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HAMAP rule MF_01289

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General rule information [?]

Accession MF_01289
Dates 19-SEP-2008 (Created)
26-JAN-2023 (Last updated, Version 17)
Name Galacton_dehydrat
Bacteria; Pseudomonadota
Template Q6BF17 (DGOD_ECOLI)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=D-galactonate dehydratase;
Gene name

Comments [?]

Function Catalyzes the dehydration of D-galactonate to 2-keto-3-deoxy-D-galactonate.
Catalytic activity RHEA:18649: D-galactonate = 2-dehydro-3-deoxy-D-galactonate + H2O
case <FTGroup:1>
Cofactor Mg(2+)
Note: Binds 1 Mg(2+) ion per subunit.
end case
Pathway Carbohydrate acid metabolism; D-galactonate degradation; D-glyceraldehyde 3-phosphate and pyruvate from D-galactonate: step 1/3.
Miscellaneous Reaction proceeds via an anti dehydration.
Similarity Belongs to the mandelate racemase/muconate lactonizing enzyme family. GalD subfamily.

Keywords [?]

case <FTGroup:1>
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0000287; Molecular function: magnesium ion binding.
end case
GO:0008869; Molecular function: galactonate dehydratase activity.
GO:0034194; Biological process: D-galactonate catabolic process.

Cross-references [?]

PROSITE PS00908; MR_MLE_1; 1;
PS00909; MR_MLE_2; 1;
Pfam PF01188; MR_MLE; 1;
PF02746; MR_MLE_N; 1;

Features [?]

Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     185     185       Proton donor/acceptor     H  
ACT_SITE     285     285       Proton donor/acceptor     H  
BINDING     183     183       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420     D   1
BINDING     209     209       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420     E   1
BINDING     235     235       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420     E   1
SITE     258     258       Increases basicity of active site His     D  
SITE     310     310       Transition state stabilizer     E  

Additional information [?]

Size range 365-385 amino acids
Related rules None
Fusion None