HAMAP rule MF_01415

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_01415
Accession	MF_01415
Dates	2-OCT-2003 (Created) 2-SEP-2024 (Last updated, Version 17)
Name	K_H_efflux_KefG
Scope(s)	Bacteria Gammaproteobacteria
Template(s)	P0A756 (KEFG_ECOLI); [ Recover all ]
Triggered by	HAMAP; MF_01415 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	KEFG
Protein name	RecName: Full=Glutathione-regulated potassium-efflux system ancillary protein KefG; AltName: Full=Putative quinone oxidoreductase KefG; EC=1.6.5.2;
Gene name	Name=kefG;

Comments [?]

FUNCTION	Regulatory subunit of a potassium efflux system that confers protection against electrophiles. Required for full activity of KefB.
CATALYTIC ACTIVITY	Reaction=a quinone + NADH + H(+) = a quinol + NAD(+); Xref=Rhea:RHEA:46160, ChEBI:CHEBI:15378, ChEBI:CHEBI:24646, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:132124; EC=1.6.5.2;
CATALYTIC ACTIVITY	Reaction=a quinone + NADPH + H(+) = a quinol + NADP(+); Xref=Rhea:RHEA:46164, ChEBI:CHEBI:15378, ChEBI:CHEBI:24646, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:132124; EC=1.6.5.2;
SUBUNIT	Interacts with KefB.
SUBCELLULAR LOCATION	Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
SIMILARITY	Belongs to the NAD(P)H dehydrogenase (quinone) family. KefG subfamily.

Keywords [?]

Gene Ontology [?]

GO:0003955; Molecular function:NAD(P)H dehydrogenase (quinone) activity

GO:0032414; Biological process:positive regulation of ion transmembrane transporter activity

GO:1901381; Biological process:positive regulation of potassium ion transmembrane transport

Cross-references [?]

Pfam	PF02525; Flavodoxin_2; 1;

Features [?]

Additional information [?]

Size range	175-233 amino acids
Related rules	None
Fusion	Nter: None Cter: None
Comments	KefF is the ancillary protein of KefC, whereas KefG is the ancillary protein of KefB. KefF and KefG cannot complement each other and are specific for their respective efflux system.