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Annotation rule MF_01276 |
Accession | MF_01276 |
Dates | 29-NOV-2006 (Created) 21-JAN-2020 (Last updated, Version 17) |
Name | Putres_aminotrans_3 |
Scope | Bacteria; Enterobacterales |
Template | P42588 (PAT_ECOLI) |
Triggered by |
Identifier |
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Protein name |
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Gene name |
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Function | Catalyzes the aminotransferase reaction from putrescine to 2-oxoglutarate, leading to glutamate and 4-aminobutanal, which spontaneously cyclizes to form 1-pyrroline. This is the first step in one of two pathways for putrescine degradation, where putrescine is converted into 4-aminobutanoate (gamma-aminobutyrate or GABA) via 4-aminobutanal. Also functions as a cadaverine transaminase in a a L-lysine degradation pathway to succinate that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate. |
Catalytic activity | RHEA:18217: 2-oxoglutarate + an alkane-alpha,omega-diamine = an omega-aminoaldehyde + L-glutamate
EC 2.6.1.29 PhysiologicalDirection=left-to-right (RHEA:18218) |
RHEA:12268: 2-oxoglutarate + putrescine = 1-pyrroline + H2O + L-glutamate
EC 2.6.1.82 PhysiologicalDirection=left-to-right (RHEA:12269) |
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RHEA:61624: 2-oxoglutarate + cadaverine = 5-aminopentanal + L-glutamate
PhysiologicalDirection=left-to-right (RHEA:61625) |
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Cofactor | pyridoxal 5'-phosphate |
Pathway | Amine and polyamine degradation; putrescine degradation; 4-aminobutanal from putrescine (transaminase route): step 1/1. |
Amino-acid degradation. | |
Subunit | Homodimer. |
Similarity | Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. Putrescine aminotransferase subfamily. |
PROSITE | PS00600; AA_TRANSFER_CLASS_3; 1; |
Pfam | PF00202; Aminotran_3; 1; |
TIGRFAMs | TIGR03372; putres_am_tran; 1; |
PIRSF | PIRSF000521; Transaminase_4ab_Lys_Orn; 1; |
From: PAT_ECOLI (P42588) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
REGION | 150 | 151 | Pyridoxal phosphate binding | G-T | ||||||||
BINDING | 274 | 274 | Pyridoxal phosphate | Q | ||||||||
BINDING | 332 | 332 | Pyridoxal phosphate; shared with dimeric partner | T | ||||||||
MOD_RES | 300 | 300 | N6-(pyridoxal phosphate)lysine | K |
Size range | 459-468 amino acids |
Related rules | None |
Fusion | None |