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Annotation rule MF_01437
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General rule information [?]

Accession MF_01437
Dates 15-MAY-2006 (Created)
19-NOV-2019 (Last updated, Version 20)
Name PgsA
Scope
Bacteria; Enterobacterales
Template P0ABF8 (PGSA_ECOLI)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
PGSA
Protein name
RecName: Full=CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase;
EC 2.7.8.5;
AltName: Full=Phosphatidylglycerophosphate synthase;
Short=PGP synthase;
Gene name
pgsA

Comments [?]

Function This protein catalyzes the committed step to the synthesis of the acidic phospholipids.
Catalytic activity RHEA:12593: a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)
EC 2.7.8.5
Pathway Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.
Subcellular location Cell inner membrane; Multi-pass membrane protein.
Similarity Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

Keywords [?]


Gene Ontology [?]

GO:0008444; Molecular function: CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity.
GO:0008654; Biological process: phospholipid biosynthetic process.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

PROSITE PS00379; CDP_ALCOHOL_P_TRANSF; 1;
Pfam PF01066; CDP-OH_P_transf; 1;
TIGRFAMs TIGR00560; PgsA; 1;

Features [?]

From: PGSA_ECOLI (P0ABF8)
Key     From     To       Description   Tag   Condition   FTGroup
TOPO_DOM     1     12       Cytoplasmic        
TRANSMEM     13     37       Helical        
TOPO_DOM     38     60       Periplasmic        
TRANSMEM     61     81       Helical        
TOPO_DOM     82     86       Cytoplasmic        
TRANSMEM     87     107       Helical        
TOPO_DOM     108     145       Periplasmic        
TRANSMEM     146     168       Helical        
TOPO_DOM     169     181       Cytoplasmic        

Additional information [?]

Size range 181-190 amino acids
Related rules None
Fusion None