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HAMAP rule MF_01425

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General rule information [?]

Accession MF_01425
Dates 14-FEB-2005 (Created)
1-JUN-2023 (Last updated, Version 27)
Name Cation_efflux_FieF
Bacteria; Enterobacterales
Template P69380 (FIEF_ECOLI)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Cation-efflux pump FieF;
Gene name

Comments [?]

Function Divalent metal cation transporter which exports Zn(2+), Cd(2+) and possibly Fe(2+). May be involved in zinc and iron detoxification by efflux.
Catalytic activity RHEA:28839: H(+)(out) + Zn(2+)(in) = H(+)(in) + Zn(2+)(out)
RHEA:28739: Cd(2+)(in) + H(+)(out) = Cd(2+)(out) + H(+)(in)
RHEA:29439: Fe(2+)(in) + H(+)(out) = Fe(2+)(out) + H(+)(in)
Subunit Homodimer.
Subcellular location Cell inner membrane; Multi-pass membrane protein.
Similarity Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. FieF subfamily.

Keywords [?]

Gene Ontology [?]

GO:0015297; Molecular function: antiporter activity.
GO:0015086; Molecular function: cadmium ion transmembrane transporter activity.
GO:0005381; Molecular function: iron ion transmembrane transporter activity.
GO:0005385; Molecular function: zinc ion transmembrane transporter activity.
GO:0070574; Biological process: cadmium ion transmembrane transport.
GO:0034755; Biological process: iron ion transmembrane transport.
GO:0071577; Biological process: zinc ion transmembrane transport.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam PF01545; Cation_efflux; 1;
NCBIfam TIGR01297; CDF; 1;

Computed features [?]

General Transmembrane; -; 5-6; trigger=yes;

Features [?]

From: FIEF_ECOLI (P69380)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     45     45       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     D  
BINDING     49     49       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     D  
BINDING     153     153       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     H  
BINDING     157     157       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     D  

Additional information [?]

Size range 280-320 amino acids
Related rules None
Fusion None