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Annotation rule MF_01289
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General rule information [?]

Accession MF_01289
Dates 19-SEP-2008 (Created)
19-NOV-2019 (Last updated, Version 14)
Name Galacton_dehydrat
Scope
Bacteria; Proteobacteria
Template Q6BF17 (DGOD_ECOLI)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
DGOD
Protein name
RecName: Full=D-galactonate dehydratase;
Short=GalD;
EC 4.2.1.6;
Gene name
dgoD

Comments [?]

Function Catalyzes the dehydration of D-galactonate to 2-keto-3-deoxy-D-galactonate.
Catalytic activity RHEA:18649: D-galactonate = 2-dehydro-3-deoxy-D-galactonate + H2O
EC 4.2.1.6
case <FTGroup:1>
Cofactor Mg(2+)
Note: Binds 1 Mg(2+) ion per subunit.
end case
Pathway Carbohydrate acid metabolism; D-galactonate degradation; D-glyceraldehyde 3-phosphate and pyruvate from D-galactonate: step 1/3.
Miscellaneous Reaction proceeds via an anti dehydration.
Similarity Belongs to the mandelate racemase/muconate lactonizing enzyme family. GalD subfamily.

Keywords [?]

case <FTGroup:1>
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0000287; Molecular function: magnesium ion binding.
end case
GO:0008869; Molecular function: galactonate dehydratase activity.
GO:0034194; Biological process: D-galactonate catabolic process.

Cross-references [?]

PROSITE PS00908; MR_MLE_1; 1;
PS00909; MR_MLE_2; 1;
Pfam PF01188; MR_MLE; 1;
PF02746; MR_MLE_N; 1;

Features [?]

From: DGOD_ECOLI (Q6BF17)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     185     185       Proton donor/acceptor     H  
ACT_SITE     285     285       Proton donor/acceptor     H  
METAL     183     183       Magnesium     D   1
METAL     209     209       Magnesium     E   1
METAL     235     235       Magnesium     E   1
SITE     258     258       Increases basicity of active site His     D  
SITE     310     310       Transition state stabilizer     E  

Additional information [?]

Size range 365-385 amino acids
Related rules None
Fusion None