HAMAP rule MF_01359

General rule information [?]

Accession	MF_01359
Dates	18-NOV-2008 (Created) 1-JUN-2023 (Last updated, Version 18)

Name	NDH1_NuoCD_1

Scope

Bacteria; Alphaproteobacteria

Bacteria; Betaproteobacteria

Bacteria; Gammaproteobacteria

Template

P33599 (NUOCD_ECOLI)

Triggered by

HAMAP; MF_01359 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

NUOCD

Protein name

RecName:		Full=NADH-quinone oxidoreductase subunit C/D;
		EC 7.1.1.-;
AltName:		Full=NADH dehydrogenase I subunit C/D;
AltName:		Full=NDH-1 subunit C/D;

Gene name

nuoC, nuoCD, nuoD

Comments [?]

Function	NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic activity	RHEA:57888: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Subunit	NDH-1 is composed of 13 different subunits. Subunits NuoB, CD, E, F, and G constitute the peripheral sector of the complex.

case not defined <Property:Membrane> or <Property:Membrane=1>

Subcellular location

Cell membrane; Peripheral membrane protein; Cytoplasmic side.

else case <Property:Membrane=2>

Subcellular location

Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.

end case

Similarity	In the N-terminal section; belongs to the complex I 30 kDa subunit family.
	In the C-terminal section; belongs to the complex I 49 kDa subunit family.

Keywords [?]

case defined <Property:Membrane> and <Property:Membrane=2>

Cell inner membrane

end case

Cell membrane
Membrane
Multifunctional enzyme
NAD
Quinone
Ubiquinone
Translocase
Transport

Gene Ontology [?]

GO:0016655; Molecular function: oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor.
GO:0050136; Molecular function: NADH dehydrogenase (quinone) activity.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

PROSITE	PS00542; COMPLEX1_30K; 1;
	PS00535; COMPLEX1_49K; 1;
Pfam	PF00329; Complex1_30kDa; 1;
	PF00346; Complex1_49kDa; 1;
NCBIfam	TIGR01961; NuoC_fam; 1;
	TIGR01962; NuoD; 1;

Features [?]

From: NUOCD_ECOLI (P33599)

Key From To Description Tag Condition FTGroup

REGION Nter 186 NADH dehydrogenase I subunit C

REGION 210 Cter NADH dehydrogenase I subunit D

Additional information [?]

Size range	578-608 amino acids
Related rules	MF_01357 (NDHJ); MF_01358 (NDHH); MF_01397 (NUOCD)
Fusion	Nter: MF_01356 (nuoB); Cter: None
Comments	This family is specific for the nuoC-nuoD fusion found in the Alpha-, Beta-, Gamma- and some Deltaproteobacteria. The nuoCD fusion protein found in the Aquificae, Bacteroidetes, some other Delta- and Epsilonproteobacteria is different enough that it seems to be another subfamily (MF_01397). The Geobacter, SYNC1 and SYNFM nuoBCD fusion proteins are also members of this family. The individual families are MF_01357 (nuoC) and MF_01358 (nuoD). In many bacteria there are both the individual and fused versions. 14 proteins form the NDH-1 complex in most bacteria, there are at least 15 subunits in cyanobacteria and chloroplasts. PARDE and THET8 are annotated with another nomenclature.

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