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HAMAP rule MF_01271

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General rule information [?]

Accession MF_01271
Dates 8-NOV-2006 (Created)
19-NOV-2022 (Last updated, Version 15)
Name GlcNAc_kinase
Scope(s) Bacteria
Template(s) P75959 (NAGK_ECOLI); Q8ZPZ9 (NAGK_SALTY); [ Recover all ]
Triggered by HAMAP; MF_01271 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier NAGK
Protein name RecName: Full=N-acetyl-D-glucosamine kinase;
AltName: Full=GlcNAc kinase;
Gene name Name=nagK;

Comments [?]

FUNCTIONCatalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P.
CATALYTIC ACTIVITY Reaction=ATP + N-acetyl-D-glucosamine = ADP + H(+) + N-acetyl-D- glucosamine 6-phosphate; Xref=Rhea:RHEA:17417, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57513, ChEBI:CHEBI:456216, ChEBI:CHEBI:506227; EC=;
PATHWAYCell wall biogenesis; peptidoglycan recycling.
SIMILARITYBelongs to the ROK (NagC/XylR) family. NagK subfamily.

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding
case <FTGroup:1>
GO:0008270; Molecular function:zinc ion binding
end case
GO:0045127; Molecular function:N-acetylglucosamine kinase activity
GO:0006044; Biological process:N-acetylglucosamine metabolic process
GO:0009254; Biological process:peptidoglycan turnover

Cross-references [?]

PROSITE PS01125; ROK; 1;
Pfam PF00480; ROK; 1;

Features [?]

From: NAGK_ECOLI (P75959)
Key From To Description Tag Condition FTGroup
BINDING 4 11 /ligand="ATP"
BINDING 133 140 /ligand="ATP"
BINDING 157 157 /ligand="Zn(2+)"
H 1
BINDING 177 177 /ligand="Zn(2+)"
C 1
BINDING 179 179 /ligand="Zn(2+)"
C 1
BINDING 184 184 /ligand="Zn(2+)"
C 1

Additional information [?]

Size range 256-305 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments NagK sequences from YERPE, YERPA and YERPN (but not YERPS) are shorter, due to a probable natural frameshift in the C-terminus; they are not included in alignment.

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