Home  |  Contact
Annotation rule MF_01401
Send feedback

General rule information [?]

Accession MF_01401
Dates 9-APR-2002 (Created)
19-NOV-2019 (Last updated, Version 28)
Name MsrA
Scope
Bacteria
Archaea
Templates P14930 (MSRAB_NEIGO); Q9JWM8 (MSRAB_NEIMA): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
MSRA
Protein name
RecName: Full=Peptide methionine sulfoxide reductase MsrA;
Short=Protein-methionine-S-oxide reductase;
EC 1.8.4.11;
AltName: Full=Peptide-methionine (S)-S-oxide reductase;
Short=Peptide Met(O) reductase;
Gene name
msrA

Comments [?]

Function Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
Catalytic activity RHEA:14217: [thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]
EC 1.8.4.11
RHEA:19993: [thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide
EC 1.8.4.11
Similarity Belongs to the MsrA Met sulfoxide reductase family.

Keywords [?]


Gene Ontology [?]

GO:0008113; Molecular function: peptide-methionine (S)-S-oxide reductase activity.
GO:0006464; Biological process: cellular protein modification process.

Cross-references [?]

Pfam PF01625; PMSR; 1;
TIGRFAMs TIGR00401; MsrA; 1;

Features [?]

From: MSRA_ECOLI (P0A744)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     52     52             C  

Additional information [?]

Size range 123-222 amino acids
Related rules None
Fusion Nter: MF_01400 (msrB), <Thioredoxin domain>; Cter: MF_01400 (msrB)