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Annotation rule MF_01451
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General rule information [?]

Accession MF_01451
Dates 4-JUN-2009 (Created)
19-NOV-2019 (Last updated, Version 13)
Name AddA
Scope
Bacteria; Firmicutes
Templates P23478 (ADDA_BACSU); A2RH77 (ADDA_LACLM); Q97QP9 (ADDA_STRPN): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
ADDA
Protein name
RecName: Full=ATP-dependent helicase/nuclease subunit A;
EC 3.1.-.-;
EC 3.6.4.12;
AltName: Full=ATP-dependent helicase/nuclease AddA;
Gene name
addA

Comments [?]

Function The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -> 5' nuclease activities.
Catalytic activity RHEA:13065: ATP + H2O = ADP + H(+) + phosphate
EC 3.6.4.12
Cofactor Mg(2+)
Subunit Heterodimer of AddA and AddB/RexB.
Similarity Belongs to the helicase family. AddA subfamily.

Keywords [?]


Gene Ontology [?]

GO:0003678; Molecular function: DNA helicase activity.
GO:0005524; Molecular function: ATP binding.
GO:0008408; Molecular function: 3'-5' exonuclease activity.
GO:0003690; Molecular function: double-stranded DNA binding.
GO:0000724; Biological process: double-strand break repair via homologous recombination.

Cross-references [?]

PROSITE PS51198; UVRD_HELICASE_ATP_BIND; 1; trigger=PRU00560;
PS51217; UVRD_HELICASE_CTER; 1; trigger=PRU00617;
Pfam PF00580; UvrD-helicase; 1;
TIGRFAMs TIGR02785; AddA_Gpos; 1;

Additional information [?]

Size range 1167-1405 amino acids
Related rules None
Fusion None
Comments Originally called rexA in Lactobacillus and Streptococcus. Forms a heterodimer with 1 of 2 related proteins; in Bacillus and Staphylococcus the partner is addB, in Lactobacillus and Streptococcus the partner is rexB.