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Annotation rule MF_01358
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General rule information [?]

Accession MF_01358
Dates 18-NOV-2008 (Created)
19-NOV-2019 (Last updated, Version 19)
Name NDH1_NuoD
Scope
Bacteria
Plastid
Templates P33599 (NUOCD_ECOLI); P27724 (NDHH_SYNY3): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

case <OG:Chloroplast>
Identifier
NDHH
Protein name
RecName: Full=NAD(P)H-quinone oxidoreductase subunit H, chloroplastic;
EC 7.1.1.-;
AltName: Full=NAD(P)H dehydrogenase, subunit H;
AltName: Full=NADH-plastoquinone oxidoreductase 49 kDa subunit;
AltName: Full=NADH-plastoquinone oxidoreductase subunit H;
Gene name
ndhH
else case <OC:Cyanobacteria>
Identifier
NDHH
Protein name
RecName: Full=NAD(P)H-quinone oxidoreductase subunit H;
EC 7.1.1.-;
AltName: Full=NAD(P)H dehydrogenase, subunit H;
AltName: Full=NADH-plastoquinone oxidoreductase subunit H;
AltName: Full=NDH-1 subunit H;
Short=NDH-H;
Gene name
ndhH
else
Identifier
NUOD
Protein name
RecName: Full=NADH-quinone oxidoreductase subunit D;
EC 7.1.1.-;
AltName: Full=NADH dehydrogenase I subunit D;
AltName: Full=NDH-1 subunit D;
Gene name
nuoD
end case

Comments [?]

case <OG:Chloroplast>
Function NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
else case <OC:Cyanobacteria>
Function NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.
else case <OC:Actinobacteria> or <OC:Bacteroidetes> or <OC:Chlorobi> or <OC:Deinococcus-Thermus> or <OC:Firmicutes>
Function NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
else
Function NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
end case
case <OG:Chloroplast> or <OC:Cyanobacteria>
Catalytic activity RHEA:42608: a plastoquinone + (n+1) H(+)(in) + NADH = a plastoquinol + n H(+)(out) + NAD(+)
RHEA:42612: a plastoquinone + (n+1) H(+)(in) + NADPH = a plastoquinol + n H(+)(out) + NADP(+)
else
Catalytic activity RHEA:57888: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
end case
case <OG:Chloroplast>
Subunit NDH is composed of at least 16 different subunits, 5 of which are encoded in the nucleus.
else case <OC:Cyanobacteria>
Subunit NDH-1 can be composed of about 15 different subunits; different subcomplexes with different compositions have been identified which probably have different functions.
else case <OC:Deinococci>
Subunit NDH-1 is composed of 15 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
else
Subunit NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
end case
case <OG:Chloroplast>
Subcellular location Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.
else case <OC:Cyanobacteria> and not <OC:Gloeobacter>
Subcellular location Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side.
else case <OC:Gloeobacter>
Subcellular location Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
else case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location Cell membrane; Peripheral membrane protein; Cytoplasmic side.
else case <Property:Membrane=2>
Subcellular location Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
end case
Similarity Belongs to the complex I 49 kDa subunit family.

Keywords [?]

NAD
case <OG:Chloroplast> or <OC:Cyanobacteria>
else case not <OC:Actinobacteria> and not <OC:Bacteroidetes> and not <OC:Chlorobi> and not <OC:Deinococcus-Thermus> and not <OC:Firmicutes>
end case
case <OG:Chloroplast> or <OC:Cyanobacteria> and not <OC:Gloeobacter>
else case <OC:Gloeobacter>
else case not defined <Property:Membrane> or <Property:Membrane=1>
else case <Property:Membrane=2>
end case

Gene Ontology [?]

GO:0055114; Biological process: oxidation-reduction process.
case <OG:Chloroplast> or <OC:Cyanobacteria>
GO:0016655; Molecular function: oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor.
GO:0019684; Biological process: photosynthesis, light reaction.
else
GO:0050136; Molecular function: NADH dehydrogenase (quinone) activity.
end case
case <OC:Cyanobacteria> and not <OC:Gloeobacter>
GO:0042651; Cellular component: thylakoid membrane.
else case <OG:Chloroplast>
GO:0009535; Cellular component: chloroplast thylakoid membrane.
else
GO:0005886; Cellular component: plasma membrane.
end case

Cross-references [?]

PROSITE PS00535; COMPLEX1_49K; 1;
Pfam PF00346; Complex1_49kDa; 1;
TIGRFAMs TIGR01962; NuoD; 1;

Additional information [?]

Size range 364-482 amino acids
Related rules MF_01359 (NUOCD supersedes the current rule); MF_01397 (NUOCD supersedes the current rule)
Fusion None
Comments 14 proteins form the NDH-1 complex in most bacteria, there are at least 15 subunits in cyanobacteria and chloroplasts. PARDE and THET8 are annotated with another nomenclature. In some bacteria this protein is fused with nuoD, see families MF_01359 and MF_01397. In many bacteria there are both the individual and fused versions.