HAMAP rule MF_01417
General rule information
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| Accession | MF_01417 |
| Dates | 5-MAR-2004 (Created)
2-SEP-2024 (Last updated, Version 29) |
| Name | SpeA |
| Scope(s) |
Bacteria |
| Template(s) | P21170 (SPEA_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01417 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | SPEA |
| Protein name | RecName: Full=Biosynthetic arginine decarboxylase; Short=ADC; EC=4.1.1.19; |
| Gene name | Name=speA; |
Comments
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| FUNCTION | Catalyzes the biosynthesis of agmatine from arginine. |
| CATALYTIC ACTIVITY | Reaction=L-arginine + H(+) = agmatine + CO2; Xref=Rhea:RHEA:17641, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:32682, ChEBI:CHEBI:58145; EC=4.1.1.19; |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; |
| COFACTOR | Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; |
| PATHWAY | Amine and polyamine biosynthesis; agmatine biosynthesis; agmatine from L-arginine: step 1/1. |
| SIMILARITY | Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily. |
Keywords
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| Polyamine biosynthesis | |
| Spermidine biosynthesis | |
| case <OC:Enterobacterales> or <OC:Neisseriales> | |
| Putrescine biosynthesis | |
| end case | |
| Lyase | |
| Decarboxylase | |
| Pyridoxal phosphate | |
| Metal-binding | |
| Magnesium | |
Gene Ontology
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| GO:0008792; Molecular function:arginine decarboxylase activity | |
| case <OCellular component:Enterobacterales> or <OC:Neisseriales> | |
| GO:0009446; Biological process:putrescine biosynthetic process | |
| end case | |
| GO:0008295; Biological process:spermidine biosynthetic process | |
Cross-references
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| Pfam | PF02784; Orn_Arg_deC_N; 1; |
| Pfam | PF00278; Orn_DAP_Arg_deC; 1; |
| PRINTS | PR01179; ODADCRBXLASE; 1; |
| NCBIfam | TIGR01273; SpeA; 1; |
| PROSITE | PS00878; ODR_DC_2_1; 1; |
| PROSITE | PS00879; ODR_DC_2_2; 1; |
Features
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| From: SPEA_ECOLI (P21170) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 307 | 317 | /ligand="substrate" | [FIVLC]-[DN]-[IV]-G-G-G-L-[GA]-[VI]-D-[YF] | ||||||||
| MOD_RES | 127 | 127 | /note="N6-(pyridoxal phosphate)lysine" | K | ||||||||
Additional information
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| Size range | 626-695 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |