HAMAP rule MF_01425

General rule information [?]

Accession	MF_01425
Dates	14-FEB-2005 (Created) 1-JUN-2023 (Last updated, Version 27)

Name	Cation_efflux_FieF

Scope

Bacteria; Enterobacterales

Template

P69380 (FIEF_ECOLI)

Triggered by

HAMAP; MF_01425 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

FIEF

Protein name

RecName:

Full=Cation-efflux pump FieF;

Gene name

fieF

Comments [?]

Function	Divalent metal cation transporter which exports Zn(2+), Cd(2+) and possibly Fe(2+). May be involved in zinc and iron detoxification by efflux.
Catalytic activity	RHEA:28839: H(+)(out) + Zn(2+)(in) = H(+)(in) + Zn(2+)(out)
	RHEA:28739: Cd(2+)(in) + H(+)(out) = Cd(2+)(out) + H(+)(in)
	RHEA:29439: Fe(2+)(in) + H(+)(out) = Fe(2+)(out) + H(+)(in)
Subunit	Homodimer.
Subcellular location	Cell inner membrane; Multi-pass membrane protein.
Similarity	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. FieF subfamily.

Keywords [?]

Cell inner membrane
Cell membrane
Ion transport
Iron
Iron transport
Membrane
Metal-binding
Transmembrane
Transmembrane helix
Zinc
Zinc transport

Gene Ontology [?]

GO:0015297; Molecular function: antiporter activity.
GO:0015086; Molecular function: cadmium ion transmembrane transporter activity.
GO:0005381; Molecular function: iron ion transmembrane transporter activity.
GO:0005385; Molecular function: zinc ion transmembrane transporter activity.
GO:0070574; Biological process: cadmium ion transmembrane transport.
GO:0034755; Biological process: iron ion transmembrane transport.
GO:0071577; Biological process: zinc ion transmembrane transport.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam	PF01545; Cation_efflux; 1;
NCBIfam	TIGR01297; CDF; 1;

Computed features [?]

General

Transmembrane; -; 5-6; trigger=yes;

Features [?]

From: FIEF_ECOLI (P69380)

Key From To Description Tag Condition FTGroup

BINDING 45 45 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 D

BINDING 49 49 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 D

BINDING 153 153 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 H

BINDING 157 157 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 D

Additional information [?]

Size range	280-320 amino acids
Related rules	None
Fusion	None

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