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HAMAP rule MF_01282

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General rule information [?]

Accession MF_01282
Dates 13-NOV-2007 (Created)
26-JAN-2023 (Last updated, Version 20)
Name VirginiamycinB_lyase
Scope(s) Bacteria
Template(s) P17978 (VGB_STAAU); Q7W0D3 (VGB_BORPE); Q9KZX7 (VGB_STRCO); [ Recover all ]
Triggered by HAMAP; MF_01282 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier VGB
Protein name RecName: Full=Virginiamycin B lyase;
AltName: Full=Streptogramin B lyase;
Gene name Name=vgb;

Comments [?]

FUNCTIONInactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2- amino-butenoic acid.
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
SIMILARITYBelongs to the Vgb family.

Keywords [?]

Gene Ontology [?]

GO:0016835; Molecular function:carbon-oxygen lyase activity
GO:0017001; Biological process:antibiotic catabolic process

Cross-references [?]

Pfam PF08450; SGL; 1;
Pfam PF01436; NHL; 1;

Features [?]

From: VGB_STAAU (P17978)
Key From To Description Tag Condition FTGroup
ACT_SITE 270 270 /note="Proton acceptor" H
BINDING 268 268 /ligand="Mg(2+)"
BINDING 284 284 /ligand="Mg(2+)"
BINDING 228 228 /ligand="substrate" H

Additional information [?]

Size range 279-300 amino acids
Related rules None
Fusion Nter: None Cter: None

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