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Annotation rule MF_01286
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General rule information [?]

Accession MF_01286
Dates 19-AUG-2008 (Created)
29-MAR-2021 (Last updated, Version 12)
Name DGGGP_synth
Templates Q9UWY6 (DGGGP_SACS2); O27170 (DGGGP_METTH): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Digeranylgeranylglyceryl phosphate synthase;
Short=DGGGP synthase;
AltName: Full=(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase;
AltName: Full=Geranylgeranylglycerol-phosphate geranylgeranyltransferase;

Comments [?]

Function Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
Catalytic activity RHEA:18109: (2E,6E,10E)-geranylgeranyl diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate = 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + diphosphate
Cofactor Mg(2+)
Pathway Membrane lipid metabolism; glycerophospholipid metabolism.
Subcellular location Cell membrane; Multi-pass membrane protein.
Similarity Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.

Keywords [?]

Gene Ontology [?]

GO:0000287; Molecular function: magnesium ion binding.
GO:0047295; Molecular function: geranylgeranylglycerol-phosphate geranylgeranyltransferase activity.
GO:0008654; Biological process: phospholipid biosynthetic process.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam PF01040; UbiA; 1;

Computed features [?]

General Transmembrane; -; 5-9; trigger=yes;

Additional information [?]

Size range 267-303 amino acids
Related rules None
Fusion None