HAMAP rule MF_01385
General rule information
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Accession | MF_01385 |
Dates | 19-JUN-2008 (Created)
20-MAY-2021 (Last updated, Version 9) |
Name | UreF |
Scope(s) |
Bacteria |
Template(s) | P18318 (UREF_KLEAE); P17091 (UREF_PROMH); Q09065 (UREF_HELPY); [ Recover all ] |
Triggered by |
HAMAP; MF_01385 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | UREF |
Protein name | RecName: Full=Urease accessory protein UreF; |
Gene name | Name=ureF; |
Comments
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FUNCTION | Required for maturation of urease via the functional incorporation of the urease nickel metallocenter. |
case not <OC:Helicobacter> | |
SUBUNIT | UreD, UreF and UreG form a complex that acts as a GTP- hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel. |
else case <OC:Helicobacter> | |
SUBUNIT | UreH, UreF and UreG form a complex that acts as a GTP- hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel. |
end case | |
SUBCELLULAR LOCATION | Cytoplasm. |
SIMILARITY | Belongs to the UreF family. |
Keywords
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Gene Ontology
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GO:0016151; Molecular function:nickel cation binding |
GO:0005737; Cellular component:cytoplasm |
Cross-references
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Pfam | PF01730; UreF; 1; |
Features
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Additional information
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Size range | 205-266 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |
Comments | For some orally acquired pathogens (Brucella, YERPE) urease acts as a virulence factor. In Brucella there are usually 2 urease operons. |