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Annotation rule MF_01458 |
General rule information
[?]
Accession |
MF_01458 |
Dates |
13-SEP-2010 (Created) 19-NOV-2019 (Last updated, Version 8) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Protein name |
RecName:
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Full=ATP-dependent zinc metalloprotease FtsH;
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EC 3.4.24.-;
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case <OG:Chloroplast>
Function |
Acts as a processive, ATP-dependent zinc metallopeptidase. |
else
Function |
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins. |
end case
case <FTGroup:1>
Cofactor |
Zn(2+) Note: Binds 1 zinc ion per subunit. |
end case
case <OG:Chloroplast>
Subcellular location |
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein; Stromal side. |
else case <OC:Cyanobacteria> and not <OC:Gloeobacter>
Subcellular location |
Cellular thylakoid membrane; Multi-pass membrane protein; Stromal side. |
else case (defined <Property:Membrane> and <Property:Membrane=2>) or <OC:Gloeobacter>
Subcellular location |
Cell inner membrane; Multi-pass membrane protein; Cytoplasmic side. |
else case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location |
Cell membrane; Multi-pass membrane protein; Cytoplasmic side. |
end case
Similarity |
In the central section; belongs to the AAA ATPase family. |
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In the C-terminal section; belongs to the peptidase M41 family. |
case <OG:Chloroplast> or <OC:Cyanobacteria> and not <OC:Gloeobacter>
else case (defined <Property:Membrane> and <Property:Membrane=2>) or <OC:Gloeobacter>
else case not defined <Property:Membrane> or <Property:Membrane=1>
end case
GO:0005524; Molecular function: ATP binding.
GO:0016887; Molecular function: ATPase activity.
GO:0008233; Molecular function: peptidase activity.
GO:0030163; Biological process: protein catabolic process.
case <FTGroup:1>
end case
case <OG:Chloroplast>
GO:0009535; Cellular component: chloroplast thylakoid membrane.
else case <OC:Cyanobacteria> and not <OC:Gloeobacter>
GO:0042651; Cellular component: thylakoid membrane.
else
end case
General |
Transmembrane; -; 2; trigger=yes; |
case <OC:Cyanobacteria> and not <OC:Gloeobacter>
ADD_TOPO_DOMAIN |
Cytoplasmic; -; 2; trigger=yes; |
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Lumenal; -; 1; trigger=yes; |
else case <OG:Chloroplast>
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Stromal; -; 2; trigger=yes; |
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Lumenal; -; 1; trigger=yes; |
else case (defined <Property:Membrane> and <Property:Membrane=2>) or <OC:Gloeobacter>
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Cytoplasmic; -; 2; trigger=yes; |
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Periplasmic; -; 1; trigger=yes; |
else case not defined <Property:Membrane> or <Property:Membrane=1>
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Cytoplasmic; -; 2; trigger=yes; |
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Extracellular; -; 1; trigger=yes; |
end case
From: FTSH_AQUAE (O67077) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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NP_BIND
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195
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202
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ATP
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G-x-[PT]-G-[TVS]-G-K-T
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ACT_SITE
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419
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419
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E
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METAL
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418
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418
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Zinc; catalytic
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H
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1
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METAL
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422
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422
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Zinc; catalytic
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H
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1
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METAL
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496
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496
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Zinc; catalytic
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D
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1
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Additional information
[?]
Size range |
510-854 amino acids |
Related rules |
None |
Fusion |
Nter: <Unknown>; Cter: None |
Comments |
Chlamydiae have an N-terminal extension not found in other organisms. Not all proteins have 2 transmembrane domains. There are short paralogs in Haemophilus that are missing the N-terminal transmembrane section, they are annotated as atypical. Some plastids encode very long homologs that cannot bind zinc, they are annotated as atypical (CHLVU, HELSJ, OLTVI). |