HAMAP rule MF_01384
General rule information
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Accession | MF_01384 |
Dates | 8-MAY-2008 (Created) 17-FEB-2023 (Last updated, Version 17) |
Name | UreD |
Scope | Bacteria; Actinomycetota
Bacteria; Bacteroidota
Bacteria; Chloroflexota
Bacteria; Cyanobacteriota
Bacteria; Deinococcota
Bacteria; Bacillota
Bacteria; Magnetococcus
Bacteria; Pseudomonadota
Bacteria; Mycoplasmatota
Bacteria; Verrucomicrobiota
Archaea |
Templates | Q09063 (URED_KLEAE); P17089 (URED_PROMH); Q9ZFR5 (URED_YERPE): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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case not <OC:Helicobacter>
Identifier |
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Protein name |
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Gene name |
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else case <OC:Helicobacter>
Identifier |
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Protein name |
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Gene name |
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end case
Comments
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Function | Required for maturation of urease via the functional incorporation of the urease nickel metallocenter. |
case not <OC:Helicobacter>
Subunit | UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel. |
else case <OC:Helicobacter>
Subunit | UreH, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel. |
end case
Subcellular location | Cytoplasm. |
Similarity | Belongs to the UreD family. |
Keywords
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Gene Ontology
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Cross-references
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Pfam | PF01774; UreD; 1; |
Additional information
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Size range | 240-329 amino acids |
Related rules | None |
Fusion | None |
Comments | Called ureH in Helicobacter where ureD is an unrelated protein of the urease operon. Some E.coli EHEC strains are urease negative despite the presence of the operon in their genomes; in a few cases this has been shown to be due to nonsense mutations in ureD, for example ECO57. YERPE has a different nonsense mutation and is also non-functional. For some orally acquired pathogens (Brucella, Helicobacter, YERPE) urease acts as a virulence factor. In Brucella there are usually 2 urease operons. |