HAMAP rule MF_01385

General rule information [?]

Accession	MF_01385
Dates	19-JUN-2008 (Created) 20-MAY-2021 (Last updated, Version 9)

Name

UreF

Scope

Bacteria

Templates

P18318 (UREF_KLEAE); P17091 (UREF_PROMH); Q09065 (UREF_HELPY): [Recover all]

Triggered by

HAMAP; MF_01385 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

UREF

Protein name

RecName:

Full=Urease accessory protein UreF;

Gene name

ureF

Comments [?]

Function

Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.

case not <OC:Helicobacter>

Subunit

UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

else case <OC:Helicobacter>

Subunit

UreH, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

end case

Subcellular location	Cytoplasm.
Similarity	Belongs to the UreF family.

Keywords [?]

Chaperone
Cytoplasm
Nickel insertion

Gene Ontology [?]

GO:0016151; Molecular function: nickel cation binding.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam	PF01730; UreF; 1;

Additional information [?]

Size range	205-266 amino acids
Related rules	None
Fusion	None
Comments	For some orally acquired pathogens (Brucella, YERPE) urease acts as a virulence factor. In Brucella there are usually 2 urease operons.

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