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| Annotation rule MF_01417 |
General rule information
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| Accession | MF_01417 |
| Dates | 5-MAR-2004 (Created) 19-NOV-2019 (Last updated, Version 25) |
| Name | SpeA |
| Scope | Bacteria |
| Template | P21170 (SPEA_ECOLI) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Catalyzes the biosynthesis of agmatine from arginine. |
| Catalytic activity | RHEA:17641: H(+) + L-arginine = agmatine + CO2
EC 4.1.1.19 |
| Cofactor | Mg(2+) |
| pyridoxal 5'-phosphate | |
| Pathway | Amine and polyamine biosynthesis; agmatine biosynthesis; agmatine from L-arginine: step 1/1. |
| Similarity | Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily. |
Keywords
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case <OC:Enterobacterales> or <OC:Neisseriales>
end case
Gene Ontology
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GO:0008792; Molecular function: arginine decarboxylase activity.
case <OC:Enterobacterales> or <OC:Neisseriales>
GO:0009446; Biological process: putrescine biosynthetic process.
end case
GO:0008295; Biological process: spermidine biosynthetic process.
Cross-references
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| Pfam | PF02784; Orn_Arg_deC_N; 1; |
| PF00278; Orn_DAP_Arg_deC; 1; | |
| PRINTS | PR01179; ODADCRBXLASE; 1; |
| TIGRFAMs | TIGR01273; SpeA; 1; |
| PROSITE | PS00878; ODR_DC_2_1; 1; |
| PS00879; ODR_DC_2_2; 1; |
Features
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| From: SPEA_ECOLI (P21170) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| REGION | 307 | 317 | Substrate-binding | [FIVLC]-[DN]-[IV]-G-G-G-L-[GA]-[VI]-D-[YF] | ||||||||
| MOD_RES | 127 | 127 | N6-(pyridoxal phosphate)lysine | K | ||||||||
Additional information
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| Size range | 626-695 amino acids |
| Related rules | None |
| Fusion | None |