HAMAP rule MF_01290
General rule information
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| Accession | MF_01290 |
| Dates | 3-OCT-2008 (Created)
19-NOV-2022 (Last updated, Version 14) |
| Name | KDR_aldolase |
| Scope(s) |
Bacteria Enterobacterales |
| Template(s) | P76469 (RHMA_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01290 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | RHMA |
| Protein name | RecName: Full=2-keto-3-deoxy-L-rhamnonate aldolase; Short=KDR aldolase; EC=4.1.2.53; AltName: Full=2-dehydro-3-deoxyrhamnonate aldolase; |
| Gene name | Name=rhmA; |
Comments
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| FUNCTION | Catalyzes the reversible retro-aldol cleavage of 2-keto-3- deoxy-L-rhamnonate (KDR) to pyruvate and lactaldehyde. |
| CATALYTIC ACTIVITY | Reaction=2-dehydro-3-deoxy-L-rhamnonate = (S)-lactaldehyde + pyruvate; Xref=Rhea:RHEA:25784, ChEBI:CHEBI:15361, ChEBI:CHEBI:18041, ChEBI:CHEBI:58371; EC=4.1.2.53; |
| case <FTGroup:1> | |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) ion per subunit.; |
| end case | |
| SUBUNIT | Homohexamer. |
| SIMILARITY | Belongs to the HpcH/HpaI aldolase family. KDR aldolase subfamily. |
Keywords
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| Lyase | |
| case <FTGroup:1> | |
| Magnesium | |
| Metal-binding | |
| end case | |
Gene Ontology
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| case <FTGroup:1> | |
| GO:0000287; Molecular function:magnesium ion binding | |
| end case | |
| GO:0016832; Molecular function:aldehyde-lyase activity | |
Cross-references
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| Pfam | PF03328; HpcH_HpaI; 1; |
Features
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| From: RHMA_ECOLI (P76469) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 49 | 49 | /note="Proton acceptor" | H | ||||||||
| BINDING | 153 | 153 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
E | 1 | |||||||
| BINDING | 179 | 179 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
D | 1 | |||||||
| BINDING | 151 | 151 | /ligand="substrate" | Q | ||||||||
| BINDING | 178 | 178 | /ligand="substrate" | A | ||||||||
| BINDING | 179 | 179 | /ligand="substrate" | D | ||||||||
| SITE | 74 | 74 | /note="Transition state stabilizer" | R | ||||||||
| SITE | 88 | 88 | /note="Increases basicity of active site His" | D | ||||||||
Additional information
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| Size range | 267-267 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |