HAMAP rule MF_01271

General rule information [?]

Accession	MF_01271
Dates	8-NOV-2006 (Created) 19-NOV-2022 (Last updated, Version 15)

Name	GlcNAc_kinase

Scope

Bacteria; Gammaproteobacteria

Templates

P75959 (NAGK_ECOLI); Q8ZPZ9 (NAGK_SALTY): [Recover all]

Triggered by

HAMAP; MF_01271 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

NAGK

Protein name

RecName:		Full=N-acetyl-D-glucosamine kinase;
		EC 2.7.1.59;
AltName:		Full=GlcNAc kinase;

Gene name

nagK

Comments [?]

Function	Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P.
Catalytic activity	RHEA:17417: ATP + N-acetyl-D-glucosamine = ADP + H(+) + N-acetyl-D-glucosamine 6-phosphate EC 2.7.1.59
Pathway	Cell wall biogenesis; peptidoglycan recycling.
Similarity	Belongs to the ROK (NagC/XylR) family. NagK subfamily.

Keywords [?]

ATP-binding
Carbohydrate metabolism
Kinase
Nucleotide-binding
Transferase

case <FTGroup:1>

Metal-binding
Zinc

end case

Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.

case <FTGroup:1>

GO:0008270; Molecular function: zinc ion binding.

end case

GO:0045127; Molecular function: N-acetylglucosamine kinase activity.
GO:0006044; Biological process: N-acetylglucosamine metabolic process.
GO:0009254; Biological process: peptidoglycan turnover.

Cross-references [?]

PROSITE	PS01125; ROK; 1;
Pfam	PF00480; ROK; 1;

Features [?]

From: NAGK_ECOLI (P75959)

Key From To Description Tag Condition FTGroup

BINDING 4 11 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616

BINDING 133 140 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616

BINDING (Optional) 157 157 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 H 1

BINDING (Optional) 177 177 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 C 1

BINDING (Optional) 179 179 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 C 1

BINDING (Optional) 184 184 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 C 1

Additional information [?]

Size range	256-305 amino acids
Related rules	None
Fusion	None
Comments	NagK sequences from YERPE, YERPA and YERPN (but not YERPS) are shorter, due to a probable natural frameshift in the C-terminus; they are not included in alignment.

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