HAMAP rule MF_01385
General rule information
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| Accession | MF_01385 |
| Dates | 19-JUN-2008 (Created)
20-MAY-2021 (Last updated, Version 9) |
| Name | UreF |
| Scope(s) |
Bacteria |
| Template(s) | P18318 (UREF_KLEAE); P17091 (UREF_PROMH); Q09065 (UREF_HELPY); [ Recover all ] |
| Triggered by |
HAMAP; MF_01385 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | UREF |
| Protein name | RecName: Full=Urease accessory protein UreF; |
| Gene name | Name=ureF; |
Comments
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| FUNCTION | Required for maturation of urease via the functional incorporation of the urease nickel metallocenter. |
| case not <OC:Helicobacter> | |
| SUBUNIT | UreD, UreF and UreG form a complex that acts as a GTP- hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel. |
| else case <OC:Helicobacter> | |
| SUBUNIT | UreH, UreF and UreG form a complex that acts as a GTP- hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel. |
| end case | |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the UreF family. |
Keywords
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Gene Ontology
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| GO:0016151; Molecular function:nickel cation binding |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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| Pfam | PF01730; UreF; 1; |
Features
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Additional information
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| Size range | 205-266 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | For some orally acquired pathogens (Brucella, YERPE) urease acts as a virulence factor. In Brucella there are usually 2 urease operons. |