HAMAP rule MF_01429
General rule information
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| Accession | MF_01429 |
| Dates | 27-OCT-2005 (Created) 19-NOV-2022 (Last updated, Version 18) |
| Name | Fe_S_insert_IscA |
| Scope | Bacteria; Enterobacterales |
| Template | P0AAC8 (ISCA_ECOLI) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system TrxA/TrxB. |
case <FTGroup:1>
| Cofactor | Fe cation Note: Binds 2 iron ions per dimer. The dimer may bind additional iron ions. |
end case
| Subunit | Homodimer; may form tetramers and higher multimers. |
| Similarity | Belongs to the HesB/IscA family. |
Keywords
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case <FTGroup:1>
end case
Gene Ontology
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GO:0005506; Molecular function: iron ion binding.
case <FTGroup:1>
GO:0016226; Biological process: iron-sulfur cluster assembly.
end case
Cross-references
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| Pfam | PF01521; Fe-S_biosyn; 1; |
| TIGRFAMs | TIGR00049; TIGR00049; 1; |
| TIGR02011; IscA; 1; | |
| PROSITE | PS01152; HESB; 1; |
Features
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| From: ISCA_ECOLI (P0AAC8) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 35 | 35 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875 | C | 1 | |||||||
| BINDING | 99 | 99 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875 | C | 1 | |||||||
| BINDING | 101 | 101 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875 | C | 1 | |||||||
Additional information
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| Size range | 107-107 amino acids |
| Related rules | None |
| Fusion | None |