HAMAP rule MF_01377
General rule information
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Accession | MF_01377 |
Dates | 4-JUN-2007 (Created)
1-JUN-2023 (Last updated, Version 23) |
Name | YegS |
Scope(s) |
Bacteria Gammaproteobacteria |
Template(s) | P76407 (YEGS_ECOLI); Q8ZNP1 (YEGS_SALTY); [ Recover all ] |
Triggered by |
HAMAP; MF_01377 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | YEGS |
case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella> | |
Protein name | RecName: Full=Probable lipid kinase YegS; EC=2.7.1.-; |
Gene name | Name=yegS; |
else | |
Protein name | RecName: Full=Probable lipid kinase YegS-like; EC=2.7.1.-; |
end case |
Comments
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FUNCTION | Probably phosphorylates lipids; the in vivo substrate is unknown. |
COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 1 Mg(2+) ion per subunit. Ca(2+) may be able to substitute.; |
SUBCELLULAR LOCATION | Cytoplasm. |
SIMILARITY | Belongs to the diacylglycerol/lipid kinase family. YegS lipid kinase subfamily. |
Keywords
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ATP-binding |
Cytoplasm |
Kinase |
Lipid biosynthesis |
Lipid metabolism |
Magnesium |
Metal-binding |
Nucleotide-binding |
Phospholipid biosynthesis |
Phospholipid metabolism |
Transferase |
Gene Ontology
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GO:0000287; Molecular function:magnesium ion binding |
GO:0001727; Molecular function:lipid kinase activity |
GO:0005524; Molecular function:ATP binding |
GO:0008654; Biological process:phospholipid biosynthetic process |
GO:0005737; Cellular component:cytoplasm |
Cross-references
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Pfam | PF00781; DAGK_cat; 1; |
NCBIfam | TIGR03702; lip_kinase_YegS; 1; |
NCBIfam | TIGR00147; TIGR00147; 1; |
PROSITE | PS50146; DAGK; 1; |
Features
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From: YEGS_ECOLI (P76407) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 66 | 72 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
|||||||||
ACT_SITE | 271 | 271 | /note="Proton acceptor" | E | ||||||||
BINDING | 215 | 215 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
[LVKRM] | ||||||||
BINDING | 218 | 218 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
D | ||||||||
BINDING | 220 | 220 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
L | ||||||||
BINDING | 40 | 40 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
[TS] | ||||||||
BINDING | 95 | 95 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
[TS] |
Additional information
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Size range | 290-340 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |