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HAMAP rule MF_01273

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General rule information [?]

Accession MF_01273
Dates 8-NOV-2006 (Created)
1-JUN-2023 (Last updated, Version 18)
Name Pantothen_kinase_2
Bacteria; Bacillota
Templates Q2FWC7 (COAW_STAA8); Q6G7I0 (COAW_STAAS): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Type II pantothenate kinase;
AltName: Full=PanK-II;
AltName: Full=Pantothenic acid kinase;
Gene name

Comments [?]

Function Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
Catalytic activity RHEA:16373: (R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)
Pathway Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.
Subunit Homodimer.
Subcellular location Cytoplasm.
Similarity Belongs to the type II pantothenate kinase family.

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0004594; Molecular function: pantothenate kinase activity.
GO:0015937; Biological process: coenzyme A biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF03630; Fumble; 1;
NCBIfam TIGR00555; PanK_eukar; 1;

Features [?]

Key     From     To       Description   Tag   Condition   FTGroup
BINDING     6     13       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616        
BINDING     121     125       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616        
ACT_SITE     70     70       Proton acceptor     E  
BINDING     99     99       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     T  
BINDING     137     137       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     [YF]  
BINDING     225     225       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     S  

Additional information [?]

Size range 262-276 amino acids
Related rules None
Fusion None
Comments There are three distinct types of pantothenate kinase, as differenciated by primary sequence analysis and biochemical properties: type I (MF_00215), type II (MF_01273) and type III (MF_01274).