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| Annotation rule MF_01437 |
General rule information
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| Accession | MF_01437 |
| Dates | 15-MAY-2006 (Created) 19-NOV-2019 (Last updated, Version 20) |
| Name | PgsA |
| Scope | Bacteria; Enterobacterales |
| Template | P0ABF8 (PGSA_ECOLI) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | This protein catalyzes the committed step to the synthesis of the acidic phospholipids. |
| Catalytic activity | RHEA:12593: a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)
EC 2.7.8.5 |
| Pathway | Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2. |
| Subcellular location | Cell inner membrane; Multi-pass membrane protein. |
| Similarity | Belongs to the CDP-alcohol phosphatidyltransferase class-I family. |
Keywords
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Cell membrane
Cell inner membrane
Lipid biosynthesis
Lipid metabolism
Membrane
Phospholipid biosynthesis
Phospholipid metabolism
Transferase
Transmembrane
Transmembrane helix
Cell inner membrane
Lipid biosynthesis
Lipid metabolism
Membrane
Phospholipid biosynthesis
Phospholipid metabolism
Transferase
Transmembrane
Transmembrane helix
Gene Ontology
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GO:0008444; Molecular function: CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity.
GO:0008654; Biological process: phospholipid biosynthetic process.
GO:0005886; Cellular component: plasma membrane.
GO:0008654; Biological process: phospholipid biosynthetic process.
GO:0005886; Cellular component: plasma membrane.
Cross-references
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| PROSITE | PS00379; CDP_ALCOHOL_P_TRANSF; 1; |
| Pfam | PF01066; CDP-OH_P_transf; 1; |
| TIGRFAMs | TIGR00560; PgsA; 1; |
Features
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| From: PGSA_ECOLI (P0ABF8) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| TOPO_DOM | 1 | 12 | Cytoplasmic | |||||||||
| TRANSMEM | 13 | 37 | Helical | |||||||||
| TOPO_DOM | 38 | 60 | Periplasmic | |||||||||
| TRANSMEM | 61 | 81 | Helical | |||||||||
| TOPO_DOM | 82 | 86 | Cytoplasmic | |||||||||
| TRANSMEM | 87 | 107 | Helical | |||||||||
| TOPO_DOM | 108 | 145 | Periplasmic | |||||||||
| TRANSMEM | 146 | 168 | Helical | |||||||||
| TOPO_DOM | 169 | 181 | Cytoplasmic | |||||||||
Additional information
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| Size range | 181-190 amino acids |
| Related rules | None |
| Fusion | None |