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Annotation rule MF_01437 |
Accession | MF_01437 |
Dates | 15-MAY-2006 (Created) 19-NOV-2019 (Last updated, Version 20) |
Name | PgsA |
Scope | Bacteria; Enterobacterales |
Template | P0ABF8 (PGSA_ECOLI) |
Triggered by |
Identifier |
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Protein name |
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Gene name |
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Function | This protein catalyzes the committed step to the synthesis of the acidic phospholipids. |
Catalytic activity | RHEA:12593: a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)
EC 2.7.8.5 |
Pathway | Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2. |
Subcellular location | Cell inner membrane; Multi-pass membrane protein. |
Similarity | Belongs to the CDP-alcohol phosphatidyltransferase class-I family. |
PROSITE | PS00379; CDP_ALCOHOL_P_TRANSF; 1; |
Pfam | PF01066; CDP-OH_P_transf; 1; |
TIGRFAMs | TIGR00560; PgsA; 1; |
From: PGSA_ECOLI (P0ABF8) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
TOPO_DOM | 1 | 12 | Cytoplasmic | |||||||||
TRANSMEM | 13 | 37 | Helical | |||||||||
TOPO_DOM | 38 | 60 | Periplasmic | |||||||||
TRANSMEM | 61 | 81 | Helical | |||||||||
TOPO_DOM | 82 | 86 | Cytoplasmic | |||||||||
TRANSMEM | 87 | 107 | Helical | |||||||||
TOPO_DOM | 108 | 145 | Periplasmic | |||||||||
TRANSMEM | 146 | 168 | Helical | |||||||||
TOPO_DOM | 169 | 181 | Cytoplasmic |
Size range | 181-190 amino acids |
Related rules | None |
Fusion | None |