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Annotation rule MF_01374
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General rule information [?]

Accession MF_01374
Dates 9-OCT-2007 (Created)
19-NOV-2019 (Last updated, Version 11)
Name Glyoxalase_2
Scope
Bacteria
Templates P0AC84 (GLO2_ECOLI); Q8ZRM2 (GLO2_SALTY): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
GLO2
Protein name
RecName: Full=Hydroxyacylglutathione hydrolase;
EC 3.1.2.6;
AltName: Full=Glyoxalase II;
Short=Glx II;
Gene name
gloB

Comments [?]

Function Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.
Catalytic activity RHEA:21864: an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H(+)
EC 3.1.2.6
Cofactor Zn(2+)
Note: Binds 2 Zn(2+) ions per subunit.
Pathway Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2.
Subunit Monomer.
Similarity Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

Keywords [?]

Hydrolase
Metal-binding
Zinc

Gene Ontology [?]

GO:0004416; Molecular function: hydroxyacylglutathione hydrolase activity.

Cross-references [?]

Pfam PF16123; HAGH_C; 1;
PF00753; Lactamase_B; 1;
PIRSF PIRSF005457; Glx; 1;
TIGRFAMs TIGR03413; GSH_gloB; 1;

Features [?]

From: GLO2_ECOLI (P0AC84)
Key     From     To       Description   Tag   Condition   FTGroup
METAL     53     53       Zinc 1     H   1
METAL     55     55       Zinc 1     H   1
METAL     57     57       Zinc 2     D   2
METAL     58     58       Zinc 2     H   2
METAL     110     110       Zinc 1     H   1
METAL     127     127       Zinc 1     D   1
METAL     127     127       Zinc 2     D   2
METAL     165     165       Zinc 2     H   2

Additional information [?]

Size range 233-272 amino acids
Related rules None
Fusion None


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