HAMAP logo

HAMAP rule MF_01377

Send feedback

General rule information [?]

Accession MF_01377
Dates 4-JUN-2007 (Created)
19-NOV-2022 (Last updated, Version 22)
Name YegS
Bacteria; Gammaproteobacteria
Templates P76407 (YEGS_ECOLI); Q8ZNP1 (YEGS_SALTY): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella>
Protein name
RecName: Full=Probable lipid kinase YegS;
EC 2.7.1.-;
Gene name
Protein name
RecName: Full=Probable lipid kinase YegS-like;
EC 2.7.1.-;
end case

Comments [?]

Function Probably phosphorylates lipids; the in vivo substrate is unknown.
Cofactor Mg(2+)
Note: Binds 1 Mg(2+) ion per subunit. Ca(2+) may be able to substitute.
Subcellular location Cytoplasm.
Similarity Belongs to the diacylglycerol/lipid kinase family. YegS lipid kinase subfamily.

Keywords [?]

Gene Ontology [?]

GO:0000287; Molecular function: magnesium ion binding.
GO:0001727; Molecular function: lipid kinase activity.
GO:0005524; Molecular function: ATP binding.
GO:0008654; Biological process: phospholipid biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF00781; DAGK_cat; 1;
TIGRFAMs TIGR03702; lip_kinase_YegS; 1;
TIGR00147; TIGR00147; 1;
PROSITE PS50146; DAGK; 1; trigger=PRU00783;

Features [?]

From: YEGS_ECOLI (P76407)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     66     72       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616        
ACT_SITE     271     271       Proton acceptor     E  
BINDING     215     215       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420     [LVKRM]  
BINDING     218     218       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420     D  
BINDING     220     220       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420     L  
BINDING     40     40       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     [TS]  
BINDING     95     95       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     [TS]  

Additional information [?]

Size range 290-340 amino acids
Related rules None
Fusion None