HAMAP rule MF_01282

General rule information [?]

Accession	MF_01282
Dates	13-NOV-2007 (Created) 26-JAN-2023 (Last updated, Version 20)

Name	VirginiamycinB_lyase

Scope

Bacteria; Actinomycetota

Bacteria; Bacillota

Bacteria; Pseudomonadota

Templates

P17978 (VGB_STAAU); Q7W0D3 (VGB_BORPE); Q9KZX7 (VGB_STRCO): [Recover all]

Triggered by

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

VGB

Protein name

Gene name

vgb

Comments [?]

Function	Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid.
Cofactor	Mg(2+)
Subunit	Monomer.
Similarity	Belongs to the Vgb family.

Keywords [?]

Gene Ontology [?]

GO:0016835; Molecular function: carbon-oxygen lyase activity.
GO:0017001; Biological process: antibiotic catabolic process.

Cross-references [?]

Pfam	PF08450; SGL; 1;
	PF01436; NHL; 1;

Features [?]

From: VGB_STAAU (P17978)

Key From To Description Tag Condition FTGroup

ACT_SITE 270 270 Proton acceptor H

BINDING 268 268 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 E

BINDING 284 284 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 E

BINDING 228 228 /ligand="substrate H

Additional information [?]