HAMAP rule MF_01425
General rule information
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| Accession | MF_01425 |
| Dates | 14-FEB-2005 (Created)
1-JUN-2023 (Last updated, Version 27) |
| Name | Cation_efflux_FieF |
| Scope(s) |
Bacteria Enterobacterales |
| Template(s) | P69380 (FIEF_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01425 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | FIEF |
| Protein name | RecName: Full=Cation-efflux pump FieF; |
| Gene name | Name=fieF; |
Comments
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| FUNCTION | Divalent metal cation transporter which exports Zn(2+), Cd(2+) and possibly Fe(2+). May be involved in zinc and iron detoxification by efflux. |
| CATALYTIC ACTIVITY | Reaction=H(+)(out) + Zn(2+)(in) = H(+)(in) + Zn(2+)(out); Xref=Rhea:RHEA:28839, ChEBI:CHEBI:15378, ChEBI:CHEBI:29105; |
| CATALYTIC ACTIVITY | Reaction=Cd(2+)(in) + H(+)(out) = Cd(2+)(out) + H(+)(in); Xref=Rhea:RHEA:28739, ChEBI:CHEBI:15378, ChEBI:CHEBI:48775; |
| CATALYTIC ACTIVITY | Reaction=Fe(2+)(in) + H(+)(out) = Fe(2+)(out) + H(+)(in); Xref=Rhea:RHEA:29439, ChEBI:CHEBI:15378, ChEBI:CHEBI:29033; |
| SUBUNIT | Homodimer. |
| SUBCELLULAR LOCATION | Cell inner membrane; Multi-pass membrane protein. |
| SIMILARITY | Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. FieF subfamily. |
Keywords
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| Cell inner membrane |
| Cell membrane |
| Ion transport |
| Iron |
| Iron transport |
| Membrane |
| Metal-binding |
| Transmembrane |
| Transmembrane helix |
| Zinc |
| Zinc transport |
Gene Ontology
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| GO:0015297; Molecular function:antiporter activity |
| GO:0015086; Molecular function:cadmium ion transmembrane transporter activity |
| GO:0005381; Molecular function:iron ion transmembrane transporter activity |
| GO:0005385; Molecular function:zinc ion transmembrane transporter activity |
| GO:0070574; Biological process:cadmium ion transmembrane transport |
| GO:0034755; Biological process:iron ion transmembrane transport |
| GO:0071577; Biological process:zinc ion transmembrane transport |
| GO:0005886; Cellular component:plasma membrane |
Cross-references
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| Pfam | PF01545; Cation_efflux; 1; |
| NCBIfam | TIGR01297; CDF; 1; |
| General | Transmembrane; -; 5-6; |
Features
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| From: FIEF_ECOLI (P69380) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 45 | 45 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
D | ||||||||
| BINDING | 49 | 49 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
D | ||||||||
| BINDING | 153 | 153 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
H | ||||||||
| BINDING | 157 | 157 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
D | ||||||||
Additional information
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| Size range | 280-320 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |