HAMAP rule MF_01415
General rule information
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PURL | https://purl.expasy.org/hamap/rule/MF_01415 |
Accession | MF_01415 |
Dates | 2-OCT-2003 (Created)
2-SEP-2024 (Last updated, Version 17) |
Name | K_H_efflux_KefG |
Scope(s) |
Bacteria Gammaproteobacteria |
Template(s) | P0A756 (KEFG_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_01415 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | KEFG |
Protein name | RecName: Full=Glutathione-regulated potassium-efflux system ancillary protein KefG; AltName: Full=Putative quinone oxidoreductase KefG; EC=1.6.5.2; |
Gene name | Name=kefG; |
Comments
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FUNCTION | Regulatory subunit of a potassium efflux system that confers protection against electrophiles. Required for full activity of KefB. |
CATALYTIC ACTIVITY | Reaction=a quinone + NADH + H(+) = a quinol + NAD(+); Xref=Rhea:RHEA:46160, ChEBI:CHEBI:15378, ChEBI:CHEBI:24646, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:132124; EC=1.6.5.2; |
CATALYTIC ACTIVITY | Reaction=a quinone + NADPH + H(+) = a quinol + NADP(+); Xref=Rhea:RHEA:46164, ChEBI:CHEBI:15378, ChEBI:CHEBI:24646, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:132124; EC=1.6.5.2; |
SUBUNIT | Interacts with KefB. |
SUBCELLULAR LOCATION | Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. |
SIMILARITY | Belongs to the NAD(P)H dehydrogenase (quinone) family. KefG subfamily. |
Keywords
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Gene Ontology
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GO:0003955; Molecular function:NAD(P)H dehydrogenase (quinone) activity |
GO:0032414; Biological process:positive regulation of ion transmembrane transporter activity |
GO:1901381; Biological process:positive regulation of potassium ion transmembrane transport |
Cross-references
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Pfam | PF02525; Flavodoxin_2; 1; |
Features
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Additional information
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Size range | 175-233 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |
Comments | KefF is the ancillary protein of KefC, whereas KefG is the ancillary protein of KefB. KefF and KefG cannot complement each other and are specific for their respective efflux system. |