HAMAP rule MF_01273
General rule information
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Accession | MF_01273 |
Dates | 8-NOV-2006 (Created) 1-JUN-2023 (Last updated, Version 18) |
Name | Pantothen_kinase_2 |
Scope | Bacteria; Bacillota |
Templates | Q2FWC7 (COAW_STAA8); Q6G7I0 (COAW_STAAS): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. |
Catalytic activity | RHEA:16373: (R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)
EC 2.7.1.33 |
Pathway | Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. |
Subunit | Homodimer. |
Subcellular location | Cytoplasm. |
Similarity | Belongs to the type II pantothenate kinase family. |
Keywords
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Gene Ontology
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GO:0005524; Molecular function: ATP binding.
GO:0004594; Molecular function: pantothenate kinase activity.
GO:0015937; Biological process: coenzyme A biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
GO:0004594; Molecular function: pantothenate kinase activity.
GO:0015937; Biological process: coenzyme A biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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Features
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From: COAW_STAAS (Q6G7I0) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 6 | 13 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | |||||||||
BINDING | 121 | 125 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | |||||||||
ACT_SITE | 70 | 70 | Proton acceptor | E | ||||||||
BINDING | 99 | 99 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | T | ||||||||
BINDING | 137 | 137 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | [YF] | ||||||||
BINDING | 225 | 225 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | S |
Additional information
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Size range | 262-276 amino acids |
Related rules | None |
Fusion | None |
Comments | There are three distinct types of pantothenate kinase, as differenciated by primary sequence analysis and biochemical properties: type I (MF_00215), type II (MF_01273) and type III (MF_01274). |