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Annotation rule MF_01438 |
General rule information
[?]
Accession |
MF_01438 |
Dates |
7-JUN-2006 (Created) 19-NOV-2019 (Last updated, Version 17) |
Scope |
Bacteria; Actinobacteria
Bacteria; Bacillaceae
Bacteria; Clostridia
Bacteria; Fusobacterium
Bacteria; Thermotoga |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Protein name |
RecName:
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Full=DNA integrity scanning protein DisA;
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AltName:
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Full=Diadenylate cyclase;
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EC 2.7.7.85;
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AltName:
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Full=Cyclic di-AMP synthase;
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Short=c-di-AMP synthase;
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case <OC:Bacillaceae> or <OC:Clostridia> or <OC:Frankia> or <OC:Streptomyces>
Function |
Participates in a DNA-damage check-point that is active prior to asymmetric division when DNA is damaged. DisA forms globular foci that rapidly scan along the chromosomes during sporulation, searching for lesions. When a lesion is present, DisA pauses at the lesion site. This triggers a cellular response that culminates in a temporary block in sporulation initiation. |
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Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis. |
else
Function |
Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions. |
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Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process. |
end case
Catalytic activity |
RHEA:35655: 2 ATP = 3',3'-c-di-AMP + 2 diphosphate
EC 2.7.7.85
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Cofactor |
Mg(2+) |
Subunit |
Homooctamer. |
Similarity |
Belongs to the DisA family. |
GO:0003677; Molecular function: DNA binding.
GO:0005524; Molecular function: ATP binding.
GO:0016779; Molecular function: nucleotidyltransferase activity.
GO:0006281; Biological process: DNA repair.
GO:0019932; Biological process: second-messenger-mediated signaling.
From: DISA_THEMA (Q9WY43) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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NP_BIND
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107
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111
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ATP
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x-R-x-x-[TS]
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BINDING
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76
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76
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ATP; via amide nitrogen
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G
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BINDING
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94
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94
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ATP; via amide nitrogen and carbonyl oxygen
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[LV]
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Additional information
[?]