HAMAP rule MF_01285
General rule information
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| Accession | MF_01285 |
| Dates | 5-FEB-2008 (Created)
3-SEP-2024 (Last updated, Version 21) |
| Name | Riboflavin_kinase |
| Scope(s) |
Archaea |
| Template(s) | Q60365 (RIFK_METJA); [ Recover all ] |
| Triggered by |
HAMAP; MF_01285 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | RIFK |
| Protein name | RecName: Full=Riboflavin kinase; Short=RFK; EC=2.7.1.161; AltName: Full=CTP-dependent riboflavin kinase; AltName: Full=CTP:riboflavin 5'-phosphotransferase; AltName: Full=Flavokinase; |
| Gene name | Name=ribK; |
Comments
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| FUNCTION | Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN). |
| CATALYTIC ACTIVITY | Reaction=riboflavin + CTP = CDP + FMN + H(+); Xref=Rhea:RHEA:25021, ChEBI:CHEBI:15378, ChEBI:CHEBI:37563, ChEBI:CHEBI:57986, ChEBI:CHEBI:58069, ChEBI:CHEBI:58210; EC=2.7.1.161; |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) ion per subunit.; |
| PATHWAY | Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (CTP route): step 1/1. |
| SIMILARITY | Belongs to the archaeal riboflavin kinase family. |
Keywords
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Gene Ontology
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| GO:0000166; Molecular function:nucleotide binding |
| GO:0000287; Molecular function:magnesium ion binding |
| GO:0016301; Molecular function:kinase activity |
| GO:0016773; Molecular function:phosphotransferase activity, alcohol group as acceptor |
| GO:0009398; Biological process:FMN biosynthetic process |
Cross-references
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| Pfam | PF01982; CTP-dep_RFKase; 1; |
Features
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| From: RIFK_METJA (Q60365) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 10 | 15 | /ligand="CDP" /ligand_id="ChEBI:CHEBI:58069" |
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| BINDING | 108 | 111 | /ligand="CDP" /ligand_id="ChEBI:CHEBI:58069" |
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| BINDING | 39 | 39 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
T | ||||||||
| BINDING | 41 | 41 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
N | ||||||||
| BINDING | 95 | 95 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210" |
[TS] | ||||||||
| BINDING | 96 | 96 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210" |
Y | ||||||||
| BINDING | 103 | 103 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210" |
E | ||||||||
Additional information
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| Size range | 122-159 amino acids |
| Related rules |
None |
| Fusion | Nter: <Unknown> Cter: None |
| Comments | Many family members are N-terminally fused with a putative winged HTH DNA-binding domain, that has not been annotated because of bad score and truncation. Possible wrong start in SULAC. Longer N-terminus in SACS2 and IGNH4. |