Home  |  Contact
Annotation rule MF_01405
Send feedback

General rule information [?]

Accession MF_01405
Dates 8-AUG-2002 (Created)
19-NOV-2019 (Last updated, Version 26)
Name Non_canon_purine_NTPase
Templates P52061 (IXTPA_ECOLI); Q57679 (IXTPA_METJA); O59580 (IXTPA_PYRHO); O28046 (IXTPA_ARCFU): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=dITP/XTP pyrophosphatase;
AltName: Full=Non-canonical purine NTP pyrophosphatase;
AltName: Full=Non-standard purine NTP pyrophosphatase;
AltName: Full=Nucleoside-triphosphate diphosphatase;
AltName: Full=Nucleoside-triphosphate pyrophosphatase;

Comments [?]

Function Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
Catalytic activity RHEA:28610: H2O + XTP = diphosphate + H(+) + XMP
RHEA:28342: dITP + H2O = dIMP + diphosphate + H(+)
RHEA:29399: H2O + ITP = diphosphate + H(+) + IMP
Cofactor Mg(2+)
Note: Binds 1 Mg(2+) ion per subunit.
Subunit Homodimer.
Similarity Belongs to the HAM1 NTPase family.

Keywords [?]

Gene Ontology [?]

GO:0047429; Molecular function: nucleoside-triphosphate diphosphatase activity.
GO:0009146; Biological process: purine nucleoside triphosphate catabolic process.

Cross-references [?]

Pfam PF01725; Ham1p_like; 1;
TIGRFAMs TIGR00042; TIGR00042; 1;

Features [?]

From: IXTPA_PYRHO (O59580)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     7     12       Substrate binding     [TS]-x-[NSH]-x-x-K  
REGION     140     143       Substrate binding     [FWH]-x-x-[DN]  
REGION     168     169       Substrate binding     H-R  
ACT_SITE     65     65       Proton acceptor     D  
METAL (Optional)     36     36       Magnesium     [ED]  
METAL     65     65       Magnesium     D  
BINDING     66     66       Substrate; via amide nitrogen     [STA]  
BINDING     163     163       Substrate     K  

Additional information [?]

Size range 178-328 amino acids
Related rules None
Fusion Nter: MF_00564 (rph), <Unknown>; Cter: None
Comments Unknown N-terminal domain in STRA3, STRA5, STRP1, STRP6, STRP8, STRT1, STRT2