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Annotation rule MF_01456
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General rule information [?]

Accession MF_01456
Dates 12-NOV-2009 (Created)
19-NOV-2019 (Last updated, Version 20)
Name NDH1_NuoK
Scope
Bacteria
Plastid
Templates P0AFE4 (NUOK_ECOLI); Q56226 (NQO11_THET8); P29923 (NQO11_PARDE): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

case <OG:Chloroplast>
Identifier
NU4LC
Protein name
RecName: Full=NAD(P)H-quinone oxidoreductase subunit 4L, chloroplastic;
EC 7.1.1.-;
AltName: Full=NAD(P)H dehydrogenase subunit 4L;
AltName: Full=NADH-plastoquinone oxidoreductase subunit 4L;
Gene name
ndhE
else case <OC:Cyanobacteria>
Identifier
NU4LC
Protein name
RecName: Full=NAD(P)H-quinone oxidoreductase subunit 4L;
EC 7.1.1.-;
AltName: Full=NAD(P)H dehydrogenase subunit 4L;
AltName: Full=NADH-plastoquinone oxidoreductase subunit 4L;
AltName: Full=NDH-1, subunit 4L;
AltName: Full=NDH-E;
Gene name
ndhE
else
Identifier
NUOK
Protein name
RecName: Full=NADH-quinone oxidoreductase subunit K;
EC 7.1.1.-;
AltName: Full=NADH dehydrogenase I subunit K;
AltName: Full=NDH-1 subunit K;
Gene name
nuoK
end case

Comments [?]

case <OG:Chloroplast>
Function NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
else case <OC:Cyanobacteria>
Function NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.
else case <OC:Actinobacteria> or <OC:Bacteroidetes> or <OC:Chlorobi> or <OC:Deinococcus-Thermus> or <OC:Firmicutes>
Function NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
else
Function NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
end case
case <OG:Chloroplast> or <OC:Cyanobacteria>
Catalytic activity RHEA:42608: a plastoquinone + (n+1) H(+)(in) + NADH = a plastoquinol + n H(+)(out) + NAD(+)
RHEA:42612: a plastoquinone + (n+1) H(+)(in) + NADPH = a plastoquinol + n H(+)(out) + NADP(+)
else
Catalytic activity RHEA:57888: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
end case
case <OG:Chloroplast>
Subunit NDH is composed of at least 16 different subunits, 5 of which are encoded in the nucleus.
else case <OC:Cyanobacteria>
Subunit NDH-1 can be composed of about 15 different subunits; different subcomplexes with different compositions have been identified which probably have different functions.
else case <OC:Enterobacterales> or <OC:Shewanellaceae> or <OC:Pseudomonadaceae>
Subunit NDH-1 is composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
else case <OC:Deinococci>
Subunit NDH-1 is composed of 15 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
else
Subunit NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
end case
case <OG:Chloroplast>
Subcellular location Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
else case <OC:Cyanobacteria> and not <OC:Gloeobacter>
Subcellular location Cellular thylakoid membrane; Multi-pass membrane protein.
else case <OC:Gloeobacter>
Subcellular location Cell inner membrane; Multi-pass membrane protein.
else case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location Cell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
Subcellular location Cell inner membrane; Multi-pass membrane protein.
end case
Similarity Belongs to the complex I subunit 4L family.

Keywords [?]

NAD
case <OG:Chloroplast> or <OC:Cyanobacteria>
else case not <OC:Actinobacteria> and not <OC:Bacteroidetes> and not <OC:Chlorobi> and not <OC:Deinococcus-Thermus> and not <OC:Firmicutes>
end case
case <OG:Chloroplast> or <OC:Cyanobacteria> and not <OC:Gloeobacter>
else case <OC:Gloeobacter>
else case not defined <Property:Membrane> or <Property:Membrane=1>
else case <Property:Membrane=2>
end case

Gene Ontology [?]

GO:0055114; Biological process: oxidation-reduction process.
case <OG:Chloroplast> or <OC:Cyanobacteria>
GO:0016655; Molecular function: oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor.
GO:0019684; Biological process: photosynthesis, light reaction.
else
GO:0050136; Molecular function: NADH dehydrogenase (quinone) activity.
end case
case <OC:Cyanobacteria> and not <OC:Gloeobacter>
GO:0042651; Cellular component: thylakoid membrane.
else case <OG:Chloroplast>
GO:0009535; Cellular component: chloroplast thylakoid membrane.
else
GO:0005886; Cellular component: plasma membrane.
end case

Cross-references [?]

Pfam PF00420; Oxidored_q2; 1;

Computed features [?]

General Transmembrane; -; 3; trigger=yes;

Additional information [?]

Size range 93-148 amino acids
Related rules None
Fusion None
Comments 14 proteins form the NDH-1 complex in most bacteria, there are at least 15 subunits in cyanobacteria and chloroplasts. PARDE and THET8 are annotated with another nomenclature.