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| Annotation rule MF_01451 |
General rule information
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| Accession | MF_01451 |
| Dates | 4-JUN-2009 (Created) 19-NOV-2019 (Last updated, Version 13) |
| Name | AddA |
| Scope | Bacteria; Firmicutes |
| Templates | P23478 (ADDA_BACSU); A2RH77 (ADDA_LACLM); Q97QP9 (ADDA_STRPN): [Recover all] |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -> 5' nuclease activities. |
| Catalytic activity | RHEA:13065: ATP + H2O = ADP + H(+) + phosphate
EC 3.6.4.12 |
| Cofactor | Mg(2+) |
| Subunit | Heterodimer of AddA and AddB/RexB. |
| Similarity | Belongs to the helicase family. AddA subfamily. |
Keywords
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ATP-binding
DNA damage
DNA repair
DNA-binding
Exonuclease
Helicase
Hydrolase
Nuclease
Nucleotide-binding
DNA damage
DNA repair
DNA-binding
Exonuclease
Helicase
Hydrolase
Nuclease
Nucleotide-binding
Gene Ontology
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GO:0003678; Molecular function: DNA helicase activity.
GO:0005524; Molecular function: ATP binding.
GO:0008408; Molecular function: 3'-5' exonuclease activity.
GO:0003690; Molecular function: double-stranded DNA binding.
GO:0000724; Biological process: double-strand break repair via homologous recombination.
GO:0005524; Molecular function: ATP binding.
GO:0008408; Molecular function: 3'-5' exonuclease activity.
GO:0003690; Molecular function: double-stranded DNA binding.
GO:0000724; Biological process: double-strand break repair via homologous recombination.
Cross-references
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| PROSITE | PS51198; UVRD_HELICASE_ATP_BIND; 1; trigger=PRU00560; |
| PS51217; UVRD_HELICASE_CTER; 1; trigger=PRU00617; | |
| Pfam | PF00580; UvrD-helicase; 1; |
| TIGRFAMs | TIGR02785; AddA_Gpos; 1; |
Additional information
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| Size range | 1167-1405 amino acids |
| Related rules | None |
| Fusion | None |
| Comments | Originally called rexA in Lactobacillus and Streptococcus. Forms a heterodimer with 1 of 2 related proteins; in Bacillus and Staphylococcus the partner is addB, in Lactobacillus and Streptococcus the partner is rexB. |