HAMAP rule MF_01397

General rule information [?]

Accession	MF_01397
Dates	29-JAN-2009 (Created) 1-JUN-2023 (Last updated, Version 12)

Name	NDH1_NuoCD_2

Scope

Bacteria; Aquificae

Bacteria; Bacteroidia

Bacteria; Deltaproteobacteria

Bacteria; Campylobacteraceae

Template

P33599 (NUOCD_ECOLI)

Triggered by

HAMAP; MF_01397 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

NUOCD

Protein name

RecName:		Full=NADH-quinone oxidoreductase subunit C/D;
		EC 7.1.1.-;
AltName:		Full=NADH dehydrogenase I subunit C/D;
AltName:		Full=NDH-1 subunit C/D;
AltName:		Full=NUO3/NUO4;

Gene name

nuoC

Comments [?]

Function	NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic activity	RHEA:57888: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Subunit	NDH-1 is composed of 13 different subunits. Subunits NuoB, CD, E, F, and G constitute the peripheral sector of the complex.
Subcellular location	Cell inner membrane; Peripheral membrane protein.
Similarity	In the N-terminal section; belongs to the complex I 30 kDa subunit family.
	In the C-terminal section; belongs to the complex I 49 kDa subunit family.

Keywords [?]

Cell inner membrane
Cell membrane
Cytoplasm
Membrane
Multifunctional enzyme
NAD
Quinone
Translocase
Transport
Ubiquinone

Gene Ontology [?]

GO:0016655; Molecular function: oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor.
GO:0050136; Molecular function: NADH dehydrogenase (quinone) activity.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

PROSITE	PS00542; COMPLEX1_30K; 1;
	PS00535; COMPLEX1_49K; 1;
Pfam	PF00329; Complex1_30kDa; 1;
	PF00346; Complex1_49kDa; 1;
NCBIfam	TIGR01961; NuoC_fam; 1;
	TIGR01962; NuoD; 1;

Features [?]

From: NUOCD_BDEBA (Q6MIR5)

Key From To Description Tag Condition FTGroup

REGION Nter 157 NADH dehydrogenase I subunit C

REGION 175 Cter NADH dehydrogenase I subunit D

Additional information [?]

Size range	519-593 amino acids
Related rules	MF_01357 (NDHJ); MF_01358 (NDHH); MF_01359 (NUOCD)
Fusion	None
Comments	This family is specific for the nuoC-nuoD fusion found in Aquificae, Bacteroidetes, Delta-and Epsilonproteobacteria. The nuoCD fusion protein found in the Alpha-, Beta- and Gammaproteobacteria is different enough that it seems to be another subfamily (MF_01359). The individual families are MF_01357 (nuoC) and MF_01358 (nuoD). In many bacteria there are both the individual and fused versions. 14 proteins form the NDH-1 complex in most bacteria, there are at least 15 subunits in cyanobacteria and chloroplasts. PARDE and THET8 are annotated with another nomenclature.

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