HAMAP rule MF_01377
General rule information
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| Accession | MF_01377 |
| Dates | 4-JUN-2007 (Created) 19-NOV-2022 (Last updated, Version 22) |
| Name | YegS |
| Scope | Bacteria; Gammaproteobacteria |
| Templates | P76407 (YEGS_ECOLI); Q8ZNP1 (YEGS_SALTY): [Recover all] |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella>
| Protein name |
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| Gene name |
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else
| Protein name |
|
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end case
Comments
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| Function | Probably phosphorylates lipids; the in vivo substrate is unknown. |
| Cofactor | Mg(2+) Ca(2+) Note: Binds 1 Mg(2+) ion per subunit. Ca(2+) may be able to substitute. |
| Subcellular location | Cytoplasm. |
| Similarity | Belongs to the diacylglycerol/lipid kinase family. YegS lipid kinase subfamily. |
Keywords
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ATP-binding
Cytoplasm
Kinase
Lipid biosynthesis
Lipid metabolism
Magnesium
Metal-binding
Nucleotide-binding
Phospholipid biosynthesis
Phospholipid metabolism
Transferase
Cytoplasm
Kinase
Lipid biosynthesis
Lipid metabolism
Magnesium
Metal-binding
Nucleotide-binding
Phospholipid biosynthesis
Phospholipid metabolism
Transferase
Gene Ontology
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GO:0000287; Molecular function: magnesium ion binding.
GO:0001727; Molecular function: lipid kinase activity.
GO:0005524; Molecular function: ATP binding.
GO:0008654; Biological process: phospholipid biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
GO:0001727; Molecular function: lipid kinase activity.
GO:0005524; Molecular function: ATP binding.
GO:0008654; Biological process: phospholipid biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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| Pfam | PF00781; DAGK_cat; 1; |
| TIGRFAMs | TIGR03702; lip_kinase_YegS; 1; |
| TIGR00147; TIGR00147; 1; | |
| PROSITE | PS50146; DAGK; 1; trigger=PRU00783; |
Features
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| From: YEGS_ECOLI (P76407) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 66 | 72 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | |||||||||
| ACT_SITE | 271 | 271 | Proton acceptor | E | ||||||||
| BINDING | 215 | 215 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 | [LVKRM] | ||||||||
| BINDING | 218 | 218 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 | D | ||||||||
| BINDING | 220 | 220 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 | L | ||||||||
| BINDING | 40 | 40 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | [TS] | ||||||||
| BINDING | 95 | 95 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | [TS] | ||||||||
Additional information
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| Size range | 290-340 amino acids |
| Related rules | None |
| Fusion | None |