HAMAP rule MF_01414
General rule information
[?]
Accession | MF_01414 |
Dates | 2-OCT-2003 (Created) 19-NOV-2022 (Last updated, Version 16) |
Name | K_H_efflux_KefF |
Scope | Bacteria; Gammaproteobacteria |
Template | P0A754 (KEFF_ECOLI) |
Triggered by |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Identifier |
|
Protein name |
|
Gene name |
|
Comments
[?]
Function | Regulatory subunit of a potassium efflux system that confers protection against electrophiles. Required for full activity of KefC. Shows redox enzymatic activity, but this enzymatic activity is not required for activation of KefC. |
Catalytic activity | RHEA:46160: a quinone + H(+) + NADH = a quinol + NAD(+)
EC 1.6.5.2 |
RHEA:46164: a quinone + H(+) + NADPH = a quinol + NADP(+)
EC 1.6.5.2 |
|
Cofactor | FMN |
Subunit | Homodimer. Interacts with KefC. |
Subcellular location | Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. |
Similarity | Belongs to the NAD(P)H dehydrogenase (quinone) family. KefF subfamily. |
Keywords
[?]
Gene Ontology
[?]
GO:0003955; Molecular function: NAD(P)H dehydrogenase (quinone) activity.
GO:0010181; Molecular function: FMN binding.
GO:0032414; Biological process: positive regulation of ion transmembrane transporter activity.
GO:1901381; Biological process: positive regulation of potassium ion transmembrane transport.
GO:0010181; Molecular function: FMN binding.
GO:0032414; Biological process: positive regulation of ion transmembrane transporter activity.
GO:1901381; Biological process: positive regulation of potassium ion transmembrane transport.
Cross-references
[?]
Pfam | PF02525; Flavodoxin_2; 1; |
Features
[?]
From: KEFF_ECOLI (P0A754) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING (Optional) | 14 | 17 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210 | S-x-x-N | ||||||||
BINDING (Optional) | 65 | 68 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210 | [ML]-x-W-Y | ||||||||
BINDING (Optional) | 105 | 108 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210 | T-x-G-x | ||||||||
BINDING (Optional) | 8 | 8 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210 | H |
Additional information
[?]
Size range | 160-200 amino acids |
Related rules | None |
Fusion | None |
Comments | KefF is the ancillary protein of KefC, whereas KefG is the ancillary protein of KefB. KefF and KefG cannot complement each other and are specific for their respective efflux system |