoenolpyruvate transferase;
		EC 2.7.8.28;
AltName:		Full=EPPG:FO PEP transferase;

Gene name

fbiA

else case <OC:Archaea>

Identifier

COFD

Protein name

RecName:		Full=2-phospho-L-lactate transferase;
		EC 2.7.8.28;
AltName:		Full=EPPG:FO PEP transferase;

Gene name

cofD

end case

Comments [?]

case <OC:Actinomycetota>

Function	Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP.
Catalytic activity	RHEA:27510: 7,8-didemethyl-8-hydroxy-5-deazariboflavin + enolpyruvoyl-2-diphospho-5'-guanosine = dehydro coenzyme F420-0 + GMP + H(+) EC 2.7.8.28

else case <OC:Archaea>

Function	Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.
Catalytic activity	RHEA:63444: (2S)-lactyl-2-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin = GMP + H(+) + oxidized coenzyme F420-0 EC 2.7.8.28

end case

Cofactor	Mg(2+)
Pathway	Cofactor biosynthesis; coenzyme F420 biosynthesis.
Subunit	Homodimer.
Similarity	Belongs to the CofD family.

Keywords [?]

Magnesium
Transferase

Gene Ontology [?]

GO:0016773; Molecular function: phosphotransferase activity, alcohol group as acceptor.
GO:0052645; Biological process: F420-0 metabolic process.

Cross-references [?]

Pfam	PF01933; UPF0052; 1;
NCBIfam	TIGR01819; F420_cofD; 1;

Features [?]

From: COFD_METMA (Q8PVT6)

Key From To Description Tag Condition FTGroup

BINDING 48 48 /ligand="7,8-didemethyl-8-hydroxy-5-deazariboflavin" /ligand_id="ChEBI:CHEBI:59904 D

BINDING (Optional) 87 87 /ligand="7,8-didemethyl-8-hydroxy-5-deazariboflavin" /ligand_id="ChEBI:CHEBI:59904 [KR]

Additional information [?]

Size range	296-337 amino acids
Related rules	None
Fusion	None
Comments	CofD homologs are found in the genomes of all organisms currently known to produce coenzyme F420. These include not only the methanogenic archaea but also nonmethanogenic archaea such as Halobacteria and Archaeoglobus, as well as some eubacteria such as Streptomyces, Mycobacterium, Nocardia, and Thermobifida. The reaction was shown to be different according to the species, but IUBMB has created a single EC number (they consider it is the same enzyme).

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