HAMAP rule MF_01290
General rule information
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| Accession | MF_01290 |
| Dates | 3-OCT-2008 (Created) 19-NOV-2022 (Last updated, Version 14) |
| Name | KDR_aldolase |
| Scope | Bacteria; Enterobacterales |
| Template | P76469 (RHMA_ECOLI) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Catalyzes the reversible retro-aldol cleavage of 2-keto-3-deoxy-L-rhamnonate (KDR) to pyruvate and lactaldehyde. |
| Catalytic activity | RHEA:25784: 2-dehydro-3-deoxy-L-rhamnonate = (S)-lactaldehyde + pyruvate
EC 4.1.2.53 |
case <FTGroup:1>
| Cofactor | Mg(2+) Note: Binds 1 Mg(2+) ion per subunit. |
end case
| Subunit | Homohexamer. |
| Similarity | Belongs to the HpcH/HpaI aldolase family. KDR aldolase subfamily. |
Keywords
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case <FTGroup:1>
end case
Gene Ontology
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case <FTGroup:1>
GO:0000287; Molecular function: magnesium ion binding.
end case
GO:0016832; Molecular function: aldehyde-lyase activity.
Cross-references
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| Pfam | PF03328; HpcH_HpaI; 1; |
Features
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| From: RHMA_ECOLI (P76469) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 49 | 49 | Proton acceptor | H | ||||||||
| BINDING | 153 | 153 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 | E | 1 | |||||||
| BINDING | 179 | 179 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 | D | 1 | |||||||
| BINDING | 151 | 151 | /ligand="substrate | Q | ||||||||
| BINDING | 178 | 178 | /ligand="substrate | A | ||||||||
| BINDING | 179 | 179 | /ligand="substrate | D | ||||||||
| SITE | 74 | 74 | Transition state stabilizer | R | ||||||||
| SITE | 88 | 88 | Increases basicity of active site His | D | ||||||||
Additional information
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| Size range | 267-267 amino acids |
| Related rules | None |
| Fusion | None |