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Annotation rule MF_01290
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General rule information [?]

Accession MF_01290
Dates 3-OCT-2008 (Created)
19-NOV-2019 (Last updated, Version 12)
Name KDR_aldolase
Scope
Bacteria; Enterobacterales
Template P76469 (RHMA_ECOLI)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
RHMA
Protein name
RecName: Full=2-keto-3-deoxy-L-rhamnonate aldolase;
Short=KDR aldolase;
EC 4.1.2.53;
AltName: Full=2-dehydro-3-deoxyrhamnonate aldolase;
Gene name
rhmA

Comments [?]

Function Catalyzes the reversible retro-aldol cleavage of 2-keto-3-deoxy-L-rhamnonate (KDR) to pyruvate and lactaldehyde.
Catalytic activity RHEA:25784: 2-dehydro-3-deoxy-L-rhamnonate = (S)-lactaldehyde + pyruvate
EC 4.1.2.53
case <FTGroup:1>
Cofactor Mg(2+)
Note: Binds 1 Mg(2+) ion per subunit.
end case
Subunit Homohexamer.
Similarity Belongs to the HpcH/HpaI aldolase family. KDR aldolase subfamily.

Keywords [?]

case <FTGroup:1>
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0000287; Molecular function: magnesium ion binding.
end case
GO:0016832; Molecular function: aldehyde-lyase activity.

Cross-references [?]

Pfam PF03328; HpcH_HpaI; 1;

Features [?]

From: RHMA_ECOLI (P76469)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     49     49       Proton acceptor     H  
METAL     153     153       Magnesium     E   1
METAL     179     179       Magnesium     D   1
BINDING     151     151       Substrate     Q  
BINDING     178     178       Substrate; via amide nitrogen     A  
BINDING     179     179       Substrate     D  
SITE     74     74       Transition state stabilizer     R  
SITE     88     88       Increases basicity of active site His     D  

Additional information [?]

Size range 267-267 amino acids
Related rules None
Fusion None