HAMAP rule MF_01417
General rule information
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Accession | MF_01417 |
Dates | 5-MAR-2004 (Created)
1-JUN-2023 (Last updated, Version 28) |
Name | SpeA |
Scope(s) |
Bacteria |
Template(s) | P21170 (SPEA_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_01417 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | SPEA |
Protein name | RecName: Full=Biosynthetic arginine decarboxylase; Short=ADC; EC=4.1.1.19; |
Gene name | Name=speA; |
Comments
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FUNCTION | Catalyzes the biosynthesis of agmatine from arginine. |
CATALYTIC ACTIVITY | Reaction=H(+) + L-arginine = agmatine + CO2; Xref=Rhea:RHEA:17641, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:32682, ChEBI:CHEBI:58145; EC=4.1.1.19; |
COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; |
COFACTOR | Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; |
PATHWAY | Amine and polyamine biosynthesis; agmatine biosynthesis; agmatine from L-arginine: step 1/1. |
SIMILARITY | Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily. |
Keywords
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Polyamine biosynthesis | |
Spermidine biosynthesis | |
case <OC:Enterobacterales> or <OC:Neisseriales> | |
Putrescine biosynthesis | |
end case | |
Lyase | |
Decarboxylase | |
Pyridoxal phosphate | |
Metal-binding | |
Magnesium |
Gene Ontology
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GO:0008792; Molecular function:arginine decarboxylase activity | |
case <OCellular component:Enterobacterales> or <OC:Neisseriales> | |
GO:0009446; Biological process:putrescine biosynthetic process | |
end case | |
GO:0008295; Biological process:spermidine biosynthetic process |
Cross-references
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Pfam | PF02784; Orn_Arg_deC_N; 1; |
Pfam | PF00278; Orn_DAP_Arg_deC; 1; |
PRINTS | PR01179; ODADCRBXLASE; 1; |
NCBIfam | TIGR01273; SpeA; 1; |
PROSITE | PS00878; ODR_DC_2_1; 1; |
PROSITE | PS00879; ODR_DC_2_2; 1; |
Features
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From: SPEA_ECOLI (P21170) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 307 | 317 | /ligand="substrate" | [FIVLC]-[DN]-[IV]-G-G-G-L-[GA]-[VI]-D-[YF] | ||||||||
MOD_RES | 127 | 127 | /note="N6-(pyridoxal phosphate)lysine" | K |
Additional information
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Size range | 626-695 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |