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HAMAP rule MF_01397

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General rule information [?]

Accession MF_01397
Dates 29-JAN-2009 (Created)
1-JUN-2023 (Last updated, Version 12)
Name NDH1_NuoCD_2
Bacteria; Aquificae
Bacteria; Bacteroidia
Bacteria; Deltaproteobacteria
Bacteria; Campylobacteraceae
Template P33599 (NUOCD_ECOLI)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=NADH-quinone oxidoreductase subunit C/D;
EC 7.1.1.-;
AltName: Full=NADH dehydrogenase I subunit C/D;
AltName: Full=NDH-1 subunit C/D;
AltName: Full=NUO3/NUO4;
Gene name

Comments [?]

Function NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic activity RHEA:57888: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Subunit NDH-1 is composed of 13 different subunits. Subunits NuoB, CD, E, F, and G constitute the peripheral sector of the complex.
Subcellular location Cell inner membrane; Peripheral membrane protein.
Similarity In the N-terminal section; belongs to the complex I 30 kDa subunit family.
In the C-terminal section; belongs to the complex I 49 kDa subunit family.

Keywords [?]

Gene Ontology [?]

GO:0016655; Molecular function: oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor.
GO:0050136; Molecular function: NADH dehydrogenase (quinone) activity.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

PS00535; COMPLEX1_49K; 1;
Pfam PF00329; Complex1_30kDa; 1;
PF00346; Complex1_49kDa; 1;
NCBIfam TIGR01961; NuoC_fam; 1;
TIGR01962; NuoD; 1;

Features [?]

Key     From     To       Description   Tag   Condition   FTGroup
REGION     Nter     157       NADH dehydrogenase I subunit C        
REGION     175     Cter       NADH dehydrogenase I subunit D        

Additional information [?]

Size range 519-593 amino acids
Related rules MF_01357 (NDHJ); MF_01358 (NDHH); MF_01359 (NUOCD)
Fusion None
Comments This family is specific for the nuoC-nuoD fusion found in Aquificae, Bacteroidetes, Delta-and Epsilonproteobacteria. The nuoCD fusion protein found in the Alpha-, Beta- and Gammaproteobacteria is different enough that it seems to be another subfamily (MF_01359). The individual families are MF_01357 (nuoC) and MF_01358 (nuoD). In many bacteria there are both the individual and fused versions. 14 proteins form the NDH-1 complex in most bacteria, there are at least 15 subunits in cyanobacteria and chloroplasts. PARDE and THET8 are annotated with another nomenclature.