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Annotation rule MF_01382
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General rule information [?]

Accession MF_01382
Dates 14-JAN-2008 (Created)
24-SEP-2019 (Last updated, Version 27)
Name SecA
Scope
Bacteria
Plastid
Templates P10408 (SECA_ECOLI); P28366 (SECA_BACSU); P43803 (SECA_HAEIN): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
SECA
Protein name
RecName: Full=Protein translocase subunit SecA;
Gene name
secA

Comments [?]

case <OG:Chloroplast>
Function Has a central role in coupling the hydrolysis of ATP to the transfer of proteins across the thylakoid membrane.
else case <OC:Alphaproteobacteria> or <OC:Betaproteobacteria> or <OC:Gammaproteobacteria>
Function Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
else
Function Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
end case
case <OC:Cyanobacteria> and not <OC:Gloeobacter>
Function Probably participates in protein translocation into and across both the cytoplasmic and thylakoid membranes in cyanobacterial cells.
end case
case <OC:Proteobacteria>
Subunit Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
else case not <OG:Chloroplast>
Subunit Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
end case
case <FTGroup:1>
Cofactor Zn(2+)
Note: May bind 1 zinc ion per subunit.
end case
case <OG:Chloroplast>
Subcellular location Plastid, chloroplast stroma. Plastid, chloroplast thylakoid membrane; Peripheral membrane protein. Note=A minor fraction is associated with the chloroplast thylakoid membrane.
else case <OC:Cyanobacteria> and not <OC:Gloeobacter>
Subcellular location Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm.
else case <OC:Gloeobacter>
Subcellular location Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50-50.
else case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50-50.
else case <Property:Membrane=2>
Subcellular location Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50-50.
end case
case <OC:Enterobacterales>
Induction Repressed under conditions of excess protein secretion capacity and derepressed when protein secretion becomes limiting. This is regulated by SecM.
end case
Similarity Belongs to the SecA family.

Keywords [?]

case not <OG:Chloroplast>
end case
case <OG:Chloroplast> or <OC:Cyanobacteria> and not <OC:Gloeobacter>
else case <OC:Gloeobacter>
else case not defined <Property:Membrane> or <Property:Membrane=1>
else case <Property:Membrane=2>
end case
case <FTGroup:1>
end case

Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0065002; Biological process: intracellular protein transmembrane transport.
GO:0006605; Biological process: protein targeting.
case <OG:Chloroplast>
GO:0009570; Cellular component: chloroplast stroma.
GO:0009535; Cellular component: chloroplast thylakoid membrane.
else
GO:0005886; Cellular component: plasma membrane.
end case
case <OC:Cyanobacteria> and not <OC:Gloeobacter>
GO:0042651; Cellular component: thylakoid membrane.
end case

Cross-references [?]

PROSITE PS01312; SECA; 1;
PS51196; SECA_MOTOR_DEAD; 1;
Pfam PF07517; SecA_DEAD; 1;
PF01043; SecA_PP_bind; 1;
PF07516; SecA_SW; 1;
PF02810; SEC-C; 1;
PRINTS PR00906; SECA; 1;
TIGRFAMs TIGR00963; SecA; 1;

Features [?]

From: SECA_ECOLI (P10408)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     102     109       ATP     M-[RKQNDAMFPHGSY]-T-G-E-G-K-[TS]  
METAL (Optional)     885     885       Zinc     C   1
METAL (Optional)     887     887       Zinc     C   1
METAL (Optional)     896     896       Zinc     C   1
METAL (Optional)     897     897       Zinc     [CH]   1

Additional information [?]

Size range 649-1160 amino acids
Related rules None
Fusion Nter: None; Cter: <Unknown>
Comments It is not yet clear whether the form that inserts preproteins into the membrane in conjunction with SecYEG is monmeric or dimeric. In some bacteria that have 2 copies (Listeria, Mycobacteria), 1 copy (secA1) is thought to be essential whereas the other (secA2) is required only for translocation of a subset of proteins. Mycobacteria have 2 copies, with the exception of MYCA1 which only has a copy of secA2. MYCPE has a C- terminal extension that resembles nothing in the database. SECA1_RHOBA (AC Q7UDY6) has a few short inserts compared to other sequences; its length has not been taken into account in the size range. In BAUCH (BCI_0515) it is annotated as a pseudogene with a verfied point mutation leading to a slightly truncated protein. Not encoded in CARRP.