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HAMAP rule MF_01417

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General rule information [?]

Accession MF_01417
Dates 5-MAR-2004 (Created)
1-JUN-2023 (Last updated, Version 28)
Name SpeA
Scope(s) Bacteria
Template(s) P21170 (SPEA_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01417 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier SPEA
Protein name RecName: Full=Biosynthetic arginine decarboxylase;
Gene name Name=speA;

Comments [?]

FUNCTIONCatalyzes the biosynthesis of agmatine from arginine.
CATALYTIC ACTIVITY Reaction=H(+) + L-arginine = agmatine + CO2; Xref=Rhea:RHEA:17641, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:32682, ChEBI:CHEBI:58145; EC=;
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
COFACTOR Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
PATHWAYAmine and polyamine biosynthesis; agmatine biosynthesis; agmatine from L-arginine: step 1/1.
SIMILARITYBelongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.

Keywords [?]

Gene Ontology [?]

GO:0008792; Molecular function:arginine decarboxylase activity
case <OCellular component:Enterobacterales> or <OC:Neisseriales>
GO:0009446; Biological process:putrescine biosynthetic process
end case
GO:0008295; Biological process:spermidine biosynthetic process

Cross-references [?]

Pfam PF02784; Orn_Arg_deC_N; 1;
Pfam PF00278; Orn_DAP_Arg_deC; 1;
NCBIfam TIGR01273; SpeA; 1;
PROSITE PS00878; ODR_DC_2_1; 1;
PROSITE PS00879; ODR_DC_2_2; 1;

Features [?]

From: SPEA_ECOLI (P21170)
Key From To Description Tag Condition FTGroup
BINDING 307 317 /ligand="substrate" [FIVLC]-[DN]-[IV]-G-G-G-L-[GA]-[VI]-D-[YF]
MOD_RES 127 127 /note="N6-(pyridoxal phosphate)lysine" K

Additional information [?]

Size range 626-695 amino acids
Related rules None
Fusion Nter: None Cter: None

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