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HAMAP rule MF_01417

General rule information [?]

Accession	MF_01417
Dates	5-MAR-2004 (Created) 1-JUN-2023 (Last updated, Version 28)
Name	SpeA
Scope(s)	Bacteria
Template(s)	P21170 (SPEA_ECOLI); [ Recover all ]
Triggered by	HAMAP; MF_01417 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	SPEA
Protein name	RecName: Full=Biosynthetic arginine decarboxylase; Short=ADC; EC=4.1.1.19;
Gene name	Name=speA;

Comments [?]

FUNCTION	Catalyzes the biosynthesis of agmatine from arginine.
CATALYTIC ACTIVITY	Reaction=H(+) + L-arginine = agmatine + CO2; Xref=Rhea:RHEA:17641, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:32682, ChEBI:CHEBI:58145; EC=4.1.1.19;
COFACTOR	Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
COFACTOR	Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
PATHWAY	Amine and polyamine biosynthesis; agmatine biosynthesis; agmatine from L-arginine: step 1/1.
SIMILARITY	Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.

Keywords [?]

Polyamine biosynthesis
Spermidine biosynthesis
case <OC:Enterobacterales> or <OC:Neisseriales>
Putrescine biosynthesis
end case
Lyase
Decarboxylase
Pyridoxal phosphate
Metal-binding
Magnesium

Gene Ontology [?]

GO:0008792; Molecular function:arginine decarboxylase activity
case <OCellular component:Enterobacterales> or <OC:Neisseriales>
GO:0009446; Biological process:putrescine biosynthetic process
end case
GO:0008295; Biological process:spermidine biosynthetic process

Cross-references [?]

Features [?]

From: SPEA_ECOLI (P21170)

Key

From

Description

Tag

Condition

FTGroup

BINDING

307

317

/ligand="substrate"

[FIVLC]-[DN]-[IV]-G-G-G-L-[GA]-[VI]-D-[YF]

MOD_RES

127

/note="N6-(pyridoxal phosphate)lysine"

Additional information [?]