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Annotation rule MF_01417
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General rule information [?]

Accession MF_01417
Dates 5-MAR-2004 (Created)
19-NOV-2019 (Last updated, Version 25)
Name SpeA
Scope
Bacteria
Template P21170 (SPEA_ECOLI)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
SPEA
Protein name
RecName: Full=Biosynthetic arginine decarboxylase;
Short=ADC;
EC 4.1.1.19;
Gene name
speA

Comments [?]

Function Catalyzes the biosynthesis of agmatine from arginine.
Catalytic activity RHEA:17641: H(+) + L-arginine = agmatine + CO2
EC 4.1.1.19
Cofactor Mg(2+)
pyridoxal 5'-phosphate
Pathway Amine and polyamine biosynthesis; agmatine biosynthesis; agmatine from L-arginine: step 1/1.
Similarity Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.

Keywords [?]

case <OC:Enterobacterales> or <OC:Neisseriales>
end case

Gene Ontology [?]

GO:0008792; Molecular function: arginine decarboxylase activity.
case <OC:Enterobacterales> or <OC:Neisseriales>
GO:0009446; Biological process: putrescine biosynthetic process.
end case
GO:0008295; Biological process: spermidine biosynthetic process.

Cross-references [?]

Pfam PF02784; Orn_Arg_deC_N; 1;
PF00278; Orn_DAP_Arg_deC; 1;
PRINTS PR01179; ODADCRBXLASE; 1;
TIGRFAMs TIGR01273; SpeA; 1;
PROSITE PS00878; ODR_DC_2_1; 1;
PS00879; ODR_DC_2_2; 1;

Features [?]

From: SPEA_ECOLI (P21170)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     307     317       Substrate-binding     [FIVLC]-[DN]-[IV]-G-G-G-L-[GA]-[VI]-D-[YF]  
MOD_RES     127     127       N6-(pyridoxal phosphate)lysine     K  

Additional information [?]

Size range 626-695 amino acids
Related rules None
Fusion None