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HAMAP rule MF_01286

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General rule information [?]

Accession MF_01286
Dates 19-AUG-2008 (Created)
15-FEB-2024 (Last updated, Version 13)
Name DGGGP_synth
Scope(s) Archaea
Template(s) Q9UWY6 (DGGGP_SACS2); O27170 (DGGGP_METTH); [ Recover all ]
Triggered by HAMAP; MF_01286 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier DGGGP
Protein name RecName: Full=Digeranylgeranylglyceryl phosphate synthase;
                 Short=DGGGP synthase;
AltName: Full=(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase;
AltName: Full=Geranylgeranylglycerol-phosphate geranylgeranyltransferase;

Comments [?]

FUNCTIONPrenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
CATALYTIC ACTIVITY Reaction=(2E,6E,10E)-geranylgeranyl diphosphate + sn-3-O- (geranylgeranyl)glycerol 1-phosphate = 2,3-bis-O-(geranylgeranyl)-sn- glycerol 1-phosphate + diphosphate; Xref=Rhea:RHEA:18109, ChEBI:CHEBI:33019, ChEBI:CHEBI:57677, ChEBI:CHEBI:58756, ChEBI:CHEBI:58837; EC=;
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
PATHWAYMembrane lipid metabolism; glycerophospholipid metabolism.
SUBCELLULAR LOCATIONCell membrane; Multi-pass membrane protein.
SIMILARITYBelongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.

Keywords [?]

Gene Ontology [?]

GO:0000287; Molecular function:magnesium ion binding
GO:0047295; Molecular function:geranylgeranylglycerol-phosphate geranylgeranyltransferase activity
GO:0046474; Biological process:glycerophospholipid biosynthetic process
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam PF01040; UbiA; 1;
General Transmembrane; -; 5-9;

Features [?]

Additional information [?]

Size range 267-303 amino acids
Related rules None
Fusion Nter: None Cter: None

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