HAMAP rule MF_01271
General rule information
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Accession | MF_01271 |
Dates | 8-NOV-2006 (Created) 19-NOV-2022 (Last updated, Version 15) |
Name | GlcNAc_kinase |
Scope | Bacteria; Gammaproteobacteria |
Templates | P75959 (NAGK_ECOLI); Q8ZPZ9 (NAGK_SALTY): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P. |
Catalytic activity | RHEA:17417: ATP + N-acetyl-D-glucosamine = ADP + H(+) + N-acetyl-D-glucosamine 6-phosphate
EC 2.7.1.59 |
Pathway | Cell wall biogenesis; peptidoglycan recycling. |
Similarity | Belongs to the ROK (NagC/XylR) family. NagK subfamily. |
Keywords
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case <FTGroup:1>
end case
Gene Ontology
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GO:0005524; Molecular function: ATP binding.
case <FTGroup:1>
GO:0008270; Molecular function: zinc ion binding.
end case
GO:0045127; Molecular function: N-acetylglucosamine kinase activity.
GO:0006044; Biological process: N-acetylglucosamine metabolic process.
GO:0009254; Biological process: peptidoglycan turnover.
GO:0006044; Biological process: N-acetylglucosamine metabolic process.
GO:0009254; Biological process: peptidoglycan turnover.
Cross-references
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Features
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From: NAGK_ECOLI (P75959) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 4 | 11 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | |||||||||
BINDING | 133 | 140 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | |||||||||
BINDING (Optional) | 157 | 157 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 | H | 1 | |||||||
BINDING (Optional) | 177 | 177 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 | C | 1 | |||||||
BINDING (Optional) | 179 | 179 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 | C | 1 | |||||||
BINDING (Optional) | 184 | 184 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 | C | 1 |
Additional information
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Size range | 256-305 amino acids |
Related rules | None |
Fusion | None |
Comments | NagK sequences from YERPE, YERPA and YERPN (but not YERPS) are shorter, due to a probable natural frameshift in the C-terminus; they are not included in alignment. |