HAMAP rule MF_01282
General rule information
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| Accession | MF_01282 |
| Dates | 13-NOV-2007 (Created)
26-JAN-2023 (Last updated, Version 20) |
| Name | VirginiamycinB_lyase |
| Scope(s) |
Bacteria Actinomycetota Bacillota Pseudomonadota |
| Template(s) | P17978 (VGB_STAAU); Q7W0D3 (VGB_BORPE); Q9KZX7 (VGB_STRCO); [ Recover all ] |
| Triggered by |
HAMAP; MF_01282 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | VGB |
| Protein name | RecName: Full=Virginiamycin B lyase; EC=4.2.99.-; AltName: Full=Streptogramin B lyase; |
| Gene name | Name=vgb; |
Comments
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| FUNCTION | Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2- amino-butenoic acid. |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; |
| SUBUNIT | Monomer. |
| SIMILARITY | Belongs to the Vgb family. |
Keywords
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Gene Ontology
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| GO:0016835; Molecular function:carbon-oxygen lyase activity |
| GO:0017001; Biological process:antibiotic catabolic process |
Cross-references
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Features
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| From: VGB_STAAU (P17978) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 270 | 270 | /note="Proton acceptor" | H | ||||||||
| BINDING | 268 | 268 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
E | ||||||||
| BINDING | 284 | 284 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
E | ||||||||
| BINDING | 228 | 228 | /ligand="substrate" | H | ||||||||
Additional information
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| Size range | 279-300 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |