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HAMAP rule MF_01385

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General rule information [?]

Accession MF_01385
Dates 19-JUN-2008 (Created)
20-MAY-2021 (Last updated, Version 9)
Name UreF
Scope(s) Bacteria
Template(s) P18318 (UREF_KLEAE); P17091 (UREF_PROMH); Q09065 (UREF_HELPY); [ Recover all ]
Triggered by HAMAP; MF_01385 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier UREF
Protein name RecName: Full=Urease accessory protein UreF;
Gene name Name=ureF;

Comments [?]

FUNCTIONRequired for maturation of urease via the functional incorporation of the urease nickel metallocenter.
case not <OC:Helicobacter>
SUBUNITUreD, UreF and UreG form a complex that acts as a GTP- hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.
else case <OC:Helicobacter>
SUBUNITUreH, UreF and UreG form a complex that acts as a GTP- hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.
end case
SUBCELLULAR LOCATIONCytoplasm.
SIMILARITYBelongs to the UreF family.

Keywords [?]


Gene Ontology [?]

GO:0016151; Molecular function:nickel cation binding
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF01730; UreF; 1;

Features [?]


Additional information [?]

Size range 205-266 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments For some orally acquired pathogens (Brucella, YERPE) urease acts as a virulence factor. In Brucella there are usually 2 urease operons.



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