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HAMAP rule MF_01289

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General rule information [?]

Accession MF_01289
Dates 19-SEP-2008 (Created)
26-JAN-2023 (Last updated, Version 17)
Name Galacton_dehydrat
Scope(s) Bacteria
Template(s) Q6BF17 (DGOD_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01289 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier DGOD
Protein name RecName: Full=D-galactonate dehydratase;
Gene name Name=dgoD;

Comments [?]

FUNCTIONCatalyzes the dehydration of D-galactonate to 2-keto-3-deoxy- D-galactonate.
CATALYTIC ACTIVITY Reaction=D-galactonate = 2-dehydro-3-deoxy-D-galactonate + H2O; Xref=Rhea:RHEA:18649, ChEBI:CHEBI:12931, ChEBI:CHEBI:15377, ChEBI:CHEBI:57989; EC=;
case <FTGroup:1>
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) ion per subunit.;
end case
PATHWAYCarbohydrate acid metabolism; D-galactonate degradation; D- glyceraldehyde 3-phosphate and pyruvate from D-galactonate: step 1/3.
MISCELLANEOUSReaction proceeds via an anti dehydration.
SIMILARITYBelongs to the mandelate racemase/muconate lactonizing enzyme family. GalD subfamily.

Keywords [?]

case <FTGroup:1>
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0000287; Molecular function:magnesium ion binding
end case
GO:0008869; Molecular function:galactonate dehydratase activity
GO:0034194; Biological process:D-galactonate catabolic process

Cross-references [?]

PROSITE PS00908; MR_MLE_1; 1;
PROSITE PS00909; MR_MLE_2; 1;
Pfam PF01188; MR_MLE; 1;
Pfam PF02746; MR_MLE_N; 1;

Features [?]

Key From To Description Tag Condition FTGroup
ACT_SITE 185 185 /note="Proton donor/acceptor" H
ACT_SITE 285 285 /note="Proton donor/acceptor" H
BINDING 183 183 /ligand="Mg(2+)"
D 1
BINDING 209 209 /ligand="Mg(2+)"
E 1
BINDING 235 235 /ligand="Mg(2+)"
E 1
SITE 258 258 /note="Increases basicity of active site His" D
SITE 310 310 /note="Transition state stabilizer" E

Additional information [?]

Size range 365-385 amino acids
Related rules None
Fusion Nter: None Cter: None

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