HAMAP rule MF_01285

General rule information [?]

Accession	MF_01285
Dates	5-FEB-2008 (Created) 19-NOV-2022 (Last updated, Version 20)

Name	Riboflavin_kinase

Scope

Archaea

Template

Q60365 (RIFK_METJA)

Triggered by

HAMAP; MF_01285 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

RIFK

Protein name

RecName:		Full=Riboflavin kinase;
		Short=RFK;
		EC 2.7.1.161;
AltName:		Full=CTP-dependent riboflavin kinase;
AltName:		Full=CTP:riboflavin 5'-phosphotransferase;
AltName:		Full=Flavokinase;

Gene name

ribK

Comments [?]

Function	Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).
Catalytic activity	RHEA:25021: CTP + riboflavin = CDP + FMN + H(+) EC 2.7.1.161
Cofactor	Mg(2+) Note: Binds 1 Mg(2+) ion per subunit.
Pathway	Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (CTP route): step 1/1.
Similarity	Belongs to the archaeal riboflavin kinase family.

Keywords [?]

Flavoprotein
FMN
Kinase
Magnesium
Metal-binding
Transferase
Nucleotide-binding

Gene Ontology [?]

GO:0000166; Molecular function: nucleotide binding.
GO:0000287; Molecular function: magnesium ion binding.
GO:0016301; Molecular function: kinase activity.
GO:0016773; Molecular function: phosphotransferase activity, alcohol group as acceptor.
GO:0009398; Biological process: FMN biosynthetic process.

Cross-references [?]

Pfam	PF01982; CTP-dep_RFKase; 1;

Features [?]

From: RIFK_METJA (Q60365)

Key From To Description Tag Condition FTGroup

BINDING 10 15 /ligand="CDP" /ligand_id="ChEBI:CHEBI:58069

BINDING 108 111 /ligand="CDP" /ligand_id="ChEBI:CHEBI:58069

BINDING 39 39 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 T

BINDING 41 41 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 N

BINDING 95 95 /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210 [TS]

BINDING (Optional) 96 96 /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210 Y

BINDING 103 103 /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210 E

Additional information [?]

Size range	122-159 amino acids
Related rules	None
Fusion	Nter: <Unknown>; Cter: None
Comments	Many family members are N-terminally fused with a putative winged HTH DNA-binding domain, that has not been annotated because of bad score and truncation. Possible wrong start in SULAC. Longer N-terminus in SACS2 and IGNH4.

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