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| Annotation rule MF_01349 |
General rule information
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| Accession | MF_01349 |
| Dates | 29-MAY-2006 (Created) 19-NOV-2019 (Last updated, Version 18) |
| Name | PanCY |
| Scope | Bacteria; Cyanobacteria |
| Templates | P9WIL5 (PANC_MYCTU); P0A6I0 (KCY_ECOLI): [Recover all] |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. |
| Catalyzes the transfer of a phosphate group from ATP to either CMP or dCMP to form CDP or dCDP and ADP, respectively. | |
| Catalytic activity | RHEA:10912: (R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate + H(+)
EC 6.3.2.1 |
| RHEA:11600: ATP + CMP = ADP + CDP
EC 2.7.4.25 |
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| RHEA:25094: ATP + dCMP = ADP + dCDP
EC 2.7.4.25 |
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| Pathway | Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1. |
| Subcellular location | Cytoplasm. |
| Similarity | In the N-terminal section; belongs to the pantothenate synthetase family. |
| In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily. |
Keywords
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Cytoplasm
ATP-binding
Kinase
Ligase
Multifunctional enzyme
Nucleotide-binding
Pantothenate biosynthesis
Transferase
ATP-binding
Kinase
Ligase
Multifunctional enzyme
Nucleotide-binding
Pantothenate biosynthesis
Transferase
Gene Ontology
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GO:0004592; Molecular function: pantoate-beta-alanine ligase activity.
GO:0005524; Molecular function: ATP binding.
GO:0004127; Molecular function: cytidylate kinase activity.
GO:0006220; Biological process: pyrimidine nucleotide metabolic process.
GO:0015940; Biological process: pantothenate biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
GO:0005524; Molecular function: ATP binding.
GO:0004127; Molecular function: cytidylate kinase activity.
GO:0006220; Biological process: pyrimidine nucleotide metabolic process.
GO:0015940; Biological process: pantothenate biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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| Pfam | PF02224; Cytidylate_kin; 1; |
| PF02569; Pantoate_ligase; 1; | |
| TIGRFAMs | TIGR00017; Cmk; 1; |
| TIGR00018; PanC; 1; | |
| TIGR00125; Cyt_tran_rel; 1; |
Features
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| From: PANCY_SYNY3 (Q55074) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| NP_BIND | 30 | 37 | ATP | M-x(3)-H-x(2)-H | ||||||||
| NP_BIND | 150 | 153 | ATP | G-x(2)-D | ||||||||
| NP_BIND | 187 | 190 | ATP | x(3)-R | ||||||||
| REGION | Nter | 283 | Pantoate--beta-alanine ligase | |||||||||
| REGION | 284 | Cter | Cytidylate kinase | |||||||||
| ACT_SITE | 37 | 37 | Proton donor | H | ||||||||
| BINDING | 61 | 61 | Beta-alanine | Q | ||||||||
| BINDING | 61 | 61 | Pantoate | Q | ||||||||
| BINDING | 156 | 156 | Pantoate | Q | ||||||||
| BINDING (Optional) | 179 | 179 | ATP; via amide nitrogen and carbonyl oxygen | [VLIGA] | ||||||||
Additional information
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| Size range | 480-542 amino acids |
| Related rules | MF_00158 (PANC); MF_00238 (KCY); MF_00239 (KCY) |
| Fusion | None |
| Comments | This fusion protein seems only to exist in Cyanobacteria; in other bacteria the 2 enzymes are encoded by separate genes (panC, MF_00158 and cmk, MF_00238) that are not usually in close proximity. |