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HAMAP rule MF_01437

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General rule information [?]

Accession MF_01437
Dates 15-MAY-2006 (Created)
2-FEB-2024 (Last updated, Version 22)
Name PgsA
Scope(s) Bacteria
Template(s) P0ABF8 (PGSA_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01437 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier PGSA
Protein name RecName: Full=CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase;
AltName: Full=Phosphatidylglycerophosphate synthase;
                 Short=PGP synthase;
Gene name Name=pgsA;

Comments [?]

FUNCTIONThis protein catalyzes the committed step to the synthesis of the acidic phospholipids.
CATALYTIC ACTIVITY Reaction=a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = 1,2- diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+); Xref=Rhea:RHEA:12593, ChEBI:CHEBI:15378, ChEBI:CHEBI:57597, ChEBI:CHEBI:58332, ChEBI:CHEBI:60110, ChEBI:CHEBI:60377; EC=;
PATHWAYPhospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.
SUBCELLULAR LOCATIONCell inner membrane; Multi-pass membrane protein.
SIMILARITYBelongs to the CDP-alcohol phosphatidyltransferase class-I family.

Keywords [?]

Gene Ontology [?]

GO:0008444; Molecular function:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity
GO:0006655; Biological process:phosphatidylglycerol biosynthetic process
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam PF01066; CDP-OH_P_transf; 1;
NCBIfam TIGR00560; PgsA; 1;

Features [?]

Key From To Description Tag Condition FTGroup
TOPO_DOM 1 12 /note="Cytoplasmic"
TRANSMEM 13 37 /note="Helical"
TOPO_DOM 38 60 /note="Periplasmic"
TRANSMEM 61 81 /note="Helical"
TOPO_DOM 82 86 /note="Cytoplasmic"
TRANSMEM 87 107 /note="Helical"
TOPO_DOM 108 145 /note="Periplasmic"
TRANSMEM 146 168 /note="Helical"
TOPO_DOM 169 181 /note="Cytoplasmic"

Additional information [?]

Size range 181-190 amino acids
Related rules None
Fusion Nter: None Cter: None

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