HAMAP rule MF_01463
General rule information
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Accession | MF_01463 |
Dates | 5-JUL-2011 (Created) 1-JUN-2023 (Last updated, Version 10) |
Name | SecD |
Scope | Bacteria
Archaea |
Templates | P0AG90 (SECD_ECOLI); Q5SKE6 (SECDF_THET8); E9RGS3 (SECD_VIBAL); D4GTK5 (SECD_HALVD); O32047 (SECDF_BACSU): [Recover all] |
case <OC:Bacteria>
Triggered by |
end case
case <OC:Archaea>
Triggered by |
end case
Propagated annotation
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Identifier, protein and gene names
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Identifier |
|
case <OC:Bacteria>
Protein name |
|
else case <OC:Archaea>
Protein name |
|
end case
Gene name |
|
Comments
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case <OC:Bacteria>
Function | Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. |
else case <OC:Archaea>
Function | Involved in protein export. |
end case
case <OC:Cyanobacteriota> and not <OC:Gloeobacter>
Function | Probably participates in protein translocation into and across both the cytoplasmic and thylakoid membranes in cyanobacterial cells. |
end case
case <OC:Pseudomonadota>
Subunit | Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC. |
else case <OC:Bacteria>
Subunit | Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved. |
else case <OC:Archaea>
Subunit | Part of the protein translocation apparatus. Forms a complex with SecF. |
end case
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location | Cell membrane; Multi-pass membrane protein. |
else case <Property:Membrane=2>
Subcellular location | Cell inner membrane; Multi-pass membrane protein. |
end case
Similarity | Belongs to the SecD/SecF family. SecD subfamily. |
Keywords
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case defined <Property:Membrane> and <Property:Membrane=2>
end case
Gene Ontology
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GO:0065002; Biological process: intracellular protein transmembrane transport.
GO:0006605; Biological process: protein targeting.
GO:0006605; Biological process: protein targeting.
case <OC:Bacteria>
GO:0043952; Biological process: protein transport by the Sec complex.
end case
GO:0005886; Cellular component: plasma membrane.
Cross-references
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Pfam | PF07549; Sec_GG; 1; |
PF02355; SecD_SecF; 1; | |
PRINTS | PR01755; SECFTRNLCASE; 1; |
NCBIfam | TIGR00916; 2A0604s01; 1; |
TIGR01129; SecD; 1; |
Computed features
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General | Transmembrane; -; 6; trigger=yes; |
Additional information
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case <OC:Bacteria>
Size range | 380-695 amino acids |
end case
case <OC:Archaea>
Size range | 385-570 amino acids |
end case
Related rules | MF_01464 (SECF) |
Fusion | Nter: None; Cter: MF_01464 (SecF) |
Comments | Often found as a SecDF fusion protein. In bacteria the operon consists of secDF. Some archaea have a secFD operon, in others the genes are separated on the genome. |