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Annotation rule MF_01385
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General rule information [?]

Accession MF_01385
Dates 19-JUN-2008 (Created)
19-NOV-2019 (Last updated, Version 8)
Name UreF
Scope
Bacteria
Templates P18318 (UREF_KLEAE); P17091 (UREF_PROMH); Q09065 (UREF_HELPY): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
UREF
Protein name
RecName: Full=Urease accessory protein UreF;
Gene name
ureF

Comments [?]

Function Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
case not <OC:Helicobacter>
Subunit UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.
else case <OC:Helicobacter>
Subunit UreH, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.
end case
Subcellular location Cytoplasm.
Similarity Belongs to the UreF family.

Keywords [?]


Gene Ontology [?]

GO:0016151; Molecular function: nickel cation binding.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF01730; UreF; 1;

Additional information [?]

Size range 205-266 amino acids
Related rules None
Fusion None
Comments For some orally acquired pathogens (Brucella, YERPE) urease acts as a virulence factor. In Brucella there are usually 2 urease operons.