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Annotation rule MF_01271
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General rule information [?]

Accession MF_01271
Dates 8-NOV-2006 (Created)
19-NOV-2019 (Last updated, Version 13)
Name GlcNAc_kinase
Scope
Bacteria; Gammaproteobacteria
Templates P75959 (NAGK_ECOLI); Q8ZPZ9 (NAGK_SALTY): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
NAGK
Protein name
RecName: Full=N-acetyl-D-glucosamine kinase;
EC 2.7.1.59;
AltName: Full=GlcNAc kinase;
Gene name
nagK

Comments [?]

Function Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P.
Catalytic activity RHEA:17417: ATP + N-acetyl-D-glucosamine = ADP + H(+) + N-acetyl-D-glucosamine 6-phosphate
EC 2.7.1.59
Pathway Cell wall biogenesis; peptidoglycan recycling.
Similarity Belongs to the ROK (NagC/XylR) family. NagK subfamily.

Keywords [?]

ATP-binding
Carbohydrate metabolism
Kinase
Nucleotide-binding
Transferase
case <FTGroup:1>
Metal-binding
Zinc
end case

Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
case <FTGroup:1>
GO:0008270; Molecular function: zinc ion binding.
end case
GO:0045127; Molecular function: N-acetylglucosamine kinase activity.
GO:0006044; Biological process: N-acetylglucosamine metabolic process.
GO:0009254; Biological process: peptidoglycan turnover.

Cross-references [?]

PROSITE PS01125; ROK; 1;
Pfam PF00480; ROK; 1;

Features [?]

From: NAGK_ECOLI (P75959)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     4     11       ATP        
NP_BIND     133     140       ATP        
METAL (Optional)     157     157       Zinc     H   1
METAL (Optional)     177     177       Zinc     C   1
METAL (Optional)     179     179       Zinc     C   1
METAL (Optional)     184     184       Zinc     C   1

Additional information [?]

Size range 256-305 amino acids
Related rules None
Fusion None
Comments NagK sequences from YERPE, YERPA and YERPN (but not YERPS) are shorter, due to a probable natural frameshift in the C-terminus; they are not included in alignment.


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