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Annotation rule MF_01384
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General rule information [?]

Accession MF_01384
Dates 8-MAY-2008 (Created)
19-NOV-2019 (Last updated, Version 12)
Name UreD
Scope
Bacteria; Actinobacteria
Bacteria; Bacteroidetes
Bacteria; Chloroflexi
Bacteria; Cyanobacteria
Bacteria; Deinococcus-Thermus
Bacteria; Firmicutes
Bacteria; Magnetococcus
Bacteria; Proteobacteria
Bacteria; Tenericutes
Bacteria; Verrucomicrobia
Archaea
Templates Q09063 (URED_KLEAE); P17089 (URED_PROMH); Q9ZFR5 (URED_YERPE): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

case not <OC:Helicobacter>
Identifier
URED
Protein name
RecName: Full=Urease accessory protein UreD;
Gene name
ureD
else case <OC:Helicobacter>
Identifier
UREH
Protein name
RecName: Full=Urease accessory protein UreH;
Gene name
ureH
end case

Comments [?]

Function Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
case not <OC:Helicobacter>
Subunit UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.
else case <OC:Helicobacter>
Subunit UreH, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.
end case
Subcellular location Cytoplasm.
Similarity Belongs to the UreD family.

Keywords [?]

Chaperone
Cytoplasm
Nickel insertion

Gene Ontology [?]

GO:0016151; Molecular function: nickel cation binding.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF01774; UreD; 1;

Additional information [?]

Size range 240-329 amino acids
Related rules None
Fusion None
Comments Called ureH in Helicobacter where ureD is an unrelated protein of the urease operon. Some E.coli EHEC strains are urease negative despite the presence of the operon in their genomes; in a few cases this has been shown to be due to nonsense mutations in ureD, for example ECO57. YERPE has a different nonsense mutation and is also non-functional. For some orally acquired pathogens (Brucella, Helicobacter, YERPE) urease acts as a virulence factor. In Brucella there are usually 2 urease operons.


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