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HAMAP rule MF_01415

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General rule information [?]

Accession MF_01415
Dates 2-OCT-2003 (Created)
19-NOV-2019 (Last updated, Version 16)
Name K_H_efflux_KefG
Scope(s) Bacteria
Template(s) P0A756 (KEFG_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01415 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier KEFG
Protein name RecName: Full=Glutathione-regulated potassium-efflux system ancillary protein KefG;
AltName: Full=Putative quinone oxidoreductase KefG;
Gene name Name=kefG;

Comments [?]

FUNCTIONRegulatory subunit of a potassium efflux system that confers protection against electrophiles. Required for full activity of KefB.
CATALYTIC ACTIVITY Reaction=a quinone + H(+) + NADH = a quinol + NAD(+); Xref=Rhea:RHEA:46160, ChEBI:CHEBI:15378, ChEBI:CHEBI:24646, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:132124; EC=;
CATALYTIC ACTIVITY Reaction=a quinone + H(+) + NADPH = a quinol + NADP(+); Xref=Rhea:RHEA:46164, ChEBI:CHEBI:15378, ChEBI:CHEBI:24646, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:132124; EC=;
SUBUNITInteracts with KefB.
SUBCELLULAR LOCATIONCell inner membrane; Peripheral membrane protein; Cytoplasmic side.
SIMILARITYBelongs to the NAD(P)H dehydrogenase (quinone) family. KefG subfamily.

Keywords [?]

Gene Ontology [?]

GO:0003955; Molecular function:NAD(P)H dehydrogenase (quinone) activity
GO:0032414; Biological process:positive regulation of ion transmembrane transporter activity
GO:1901381; Biological process:positive regulation of potassium ion transmembrane transport

Cross-references [?]

Pfam PF02525; Flavodoxin_2; 1;

Features [?]

Additional information [?]

Size range 175-233 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments KefF is the ancillary protein of KefC, whereas KefG is the ancillary protein of KefB. KefF and KefG cannot complement each other and are specific for their respective efflux system.

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