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HAMAP rule MF_01405

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General rule information [?]

Accession MF_01405
Dates 8-AUG-2002 (Created)
1-JUN-2023 (Last updated, Version 31)
Name Non_canon_purine_NTPase
Scope(s) Bacteria
Template(s) P52061 (IXTPA_ECOLI); Q57679 (IXTPA_METJA); O59580 (IXTPA_PYRHO); O28046 (IXTPA_ARCFU); [ Recover all ]
Triggered by HAMAP; MF_01405 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier IXTPA
Protein name RecName: Full=dITP/XTP pyrophosphatase;
AltName: Full=Non-canonical purine NTP pyrophosphatase;
AltName: Full=Non-standard purine NTP pyrophosphatase;
AltName: Full=Nucleoside-triphosphate diphosphatase;
AltName: Full=Nucleoside-triphosphate pyrophosphatase;

Comments [?]

FUNCTIONPyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
CATALYTIC ACTIVITY Reaction=H2O + XTP = diphosphate + H(+) + XMP; Xref=Rhea:RHEA:28610, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:57464, ChEBI:CHEBI:61314; EC=;
CATALYTIC ACTIVITY Reaction=dITP + H2O = dIMP + diphosphate + H(+); Xref=Rhea:RHEA:28342, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:61194, ChEBI:CHEBI:61382; EC=;
CATALYTIC ACTIVITY Reaction=H2O + ITP = diphosphate + H(+) + IMP; Xref=Rhea:RHEA:29399, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:58053, ChEBI:CHEBI:61402; EC=;
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) ion per subunit.;
SIMILARITYBelongs to the HAM1 NTPase family.

Keywords [?]

Gene Ontology [?]

GO:0047429; Molecular function:nucleoside triphosphate diphosphatase activity
GO:0009146; Biological process:purine nucleoside triphosphate catabolic process

Cross-references [?]

Pfam PF01725; Ham1p_like; 1;
NCBIfam TIGR00042; TIGR00042; 1;

Features [?]

From: IXTPA_PYRHO (O59580)
Key From To Description Tag Condition FTGroup
BINDING 7 12 /ligand="substrate" [TS]-x-[NSH]-x-x-K
BINDING 140 143 /ligand="substrate" [FWH]-x-x-[DN]
BINDING 168 169 /ligand="substrate" H-R
ACT_SITE 65 65 /note="Proton acceptor" D
BINDING 36 36 /ligand="Mg(2+)"
BINDING 65 65 /ligand="Mg(2+)"
BINDING 66 66 /ligand="substrate" [STA]
BINDING 163 163 /ligand="substrate" K

Additional information [?]

Size range 178-328 amino acids
Related rules None
Fusion Nter: MF_00564 (rph); <Unknown> Cter: None
Comments Unknown N-terminal domain in STRA3, STRA5, STRP1, STRP6, STRP8, STRT1, STRT2

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