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HAMAP rule MF_01425

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General rule information [?]

Accession MF_01425
Dates 14-FEB-2005 (Created)
1-JUN-2023 (Last updated, Version 27)
Name Cation_efflux_FieF
Scope(s) Bacteria
Template(s) P69380 (FIEF_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01425 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier FIEF
Protein name RecName: Full=Cation-efflux pump FieF;
Gene name Name=fieF;

Comments [?]

FUNCTIONDivalent metal cation transporter which exports Zn(2+), Cd(2+) and possibly Fe(2+). May be involved in zinc and iron detoxification by efflux.
CATALYTIC ACTIVITY Reaction=H(+)(out) + Zn(2+)(in) = H(+)(in) + Zn(2+)(out); Xref=Rhea:RHEA:28839, ChEBI:CHEBI:15378, ChEBI:CHEBI:29105;
CATALYTIC ACTIVITY Reaction=Cd(2+)(in) + H(+)(out) = Cd(2+)(out) + H(+)(in); Xref=Rhea:RHEA:28739, ChEBI:CHEBI:15378, ChEBI:CHEBI:48775;
CATALYTIC ACTIVITY Reaction=Fe(2+)(in) + H(+)(out) = Fe(2+)(out) + H(+)(in); Xref=Rhea:RHEA:29439, ChEBI:CHEBI:15378, ChEBI:CHEBI:29033;
SUBCELLULAR LOCATIONCell inner membrane; Multi-pass membrane protein.
SIMILARITYBelongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. FieF subfamily.

Keywords [?]

Gene Ontology [?]

GO:0015297; Molecular function:antiporter activity
GO:0015086; Molecular function:cadmium ion transmembrane transporter activity
GO:0005381; Molecular function:iron ion transmembrane transporter activity
GO:0005385; Molecular function:zinc ion transmembrane transporter activity
GO:0070574; Biological process:cadmium ion transmembrane transport
GO:0034755; Biological process:iron ion transmembrane transport
GO:0071577; Biological process:zinc ion transmembrane transport
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam PF01545; Cation_efflux; 1;
NCBIfam TIGR01297; CDF; 1;
General Transmembrane; -; 5-6;

Features [?]

From: FIEF_ECOLI (P69380)
Key From To Description Tag Condition FTGroup
BINDING 45 45 /ligand="Zn(2+)"
BINDING 49 49 /ligand="Zn(2+)"
BINDING 153 153 /ligand="Zn(2+)"
BINDING 157 157 /ligand="Zn(2+)"

Additional information [?]

Size range 280-320 amino acids
Related rules None
Fusion Nter: None Cter: None

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