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Annotation rule MF_01346
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General rule information [?]

Accession MF_01346
Dates 11-APR-2006 (Created)
19-NOV-2019 (Last updated, Version 46)
Name ATP_synth_alpha_bact
Scope
Bacteria
Plastid
Template P0ABB0 (ATPA_ECOLI)
case <OC:Bacteria> or <OG:Chloroplast>
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
ATPA
case <OC:Bacteria>
Protein name
RecName: Full=ATP synthase subunit alpha;
EC 7.1.2.2;
AltName: Full=ATP synthase F1 sector subunit alpha;
AltName: Full=F-ATPase subunit alpha;
else case <OG:Chloroplast>
Protein name
RecName: Full=ATP synthase subunit alpha, chloroplastic;
EC 7.1.2.2;
AltName: Full=ATP synthase F1 sector subunit alpha;
AltName: Full=F-ATPase subunit alpha;
end case
Gene name
atpA

Comments [?]

Function Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.
Catalytic activity RHEA:57720: ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate
EC 7.1.2.2
case <OG:Chloroplast> or <Property:PHOTOSYN>
Subunit F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has four main subunits: a, b, b' and c.
else
Subunit F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
end case
case <OG:Chloroplast>
Subcellular location Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
else case <OC:Cyanobacteria> and not <OC:Gloeobacter>
Subcellular location Cellular thylakoid membrane; Peripheral membrane protein.
else case <OC:Gloeobacter>
Subcellular location Cell inner membrane; Peripheral membrane protein.
else case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location Cell membrane; Peripheral membrane protein.
else case <Property:Membrane=2>
Subcellular location Cell inner membrane; Peripheral membrane protein.
end case
Similarity Belongs to the ATPase alpha/beta chains family.

Keywords [?]

case <OG:Chloroplast> or <OC:Cyanobacteria> and not <OC:Gloeobacter>
else case <OC:Gloeobacter>
else case not defined <Property:Membrane> or <Property:Membrane=1>
else case <Property:Membrane=2>
end case

Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0046933; Molecular function: proton-transporting ATP synthase activity, rotational mechanism.
GO:0015986; Biological process: ATP synthesis coupled proton transport.
case <OC:Cyanobacteria> and not <OC:Gloeobacter>
GO:0042651; Cellular component: thylakoid membrane.
else case <OG:Chloroplast>
GO:0009535; Cellular component: chloroplast thylakoid membrane.
else
GO:0005886; Cellular component: plasma membrane.
end case

Cross-references [?]

PROSITE PS00152; ATPASE_ALPHA_BETA; 1;
Pfam PF00006; ATP-synt_ab; 1;
PF00306; ATP-synt_ab_C; 1;
PF02874; ATP-synt_ab_N; 1;
TIGRFAMs TIGR00962; AtpA; 1;

Features [?]

From: ATPA_ECOLI (P0ABB0)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     169     176       ATP     G-D-[R,K,S]-[Q,A,K,S,G]-[T,I,C,V]-G-K-[T,S,A]  
SITE     373     373       Required for activity     S  

Additional information [?]

Size range 481-670 amino acids
Related rules None
Fusion Nter: None; Cter: <Unknown>
Comments The second copy in some of the Burkholderia is quite a bit longer. There is a 250 residue fusion of unknown function in UREPA and UREP2.