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HAMAP rule MF_01273

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General rule information [?]

Accession MF_01273
Dates 8-NOV-2006 (Created)
1-JUN-2023 (Last updated, Version 18)
Name Pantothen_kinase_2
Scope(s) Bacteria
Template(s) Q2FWC7 (COAW_STAA8); Q6G7I0 (COAW_STAAS); [ Recover all ]
Triggered by HAMAP; MF_01273 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier COAW
Protein name RecName: Full=Type II pantothenate kinase;
AltName: Full=PanK-II;
AltName: Full=Pantothenic acid kinase;
Gene name Name=coaW;

Comments [?]

FUNCTIONCatalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
CATALYTIC ACTIVITY Reaction=(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+); Xref=Rhea:RHEA:16373, ChEBI:CHEBI:10986, ChEBI:CHEBI:15378, ChEBI:CHEBI:29032, ChEBI:CHEBI:30616, ChEBI:CHEBI:456216; EC=;
PATHWAYCofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)- pantothenate: step 1/5.
SIMILARITYBelongs to the type II pantothenate kinase family.

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding
GO:0004594; Molecular function:pantothenate kinase activity
GO:0015937; Biological process:coenzyme A biosynthetic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF03630; Fumble; 1;
NCBIfam TIGR00555; PanK_eukar; 1;

Features [?]

Key From To Description Tag Condition FTGroup
BINDING 6 13 /ligand="ATP"
BINDING 121 125 /ligand="ATP"
ACT_SITE 70 70 /note="Proton acceptor" E
BINDING 99 99 /ligand="ATP"
BINDING 137 137 /ligand="ATP"
BINDING 225 225 /ligand="ATP"

Additional information [?]

Size range 262-276 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments There are three distinct types of pantothenate kinase, as differenciated by primary sequence analysis and biochemical properties: type I (MF_00215), type II (MF_01273) and type III (MF_01274).

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