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| Annotation rule MF_01289 |
General rule information
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| Accession | MF_01289 |
| Dates | 19-SEP-2008 (Created) 19-NOV-2019 (Last updated, Version 14) |
| Name | Galacton_dehydrat |
| Scope | Bacteria; Proteobacteria |
| Template | Q6BF17 (DGOD_ECOLI) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Catalyzes the dehydration of D-galactonate to 2-keto-3-deoxy-D-galactonate. |
| Catalytic activity | RHEA:18649: D-galactonate = 2-dehydro-3-deoxy-D-galactonate + H2O
EC 4.2.1.6 |
case <FTGroup:1>
| Cofactor | Mg(2+) Note: Binds 1 Mg(2+) ion per subunit. |
end case
| Pathway | Carbohydrate acid metabolism; D-galactonate degradation; D-glyceraldehyde 3-phosphate and pyruvate from D-galactonate: step 1/3. |
| Miscellaneous | Reaction proceeds via an anti dehydration. |
| Similarity | Belongs to the mandelate racemase/muconate lactonizing enzyme family. GalD subfamily. |
Keywords
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case <FTGroup:1>
end case
Gene Ontology
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case <FTGroup:1>
GO:0000287; Molecular function: magnesium ion binding.
end case
GO:0008869; Molecular function: galactonate dehydratase activity.
GO:0034194; Biological process: D-galactonate catabolic process.
GO:0034194; Biological process: D-galactonate catabolic process.
Cross-references
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Features
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| From: DGOD_ECOLI (Q6BF17) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 185 | 185 | Proton donor/acceptor | H | ||||||||
| ACT_SITE | 285 | 285 | Proton donor/acceptor | H | ||||||||
| METAL | 183 | 183 | Magnesium | D | 1 | |||||||
| METAL | 209 | 209 | Magnesium | E | 1 | |||||||
| METAL | 235 | 235 | Magnesium | E | 1 | |||||||
| SITE | 258 | 258 | Increases basicity of active site His | D | ||||||||
| SITE | 310 | 310 | Transition state stabilizer | E | ||||||||
Additional information
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| Size range | 365-385 amino acids |
| Related rules | None |
| Fusion | None |