HAMAP rule MF_01286
General rule information
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| Accession | MF_01286 |
| Dates | 19-AUG-2008 (Created)
3-SEP-2024 (Last updated, Version 14) |
| Name | DGGGP_synth |
| Scope(s) |
Archaea |
| Template(s) | Q9UWY6 (DGGGP_SACS2); O27170 (DGGGP_METTH); [ Recover all ] |
| Triggered by |
HAMAP; MF_01286 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | DGGGP |
| Protein name | RecName: Full=Digeranylgeranylglyceryl phosphate synthase; Short=DGGGP synthase; Short=DGGGPS; EC=2.5.1.42; AltName: Full=(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase; AltName: Full=Geranylgeranylglycerol-phosphate geranylgeranyltransferase; |
Comments
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| FUNCTION | Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids. |
| CATALYTIC ACTIVITY | Reaction=sn-3-O-(geranylgeranyl)glycerol 1-phosphate + (2E,6E,10E)- geranylgeranyl diphosphate = 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + diphosphate; Xref=Rhea:RHEA:18109, ChEBI:CHEBI:33019, ChEBI:CHEBI:57677, ChEBI:CHEBI:58756, ChEBI:CHEBI:58837; EC=2.5.1.42; |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; |
| PATHWAY | Membrane lipid metabolism; glycerophospholipid metabolism. |
| SUBCELLULAR LOCATION | Cell membrane; Multi-pass membrane protein. |
| SIMILARITY | Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily. |
Keywords
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| Cell membrane |
| Lipid biosynthesis |
| Lipid metabolism |
| Magnesium |
| Membrane |
| Phospholipid biosynthesis |
| Phospholipid metabolism |
| Transferase |
| Transmembrane |
| Transmembrane helix |
Gene Ontology
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| GO:0000287; Molecular function:magnesium ion binding |
| GO:0047295; Molecular function:geranylgeranylglycerol-phosphate geranylgeranyltransferase activity |
| GO:0046474; Biological process:glycerophospholipid biosynthetic process |
| GO:0005886; Cellular component:plasma membrane |
Cross-references
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| Pfam | PF01040; UbiA; 1; |
| General | Transmembrane; -; 5-9; |
Features
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Additional information
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| Size range | 267-303 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |