HAMAP rule MF_01438
General rule information
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| Accession | MF_01438 |
| Dates | 7-JUN-2006 (Created) 13-JAN-2023 (Last updated, Version 20) |
| Name | DisA |
| Scope | Bacteria; Actinomycetota
Bacteria; Bacillaceae
Bacteria; Clostridia
Bacteria; Fusobacterium
Bacteria; Thermotoga |
| Templates | P37573 (DISA_BACSU); Q9WY43 (DISA_THEMA); P9WNW5 (DISA_MYCTU); A0R564 (DISA_MYCS2); Q9X8L6 (DISA_STRCO); A0R8F5 (DISA_BACAH); Q6HPT4 (DISA_BACHK): [Recover all] |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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case <OC:Bacillaceae> or <OC:Clostridia> or <OC:Frankia> or <OC:Streptomyces>
| Function | Participates in a DNA-damage check-point that is active prior to asymmetric division when DNA is damaged. DisA forms globular foci that rapidly scan along the chromosomes during sporulation, searching for lesions. When a lesion is present, DisA pauses at the lesion site. This triggers a cellular response that culminates in a temporary block in sporulation initiation. |
| Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis. |
else
| Function | Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions. |
| Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process. |
end case
| Catalytic activity | RHEA:35655: 2 ATP = 3',3'-c-di-AMP + 2 diphosphate
EC 2.7.7.85 |
| Cofactor | Mg(2+) |
| Subunit | Homooctamer. |
| Similarity | Belongs to the DisA family. |
Keywords
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ATP-binding
DNA damage
DNA repair
DNA-binding
Nucleotide-binding
Nucleotidyltransferase
Magnesium
Transferase
DNA damage
DNA repair
DNA-binding
Nucleotide-binding
Nucleotidyltransferase
Magnesium
Transferase
Gene Ontology
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GO:0003677; Molecular function: DNA binding.
GO:0005524; Molecular function: ATP binding.
GO:0016779; Molecular function: nucleotidyltransferase activity.
GO:0006281; Biological process: DNA repair.
GO:0019932; Biological process: second-messenger-mediated signaling.
GO:0005524; Molecular function: ATP binding.
GO:0016779; Molecular function: nucleotidyltransferase activity.
GO:0006281; Biological process: DNA repair.
GO:0019932; Biological process: second-messenger-mediated signaling.
Cross-references
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| PROSITE | PS51794; DAC; 1; trigger=PRU01130; |
| Pfam | PF10635; DisA-linker; 1; |
| PF02457; DisA_N; 1; | |
| PF00633; HHH; 1; |
Features
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| From: DISA_THEMA (Q9WY43) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 107 | 111 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | x-R-x-x-[TS] | ||||||||
| BINDING | 76 | 76 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | G | ||||||||
| BINDING | 94 | 94 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | [LV] | ||||||||
Additional information
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| Size range | 344-374 amino acids |
| Related rules | MF_00838 (DACB); MF_00840 (DACZ); MF_01499 (DACA) |
| Fusion | None |