HAMAP logo

HAMAP rule MF_01282

Send feedback

General rule information [?]

Accession MF_01282
Dates 13-NOV-2007 (Created)
26-JAN-2023 (Last updated, Version 20)
Name VirginiamycinB_lyase
Bacteria; Actinomycetota
Bacteria; Bacillota
Bacteria; Pseudomonadota
Templates P17978 (VGB_STAAU); Q7W0D3 (VGB_BORPE); Q9KZX7 (VGB_STRCO): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Virginiamycin B lyase;
EC 4.2.99.-;
AltName: Full=Streptogramin B lyase;
Gene name

Comments [?]

Function Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid.
Cofactor Mg(2+)
Subunit Monomer.
Similarity Belongs to the Vgb family.

Keywords [?]

Gene Ontology [?]

GO:0016835; Molecular function: carbon-oxygen lyase activity.
GO:0017001; Biological process: antibiotic catabolic process.

Cross-references [?]

Pfam PF08450; SGL; 1;
PF01436; NHL; 1;

Features [?]

From: VGB_STAAU (P17978)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     270     270       Proton acceptor     H  
BINDING     268     268       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420     E  
BINDING     284     284       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420     E  
BINDING     228     228       /ligand="substrate     H  

Additional information [?]

Size range 279-300 amino acids
Related rules None
Fusion None