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HAMAP rule MF_01429

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General rule information [?]

Accession MF_01429
Dates 27-OCT-2005 (Created)
19-NOV-2022 (Last updated, Version 18)
Name Fe_S_insert_IscA
Bacteria; Enterobacterales
Template P0AAC8 (ISCA_ECOLI)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Iron-binding protein IscA;
AltName: Full=Iron-sulfur cluster assembly protein;
Gene name

Comments [?]

Function Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system TrxA/TrxB.
case <FTGroup:1>
Cofactor Fe cation
Note: Binds 2 iron ions per dimer. The dimer may bind additional iron ions.
end case
Subunit Homodimer; may form tetramers and higher multimers.
Similarity Belongs to the HesB/IscA family.

Keywords [?]

case <FTGroup:1>
end case

Gene Ontology [?]

GO:0005506; Molecular function: iron ion binding.
case <FTGroup:1>
GO:0016226; Biological process: iron-sulfur cluster assembly.
end case

Cross-references [?]

Pfam PF01521; Fe-S_biosyn; 1;
TIGRFAMs TIGR00049; TIGR00049; 1;
TIGR02011; IscA; 1;

Features [?]

Key     From     To       Description   Tag   Condition   FTGroup
BINDING     35     35       /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875     C   1
BINDING     99     99       /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875     C   1
BINDING     101     101       /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875     C   1

Additional information [?]

Size range 107-107 amino acids
Related rules None
Fusion None