HAMAP rule MF_01437

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_01437
Accession	MF_01437
Dates	15-MAY-2006 (Created) 27-MAR-2025 (Last updated, Version 25)
Name	PgsA
Scope(s)	Bacteria Enterobacterales
Template(s)	P0ABF8; [ Recover all ]
Triggered by	HAMAP; MF_01437 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	PGSA
Protein name	RecName: Full=CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; EC=2.7.8.5; AltName: Full=Phosphatidylglycerophosphate synthase; Short=PGP synthase;
Gene name	Name=pgsA;

Comments [?]

FUNCTION	Catalyzes the conversion of cytidine diphosphate diacylglycerol (CDP-DG) and glycerol 3-phosphate into phosphatidylglycerol. Essential for the synthesis of anionic phospholipids, thereby playing a role in balancing the ratio of zwitterionic and anionic phospholipids, which is thought to be important for normal membrane function.
CATALYTIC ACTIVITY	Reaction=a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+); Xref=Rhea:RHEA:12593, ChEBI:CHEBI:15378, ChEBI:CHEBI:57597, ChEBI:CHEBI:58332, ChEBI:CHEBI:60110, ChEBI:CHEBI:60377; EC=2.7.8.5;
PATHWAY	Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.
SUBCELLULAR LOCATION	Cell inner membrane; Multi-pass membrane protein.
SIMILARITY	Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

Keywords [?]

Gene Ontology [?]

GO:0008444; Molecular function:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity

GO:0006655; Biological process:phosphatidylglycerol biosynthetic process

GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Features [?]

Additional information [?]