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HAMAP rule MF_01429

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General rule information [?]

Accession MF_01429
Dates 27-OCT-2005 (Created)
1-JUN-2023 (Last updated, Version 19)
Name Fe_S_insert_IscA
Scope(s) Bacteria
Template(s) P0AAC8 (ISCA_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01429 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier ISCA
Protein name RecName: Full=Iron-binding protein IscA;
AltName: Full=Iron-sulfur cluster assembly protein;
Gene name Name=iscA;

Comments [?]

FUNCTIONIs able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system TrxA/TrxB.
case <FTGroup:1>
COFACTOR Name=Fe cation; Xref=ChEBI:CHEBI:24875; Note=Binds 2 iron ions per dimer. The dimer may bind additional iron ions.;
end case
SUBUNITHomodimer; may form tetramers and higher multimers.
SIMILARITYBelongs to the HesB/IscA family.

Keywords [?]

case <FTGroup:1>
end case

Gene Ontology [?]

GO:0005506; Molecular function:iron ion binding
case <FTGroup:1>
GO:0016226; Biological process:iron-sulfur cluster assembly
end case

Cross-references [?]

Pfam PF01521; Fe-S_biosyn; 1;
NCBIfam TIGR00049; TIGR00049; 1;
NCBIfam TIGR02011; IscA; 1;

Features [?]

Key From To Description Tag Condition FTGroup
BINDING 35 35 /ligand="Fe cation"
C 1
BINDING 99 99 /ligand="Fe cation"
C 1
BINDING 101 101 /ligand="Fe cation"
C 1

Additional information [?]

Size range 107-107 amino acids
Related rules None
Fusion Nter: None Cter: None

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