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HAMAP rule MF_01359

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General rule information [?]

Accession MF_01359
Dates 18-NOV-2008 (Created)
1-JUN-2023 (Last updated, Version 18)
Name NDH1_NuoCD_1
Scope(s) Bacteria
Template(s) P33599 (NUOCD_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01359 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier NUOCD
Protein name RecName: Full=NADH-quinone oxidoreductase subunit C/D;
AltName: Full=NADH dehydrogenase I subunit C/D;
AltName: Full=NDH-1 subunit C/D;
Gene name Name=nuoC; Synonyms=nuoCD, nuoD;

Comments [?]

FUNCTIONNDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
CATALYTIC ACTIVITY Reaction=a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+); Xref=Rhea:RHEA:57888, ChEBI:CHEBI:15378, ChEBI:CHEBI:24646, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:132124;
SUBUNITNDH-1 is composed of 13 different subunits. Subunits NuoB, CD, E, F, and G constitute the peripheral sector of the complex.
case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATIONCell membrane; Peripheral membrane protein; Cytoplasmic side.
else case <Property:Membrane=2>
SUBCELLULAR LOCATIONCell inner membrane; Peripheral membrane protein; Cytoplasmic side.
end case
SIMILARITYIn the N-terminal section; belongs to the complex I 30 kDa subunit family.
SIMILARITYIn the C-terminal section; belongs to the complex I 49 kDa subunit family.

Keywords [?]

case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
Cell membrane
Multifunctional enzyme
<a href="https://www.uniprot.org/keywords/KW-1278">Translocase</a>

Gene Ontology [?]

GO:0016655; Molecular function:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
GO:0050136; Molecular function:NADH dehydrogenase (quinone) activity
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam PF00329; Complex1_30kDa; 1;
Pfam PF00346; Complex1_49kDa; 1;
NCBIfam TIGR01961; NuoC_fam; 1;
NCBIfam TIGR01962; NuoD; 1;

Features [?]

From: NUOCD_ECOLI (P33599)
Key From To Description Tag Condition FTGroup
REGION Nter 186 /note="NADH dehydrogenase I subunit C"
REGION 210 Cter /note="NADH dehydrogenase I subunit D"

Additional information [?]

Size range 578-608 amino acids
Related rules MF_01357
Fusion Nter: MF_01356 (nuoB) Cter: None
Comments This family is specific for the nuoC-nuoD fusion found in the Alpha-, Beta-, Gamma- and some Deltaproteobacteria. The nuoCD fusion protein found in the Aquificae, Bacteroidetes, some other Delta- and Epsilonproteobacteria is different enough that it seems to be another subfamily (MF_01397). The Geobacter, SYNC1 and SYNFM nuoBCD fusion proteins are also members of this family. The individual families are MF_01357 (nuoC) and MF_01358 (nuoD). In many bacteria there are both the individual and fused versions. 14 proteins form the NDH-1 complex in most bacteria, there are at least 15 subunits in cyanobacteria and chloroplasts. PARDE and THET8 are annotated with another nomenclature.

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