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Annotation rule MF_01384 |
General rule information
[?]
Accession |
MF_01384 |
Dates |
8-MAY-2008 (Created) 19-NOV-2019 (Last updated, Version 12) |
Scope |
Bacteria; Actinobacteria
Bacteria; Bacteroidetes
Bacteria; Chloroflexi
Bacteria; Cyanobacteria
Bacteria; Deinococcus-Thermus
Bacteria; Firmicutes
Bacteria; Magnetococcus
Bacteria; Proteobacteria
Bacteria; Tenericutes
Bacteria; Verrucomicrobia
Archaea |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
case not <OC:Helicobacter>
Protein name |
RecName:
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Full=Urease accessory protein UreD;
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else case <OC:Helicobacter>
Protein name |
RecName:
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Full=Urease accessory protein UreH;
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end case
Function |
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter. |
case not <OC:Helicobacter>
Subunit |
UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel. |
else case <OC:Helicobacter>
Subunit |
UreH, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel. |
end case
Subcellular location |
Cytoplasm. |
Similarity |
Belongs to the UreD family. |
Additional information
[?]
Size range |
240-329 amino acids |
Related rules |
None |
Fusion |
None |
Comments |
Called ureH in Helicobacter where ureD is an unrelated protein of the urease operon. Some E.coli EHEC strains are urease negative despite the presence of the operon in their genomes; in a few cases this has been shown to be due to nonsense mutations in ureD, for example ECO57. YERPE has a different nonsense mutation and is also non-functional. For some orally acquired pathogens (Brucella, Helicobacter, YERPE) urease acts as a virulence factor. In Brucella there are usually 2 urease operons. |