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Annotation rule MF_01429
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General rule information [?]

Accession MF_01429
Dates 27-OCT-2005 (Created)
19-NOV-2019 (Last updated, Version 16)
Name Fe_S_insert_IscA
Scope
Bacteria; Enterobacterales
Template P0AAC8 (ISCA_ECOLI)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
ISCA
Protein name
RecName: Full=Iron-binding protein IscA;
AltName: Full=Iron-sulfur cluster assembly protein;
Gene name
iscA

Comments [?]

Function Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system TrxA/TrxB.
case <FTGroup:1>
Cofactor Fe cation
Note: Binds 2 iron ions per dimer. The dimer may bind additional iron ions.
end case
Subunit Homodimer; may form tetramers and higher multimers.
Similarity Belongs to the HesB/IscA family.

Keywords [?]

Iron
case <FTGroup:1>
Metal-binding
end case

Gene Ontology [?]

GO:0005506; Molecular function: iron ion binding.
case <FTGroup:1>
GO:0016226; Biological process: iron-sulfur cluster assembly.
end case

Cross-references [?]

Pfam PF01521; Fe-S_biosyn; 1;
TIGRFAMs TIGR00049; TIGR00049; 1;
TIGR02011; IscA; 1;
PROSITE PS01152; HESB; 1;

Features [?]

From: ISCA_ECOLI (P0AAC8)
Key     From     To       Description   Tag   Condition   FTGroup
METAL     35     35       Iron     C   1
METAL     99     99       Iron     C   1
METAL     101     101       Iron     C   1

Additional information [?]

Size range 107-107 amino acids
Related rules None
Fusion None


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