HAMAP rule MF_01273

Accession	MF_01273
Dates	8-NOV-2006 (Created) 13-JAN-2023 (Last updated, Version 17)

Name	Pantothen_kinase_2

Scope

Bacteria; Bacillota

Templates

Q2FWC7 (COAW_STAA8); Q6G7I0 (COAW_STAAS): [Recover all]

Triggered by

HAMAP; MF_01273 (Get profile general information and statistics)

Identifier

COAW

Protein name

RecName: Full=Type II pantothenate kinase; EC 2.7.1.33; AltName: Full=PanK-II; AltName: Full=Pantothenic acid kinase;

Gene name

coaW

Function	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
Catalytic activity	RHEA:16373: (R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+) EC 2.7.1.33
Pathway	Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.
Subunit	Homodimer.
Subcellular location	Cytoplasm.
Similarity	Belongs to the type II pantothenate kinase family.

Cytoplasm
ATP-binding
Coenzyme A biosynthesis
Kinase
Nucleotide-binding
Transferase

GO:0005524; Molecular function: ATP binding.
GO:0004594; Molecular function: pantothenate kinase activity.
GO:0015937; Biological process: coenzyme A biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Pfam	PF03630; Fumble; 1;
TIGRFAMs	TIGR00555; PanK_eukar; 1;

From: COAW_STAAS (Q6G7I0)

Key

From

To

Description

Tag

Condition

FTGroup

BINDING

6

13

/ligand="ATP" /ligand_id="ChEBI:CHEBI:30616

BINDING

121

125

/ligand="ATP" /ligand_id="ChEBI:CHEBI:30616

ACT_SITE

70

70

Proton acceptor

E

BINDING

99

99

/ligand="ATP" /ligand_id="ChEBI:CHEBI:30616

T

BINDING

137

137

/ligand="ATP" /ligand_id="ChEBI:CHEBI:30616

[YF]

BINDING

225

225

/ligand="ATP" /ligand_id="ChEBI:CHEBI:30616

S

Size range	262-276 amino acids
Related rules	None
Fusion	None
Comments	There are three distinct types of pantothenate kinase, as differenciated by primary sequence analysis and biochemical properties: type I (MF_00215), type II (MF_01273) and type III (MF_01274).

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