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Annotation rule MF_01405 |
Accession | MF_01405 |
Dates | 8-AUG-2002 (Created) 19-NOV-2019 (Last updated, Version 26) |
Name | Non_canon_purine_NTPase |
Scope | Bacteria
Archaea |
Templates | P52061 (IXTPA_ECOLI); Q57679 (IXTPA_METJA); O59580 (IXTPA_PYRHO); O28046 (IXTPA_ARCFU): [Recover all] |
Triggered by |
Identifier |
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Protein name |
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Function | Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. |
Catalytic activity | RHEA:28610: H2O + XTP = diphosphate + H(+) + XMP
EC 3.6.1.66 |
RHEA:28342: dITP + H2O = dIMP + diphosphate + H(+)
EC 3.6.1.66 |
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RHEA:29399: H2O + ITP = diphosphate + H(+) + IMP
EC 3.6.1.66 |
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Cofactor | Mg(2+) Note: Binds 1 Mg(2+) ion per subunit. |
Subunit | Homodimer. |
Similarity | Belongs to the HAM1 NTPase family. |
From: IXTPA_PYRHO (O59580) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
REGION | 7 | 12 | Substrate binding | [TS]-x-[NSH]-x-x-K | ||||||||
REGION | 140 | 143 | Substrate binding | [FWH]-x-x-[DN] | ||||||||
REGION | 168 | 169 | Substrate binding | H-R | ||||||||
ACT_SITE | 65 | 65 | Proton acceptor | D | ||||||||
METAL (Optional) | 36 | 36 | Magnesium | [ED] | ||||||||
METAL | 65 | 65 | Magnesium | D | ||||||||
BINDING | 66 | 66 | Substrate; via amide nitrogen | [STA] | ||||||||
BINDING | 163 | 163 | Substrate | K |
Size range | 178-328 amino acids |
Related rules | None |
Fusion | Nter: MF_00564 (rph), <Unknown>; Cter: None |
Comments | Unknown N-terminal domain in STRA3, STRA5, STRP1, STRP6, STRP8, STRT1, STRT2 |