HAMAP rule MF_01401
General rule information
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| Accession | MF_01401 |
| Dates | 9-APR-2002 (Created)
1-JUN-2023 (Last updated, Version 30) |
| Name | MsrA |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P14930 (MSRAB_NEIGO); Q9JWM8 (MSRAB_NEIMA); [ Recover all ] |
| Triggered by |
HAMAP; MF_01401 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | MSRA |
| Protein name | RecName: Full=Peptide methionine sulfoxide reductase MsrA; Short=Protein-methionine-S-oxide reductase; EC=1.8.4.11; AltName: Full=Peptide-methionine (S)-S-oxide reductase; Short=Peptide Met(O) reductase; |
| Gene name | Name=msrA; |
Comments
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| FUNCTION | Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. |
| CATALYTIC ACTIVITY | Reaction=[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]; Xref=Rhea:RHEA:14217, Rhea:RHEA-COMP:10698, Rhea:RHEA-COMP:10700, Rhea:RHEA-COMP:12313, Rhea:RHEA-COMP:12315, ChEBI:CHEBI:15377, ChEBI:CHEBI:16044, ChEBI:CHEBI:29950, ChEBI:CHEBI:44120, ChEBI:CHEBI:50058; EC=1.8.4.11; |
| CATALYTIC ACTIVITY | Reaction=[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]- dithiol + L-methionine (S)-S-oxide; Xref=Rhea:RHEA:19993, Rhea:RHEA- COMP:10698, Rhea:RHEA-COMP:10700, ChEBI:CHEBI:15377, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058, ChEBI:CHEBI:57844, ChEBI:CHEBI:58772; EC=1.8.4.11; |
| SIMILARITY | Belongs to the MsrA Met sulfoxide reductase family. |
Keywords
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Gene Ontology
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| GO:0008113; Molecular function:peptide-methionine (S)-S-oxide reductase activity |
| GO:0036211; Biological process:protein modification process |
Cross-references
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Features
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| From: MSRA_ECOLI (P0A744) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 52 | 52 | C | |||||||||
Additional information
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| Size range | 123-222 amino acids |
| Related rules |
None |
| Fusion | Nter: MF_01400 (msrB); <Thioredoxin domain> Cter: MF_01400 (msrB) |