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HAMAP rule MF_01285

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General rule information [?]

Accession MF_01285
Dates 5-FEB-2008 (Created)
19-NOV-2022 (Last updated, Version 20)
Name Riboflavin_kinase
Scope(s) Archaea
Template(s) Q60365 (RIFK_METJA); [ Recover all ]
Triggered by HAMAP; MF_01285 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier RIFK
Protein name RecName: Full=Riboflavin kinase;
AltName: Full=CTP-dependent riboflavin kinase;
AltName: Full=CTP:riboflavin 5'-phosphotransferase;
AltName: Full=Flavokinase;
Gene name Name=ribK;

Comments [?]

FUNCTIONCatalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).
CATALYTIC ACTIVITY Reaction=CTP + riboflavin = CDP + FMN + H(+); Xref=Rhea:RHEA:25021, ChEBI:CHEBI:15378, ChEBI:CHEBI:37563, ChEBI:CHEBI:57986, ChEBI:CHEBI:58069, ChEBI:CHEBI:58210; EC=;
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) ion per subunit.;
PATHWAYCofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (CTP route): step 1/1.
SIMILARITYBelongs to the archaeal riboflavin kinase family.

Keywords [?]

Gene Ontology [?]

GO:0000166; Molecular function:nucleotide binding
GO:0000287; Molecular function:magnesium ion binding
GO:0016301; Molecular function:kinase activity
GO:0016773; Molecular function:phosphotransferase activity, alcohol group as acceptor
GO:0009398; Biological process:FMN biosynthetic process

Cross-references [?]

Pfam PF01982; CTP-dep_RFKase; 1;

Features [?]

From: RIFK_METJA (Q60365)
Key From To Description Tag Condition FTGroup
BINDING 10 15 /ligand="CDP"
BINDING 108 111 /ligand="CDP"
BINDING 39 39 /ligand="Mg(2+)"
BINDING 41 41 /ligand="Mg(2+)"
BINDING 95 95 /ligand="FMN"
BINDING 96 96 /ligand="FMN"
BINDING 103 103 /ligand="FMN"

Additional information [?]

Size range 122-159 amino acids
Related rules None
Fusion Nter: <Unknown> Cter: None
Comments Many family members are N-terminally fused with a putative winged HTH DNA-binding domain, that has not been annotated because of bad score and truncation. Possible wrong start in SULAC. Longer N-terminus in SACS2 and IGNH4.

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