HAMAP rule MF_01463
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_01463 |
| Accession | MF_01463 |
| Dates | 5-JUL-2011 (Created)
1-JUN-2023 (Last updated, Version 10) |
| Name | SecD |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P0AG90 (SECD_ECOLI); Q5SKE6 (SECDF_THET8); E9RGS3 (SECD_VIBAL); D4GTK5 (SECD_HALVD); O32047 (SECDF_BACSU); [ Recover all ] |
| Triggered by |
case c? <OC:Bacteria>
HAMAP; MF_01463_B (Get profile general information and statistics) end case
case c? <OC:Archaea>
HAMAP; MF_01463_A (Get profile general information and statistics) end case
|
Propagated annotation
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Identifier, protein and gene names
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| Identifier | SECD |
| case <OC:Bacteria> | |
| Protein name | RecName: Full=Protein translocase subunit SecD; |
| else case <OC:Archaea> | |
| Protein name | RecName: Full=Protein-export membrane protein SecD; |
| end case | |
| Gene name | Name=secD; |
Comments
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| case <OC:Bacteria> | |
| FUNCTION | Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. |
| else case <OC:Archaea> | |
| FUNCTION | Involved in protein export. |
| end case | |
| case <OC:Cyanobacteriota> and not <OC:Gloeobacter> | |
| FUNCTION | Probably participates in protein translocation into and across both the cytoplasmic and thylakoid membranes in cyanobacterial cells. |
| end case | |
| case <OC:Pseudomonadota> | |
| SUBUNIT | Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC. |
| else case <OC:Bacteria> | |
| SUBUNIT | Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved. |
| else case <OC:Archaea> | |
| SUBUNIT | Part of the protein translocation apparatus. Forms a complex with SecF. |
| end case | |
| case not defined <Property:Membrane> or <Property:Membrane=1> | |
| SUBCELLULAR LOCATION | Cell membrane; Multi-pass membrane protein. |
| else case <Property:Membrane=2> | |
| SUBCELLULAR LOCATION | Cell inner membrane; Multi-pass membrane protein. |
| end case | |
| SIMILARITY | Belongs to the SecD/SecF family. SecD subfamily. |
Keywords
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| case defined <Property:Membrane> and <Property:Membrane=2> | |
| Cell inner membrane | |
| end case | |
| Cell membrane | |
| Membrane | |
| Protein transport | |
| Translocation | |
| Transmembrane | |
| Transmembrane helix | |
| Transport | |
Gene Ontology
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| GO:0065002; Biological process:intracellular protein transmembrane transport | |
| GO:0006605; Biological process:protein targeting | |
| case <OCellular component:Bacteria> | |
| GO:0043952; Biological process:protein transport by the Sec complex | |
| end case | |
| GO:0005886; Cellular component:plasma membrane | |
Cross-references
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| Pfam | PF07549; Sec_GG; 1; |
| Pfam | PF02355; SecD_SecF; 1; |
| PRINTS | PR01755; SECFTRNLCASE; 1; |
| NCBIfam | TIGR00916; 2A0604s01; 1; |
| NCBIfam | TIGR01129; SecD; 1; |
| General | Transmembrane; -; 6; |
Features
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Additional information
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| Size range | 385-570 amino acids |
| Related rules |
MF_01464 |
| Fusion | Nter: None Cter: MF_01464 (SecF) |
| Comments | Often found as a SecDF fusion protein. In bacteria the operon consists of secDF. Some archaea have a secFD operon, in others the genes are separated on the genome. |