HAMAP rule MF_01437

Accession	MF_01437
Dates	15-MAY-2006 (Created) 19-NOV-2019 (Last updated, Version 20)

Name

PgsA

Scope

Bacteria; Enterobacterales

Template

P0ABF8 (PGSA_ECOLI)

Triggered by

HAMAP; MF_01437 (Get profile general information and statistics)

Identifier

PGSA

Protein name

RecName: Full=CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; EC 2.7.8.5; AltName: Full=Phosphatidylglycerophosphate synthase; Short=PGP synthase;

Gene name

pgsA

Function	This protein catalyzes the committed step to the synthesis of the acidic phospholipids.
Catalytic activity	RHEA:12593: a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+) EC 2.7.8.5
Pathway	Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.
Subcellular location	Cell inner membrane; Multi-pass membrane protein.
Similarity	Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

Cell membrane
Cell inner membrane
Lipid biosynthesis
Lipid metabolism
Membrane
Phospholipid biosynthesis
Phospholipid metabolism
Transferase
Transmembrane
Transmembrane helix

GO:0008444; Molecular function: CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity.
GO:0008654; Biological process: phospholipid biosynthetic process.
GO:0005886; Cellular component: plasma membrane.

PROSITE	PS00379; CDP_ALCOHOL_P_TRANSF; 1;
Pfam	PF01066; CDP-OH_P_transf; 1;
TIGRFAMs	TIGR00560; PgsA; 1;

From: PGSA_ECOLI (P0ABF8)
Key		From		To		Description		Tag		Condition		FTGroup
TOPO_DOM		1		12		Cytoplasmic
TRANSMEM		13		37		Helical
TOPO_DOM		38		60		Periplasmic
TRANSMEM		61		81		Helical
TOPO_DOM		82		86		Cytoplasmic
TRANSMEM		87		107		Helical
TOPO_DOM		108		145		Periplasmic
TRANSMEM		146		168		Helical
TOPO_DOM		169		181		Cytoplasmic

Size range	181-190 amino acids
Related rules	None
Fusion	None

View rule in raw text format (no links)