HAMAP rule MF_01289
General rule information
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Accession | MF_01289 |
Dates | 19-SEP-2008 (Created) 26-JAN-2023 (Last updated, Version 17) |
Name | Galacton_dehydrat |
Scope | Bacteria; Pseudomonadota |
Template | Q6BF17 (DGOD_ECOLI) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Catalyzes the dehydration of D-galactonate to 2-keto-3-deoxy-D-galactonate. |
Catalytic activity | RHEA:18649: D-galactonate = 2-dehydro-3-deoxy-D-galactonate + H2O
EC 4.2.1.6 |
case <FTGroup:1>
Cofactor | Mg(2+) Note: Binds 1 Mg(2+) ion per subunit. |
end case
Pathway | Carbohydrate acid metabolism; D-galactonate degradation; D-glyceraldehyde 3-phosphate and pyruvate from D-galactonate: step 1/3. |
Miscellaneous | Reaction proceeds via an anti dehydration. |
Similarity | Belongs to the mandelate racemase/muconate lactonizing enzyme family. GalD subfamily. |
Keywords
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case <FTGroup:1>
end case
Gene Ontology
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case <FTGroup:1>
GO:0000287; Molecular function: magnesium ion binding.
end case
GO:0008869; Molecular function: galactonate dehydratase activity.
GO:0034194; Biological process: D-galactonate catabolic process.
GO:0034194; Biological process: D-galactonate catabolic process.
Cross-references
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Features
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From: DGOD_ECOLI (Q6BF17) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 185 | 185 | Proton donor/acceptor | H | ||||||||
ACT_SITE | 285 | 285 | Proton donor/acceptor | H | ||||||||
BINDING | 183 | 183 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 | D | 1 | |||||||
BINDING | 209 | 209 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 | E | 1 | |||||||
BINDING | 235 | 235 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 | E | 1 | |||||||
SITE | 258 | 258 | Increases basicity of active site His | D | ||||||||
SITE | 310 | 310 | Transition state stabilizer | E |
Additional information
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Size range | 365-385 amino acids |
Related rules | None |
Fusion | None |