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HAMAP rule MF_01401

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General rule information [?]

Accession MF_01401
Dates 9-APR-2002 (Created)
1-JUN-2023 (Last updated, Version 30)
Name MsrA
Scope(s) Bacteria
Template(s) P14930 (MSRAB_NEIGO); Q9JWM8 (MSRAB_NEIMA); [ Recover all ]
Triggered by HAMAP; MF_01401 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MSRA
Protein name RecName: Full=Peptide methionine sulfoxide reductase MsrA;
                 Short=Protein-methionine-S-oxide reductase;
AltName: Full=Peptide-methionine (S)-S-oxide reductase;
                 Short=Peptide Met(O) reductase;
Gene name Name=msrA;

Comments [?]

FUNCTIONHas an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
CATALYTIC ACTIVITY Reaction=[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]; Xref=Rhea:RHEA:14217, Rhea:RHEA-COMP:10698, Rhea:RHEA-COMP:10700, Rhea:RHEA-COMP:12313, Rhea:RHEA-COMP:12315, ChEBI:CHEBI:15377, ChEBI:CHEBI:16044, ChEBI:CHEBI:29950, ChEBI:CHEBI:44120, ChEBI:CHEBI:50058; EC=;
CATALYTIC ACTIVITY Reaction=[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]- dithiol + L-methionine (S)-S-oxide; Xref=Rhea:RHEA:19993, Rhea:RHEA- COMP:10698, Rhea:RHEA-COMP:10700, ChEBI:CHEBI:15377, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058, ChEBI:CHEBI:57844, ChEBI:CHEBI:58772; EC=;
SIMILARITYBelongs to the MsrA Met sulfoxide reductase family.

Keywords [?]

Gene Ontology [?]

GO:0008113; Molecular function:peptide-methionine (S)-S-oxide reductase activity
GO:0036211; Biological process:protein modification process

Cross-references [?]

Pfam PF01625; PMSR; 1;
NCBIfam TIGR00401; MsrA; 1;

Features [?]

From: MSRA_ECOLI (P0A744)
Key From To Description Tag Condition FTGroup
ACT_SITE 52 52 C

Additional information [?]

Size range 123-222 amino acids
Related rules None
Fusion Nter: MF_01400 (msrB); <Thioredoxin domain> Cter: MF_01400 (msrB)

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